Patents by Inventor Volker-Bernd Fiedler
Volker-Bernd Fiedler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5565561Abstract: The invention relates to the natural substance cyclamenol of the formula ##STR1## a process for its preparation from microorganisms of the order of the Actinomycetales, in particular from the Streptomyces strain MHW 846, chemical derivatives thereof, and its use as a medicament, in particular for acute and chronic inflammatory disorders in human and veterinary medicine.Type: GrantFiled: April 27, 1995Date of Patent: October 15, 1996Assignee: Bayer AktiengesellschaftInventors: Hartwig M uller, Erwin Bischoff, Volker-Bernd Fiedler, Karlheinz Weber, Burkhard Fugmann, Bruno Rosen
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Patent number: 5374647Abstract: Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.Type: GrantFiled: April 5, 1993Date of Patent: December 20, 1994Assignee: Bayer AktiengesellschaftInventors: Horst Bohagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
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Patent number: 5264458Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.Type: GrantFiled: July 14, 1992Date of Patent: November 23, 1993Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Elisabeth Perzborn, Volker-Bernd Fiedler, Peter Norman, Hilary P. Francis, Marie G. McKenniff
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Patent number: 5191092Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.Type: GrantFiled: September 26, 1990Date of Patent: March 2, 1993Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Elisabeth Perzborn, Volker-Bernd Fiedler, Peter Norma, Hilary P. Francis, Marie G. McKenniff
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Patent number: 5096897Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1, 2, 3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.Type: GrantFiled: March 28, 1991Date of Patent: March 17, 1992Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
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Patent number: 5079258Abstract: Tetrahydro-1-benz-[c,d],indolepropionic acid sulphonamides of the formula ##STR1## can be prepared by reaction of tetrahydro-1-benz-[c,d]-indolesulphonamides with acrylonitrile and subsequent hydrolysis. The new compounds can be employed inhibiting thrombocyte aggregation.Type: GrantFiled: July 24, 1989Date of Patent: January 7, 1992Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 5039670Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.Type: GrantFiled: October 17, 1990Date of Patent: August 13, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
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Patent number: 5015657Abstract: Inhibiting platelet aggregation and antagonizing thromboxane A.sub.2 with new 2-halogen-substituted N-indolyethyl-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl having up to 8 carbon atoms, orrepresents straight-chain or branched alkyl having up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, which is optionally substituted by carboxyl, halogen, alkoxy or alkoxycarbonyl having in each case up to 8 carbon atoms, cyano or hydroxyl, orrepresents a group of the formula --S(O).sub.n --R.sup.5,--NR.sup.6 R.sup.7 or --OR.sup.Type: GrantFiled: November 15, 1989Date of Patent: May 14, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4988820Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O).sub.m R.sup.3, in which R.sup.3 denotes alkyl or aryl, and m denotes one of the numbers 0, 1 or 2, represents a group of the formula ##STR2## in which R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, aryl, aralkyl or acetyl, represents a group of the formula --OR.sup.6, in which R.sup.6 denotes hydrogen, alkyl, aryl, aralkyl, alkyl-SO.sub.2 --, aryl--SO.sub.2 --, aralkyl--SO.sub.2 -- or trifluoromethyl, or represents alkyl, alkenyl or cycloalkyl, each of which is optionally substituted by carboxyl, alkoxycarbonyl, halogen, hydroxyl, alkoxy, alkylthio or cyano, R.sup.Type: GrantFiled: July 20, 1990Date of Patent: January 29, 1991Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4965258Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2.Type: GrantFiled: November 28, 1989Date of Patent: October 23, 1990Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4921998Abstract: Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substrituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, andR.sup.5 and R.sup.6 each independently is hydrogen or alkyl, orone of the radicals R.sup.5 or R.sup.6 is benzyl, and physiologically acceptable salts thereof with mono- and divalent cations.Type: GrantFiled: May 15, 1989Date of Patent: May 1, 1990Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Bodo Junge, Elisabeth Perzborn, Friedel Seuter, Volker-Bernd Fiedler
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Patent number: 4904797Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.Type: GrantFiled: February 8, 1989Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4886898Abstract: Certain intermediate aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivatives of the formula ##STR1## in which R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,which are useful in preparing the corresponding aryl-sulfonamides which in-turn have antithrombotic, antiatherosclerotic and antiischaemic properties.Type: GrantFiled: May 16, 1989Date of Patent: December 12, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4882353Abstract: For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,R.sup.2 and R.sup.3 are identical or different and stand for hydrogen, alkyl, cycloalkyl or aryl,R.sup.4 stands for hydroxyl, alkoxy, aryloxy, aralkoxy or for a group of the formula --NR.sup.5 R.sup.6, whereR.sup.5 and R.sup.6 are identical or different and in each case denote hydrogen, alkyl, aryl or aralkyl,X denotes a direct bond or an oxygen or sulphur atom, NH or N-alkyl, andn denotes 0 or 1,and their physiologically tolerable salts.Type: GrantFiled: October 26, 1988Date of Patent: November 21, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Hermann Oediger, Ulrich Rosentreter, Horst Boshagen, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4868332Abstract: An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,and physiologically acceptable salts thereof with monovalent or divalent cations which have antithrombotic, antiatherosclerotic and antiischaemic activities.Type: GrantFiled: November 23, 1987Date of Patent: September 19, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4868331Abstract: Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, andR.sup.5 and R.sup.6 each independently is hydrogen or alkyl, orone of the radicals R.sup.5 or R.sup.6 is benzyl,and physiologically acceptable salts thereof with mono- and divalent cations.Type: GrantFiled: June 29, 1987Date of Patent: September 19, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Bodo Junge, Elisabeth Perzborn, Friedel Seuter, Volker-Bernd Fiedler
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Patent number: 4853406Abstract: Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aryl, aralkyl or acyl andX is cyano or carboxyl, and salts thereof. Intermediates therefor of the formula ##STR3## are also new.Type: GrantFiled: May 31, 1988Date of Patent: August 1, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Ulrich Niewohner, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4843091Abstract: An N-sulphonamidoethyl-indole of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, aryl, arylthio, aralkyl, aralkoxy, aralkylthio, acyl or a group of the formula ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl, andR.sup.3 represents hydrogen, alkyl, aryl, pyridyl, thienyl or furyl, andR.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, aryl, aryloxy, arylthio, aralkyl, aralkoxy, aralkylthio, acl or a group of the formula ##STR3## in which R.sup.7 and R.sup.8 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl,R.sup.5 represents hydrogen, ##STR4## or a pharmacologically acceptable salt of ##STR5## and R.sup.2 represents hydrogen, alkyl or aryl.The compounds were R.sup.Type: GrantFiled: June 5, 1987Date of Patent: June 27, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter
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Patent number: 4827032Abstract: Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.Type: GrantFiled: June 29, 1988Date of Patent: May 2, 1989Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
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Patent number: 4806551Abstract: New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These compounds exhibit a platelet aggregation-inhibiting and thromboxan A.sub.2 -antagonistic action.The N-dihydroindolylethyl-sulphonamides have the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, or represents a group of the formula --S(O).sub.m R.sup.5,whereinR.sup.5 denotes alkyl or aryl andm denotes one of the numbers 0, 1 or 2, orR.sup.1 represents a group of the formula ##STR2## or R.sup.1 represents a group of the formula --OR.sup.8, orR.sup.1 represents optionally substituted alkyl, alkenyl or cycloalkyl,R.sup.2 represents aryl, which is optionally substituted by up to 5 substituents,R.sup.3 represents hydrogenor alkyl andR.sup.4 represents hydrogen, orR.sup.3 and R.sup.4 together bond a carbonyl oxygen.Type: GrantFiled: April 16, 1987Date of Patent: February 21, 1989Assignee: Bayer AktiengesellschaftInventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter