Patents by Inventor Volker Autze
Volker Autze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8013117Abstract: A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.Type: GrantFiled: November 21, 2006Date of Patent: September 6, 2011Assignee: Nanokem S.A.Inventors: Daniel Kadzimirsz, Gerhard Jas, Volker Autze
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Publication number: 20090005535Abstract: The invention relates to a process for producing the nonapeptide leuprolide and the intermediate N-protected oligopetides thereof, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.Type: ApplicationFiled: November 21, 2006Publication date: January 1, 2009Applicant: NANOKEM S.A.Inventors: Daniel Kadzimirzs, Gerhard Jas, Volker Autze
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Patent number: 7468165Abstract: The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.Type: GrantFiled: October 21, 2002Date of Patent: December 23, 2008Inventors: Sebastian Oberbeck, Volker Autze, Klaus Golbig
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Patent number: 7435392Abstract: A parallel chemical production system producing a desired product by operating a plurality of reactors in parallel. The fluidic properties of each of the reactors are identical to the properties of a test reactor employed to determine conditions for producing the product, to facilitate scaling up production. In one embodiment, the production system is configured such that at least one reactor is always offline for cleaning, servicing, and use as a backup. If sensors detect less than optimal conditions in any reactor, the reactor is taken offline and serviced, while a previously designated backup reactor is placed online to maintain continuous production. Another aspect involves arranging the reactors in a concentric configuration to facilitate equal fluid distribution.Type: GrantFiled: June 6, 2003Date of Patent: October 14, 2008Assignee: Acclavis, LLCInventors: Sebastian Oberbeck, Thomas Schwalbe, Volker Autze, Klaus Poelderl
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Patent number: 7241423Abstract: A stacked plate chemical reactor in which simple plates are stacked together to form the reactor. When openings in adjacent plates are properly aligned, fluid pathways and processing volumes are defined for chemical reactants, heat transfer medium, and a product. In one embodiment of the invention, an n-fold internal array is achieved by providing a first group of simple plates defining a reaction unit that includes bypass fluid channels and reaction fluid channels for each reactant, such that a portion of each reactant is directed to subsequent groups of simple plates defining additional reaction units. A chemical reactor with variable output is obtained in a preferred embodiment by reversibly joining reactor stacks comprising irreversibly joined reaction units, these reaction units consisting of a plurality of simple plates.Type: GrantFiled: November 15, 2001Date of Patent: July 10, 2007Assignee: Cellular Process Chemistry, Inc.Inventors: Klaus Golbig, Volker Autze, Peter Born, Christian Drescher
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Publication number: 20060234381Abstract: A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.Type: ApplicationFiled: June 22, 2006Publication date: October 19, 2006Applicant: Cellular Process Chemistry, Inc.Inventors: Thomas Schwalbe, Volker Autze, Sebastian Oberbeck, Ansgar Kursawe, Kemal Sahin
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Patent number: 7101515Abstract: A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.Type: GrantFiled: April 14, 2004Date of Patent: September 5, 2006Assignee: Cellular Process Chemistry, Inc.Inventors: Thomas Jochen Schwalbe, Volker Autze, Sebastian Oberbeck, Ansgar Kursawe, Kemal Hünkar Sahin
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Publication number: 20050025677Abstract: The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.Type: ApplicationFiled: October 21, 2002Publication date: February 3, 2005Inventors: Sebastian Oberbeck, Volker Autze, Klaus Golbig
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Publication number: 20050013738Abstract: A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.Type: ApplicationFiled: April 14, 2004Publication date: January 20, 2005Applicant: Cellular Process Chemistry, Inc.Inventors: Thomas Schwalbe, Volker Autze, Sebastian Oberbeck, Ansgar Kursawe, Kemal Sahin
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Publication number: 20030223909Abstract: A parallel chemical production system producing a desired product by operating a plurality of reactors in parallel. The fluidic properties of each of the reactors are identical to the properties of a test reactor employed to determine conditions for producing the product, to facilitate scaling up production. In one embodiment, the production system is configured such that at least one reactor is always offline for cleaning, servicing, and use as a backup. If sensors detect less than optimal conditions in any reactor, the reactor is taken offline and serviced, while a previously designated backup reactor is placed online to maintain continuous production. Another aspect involves arranging the reactors in a concentric configuration to facilitate equal fluid distribution.Type: ApplicationFiled: June 6, 2003Publication date: December 4, 2003Applicant: Cellular Process Chemistry, Inc.Inventors: Sebastian Oberbeck, Thomas Schwalbe, Volker Autze, Klaus Poelderl
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Publication number: 20020106311Abstract: A stacked plate chemical reactor in which simple plates are stacked together to form the reactor. When openings in adjacent plates are properly aligned, fluid pathways and processing volumes are defined for chemical reactants, heat transfer medium, and a product. In one embodiment of the invention, an n-fold internal array is achieved by providing a first group of simple plates defining a reaction unit that includes bypass fluid channels and reaction fluid channels for each reactant, such that a portion of each reactant is directed to subsequent groups of simple plates defining additional reaction units. A chemical reactor with variable output is obtained in a preferred embodiment by reversibly joining reactor stacks comprising irreversibly joined reaction units, these reaction units consisting of a plurality of simple plates.Type: ApplicationFiled: November 15, 2001Publication date: August 8, 2002Applicant: Cellular Process Chemistry, Inc.Inventors: Klaus Golbig, Volker Autze, Peter Born, Christian Drescher