Abstract: The present invention relates to a method for providing bacterial or yeast cells with the capacity to produce a protein, the amino acid sequence of which comprises at least one unconventional amino acid. The method involves (a) introducing at least one missense mutation in a target codon of a gene encoding a protein required for the growth of the bacterial or yeast cells, where the mutated protein synthesized from the mutated gene is not functional in the bacterial or yeast cells. The method also involves (b) selecting the bacterial or yeast cells obtained in (a) in a culture medium which (1) does not contain a nutrient compensating for the loss of functionality of the mutated protein and (2) contains an unconventional amino acid which restores the functionality of the protein required for growth of the bacterial or yeast cells, in which the unconventional amino acid is that encoded by the target codon.

Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.

Abstract: This invention relates to a process for preparing 2?-deoxynucleoside compounds or 2?-deoxynucleoside precursors using 2-dehydro-3-deoxy-D-gluconic acid (usually abbreviated as KDG) or its salts as a starting material. A variety of 2?-deoxynucleosides and their analogues are used as a starting material for synthesis or drug formulation in production of an antiviral, anticancer or antisense agent.

Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.

Abstract: In an exhaust gas turbine for a turbocharger of an internal combustion engine, including a housing with an inlet passage for conducting exhaust gas onto a turbine wheel supported in the housing, a guide vane structure movable into, and out of, an annular space of the inlet passage around the turbine wheel, an operating mechanism for moving the guide vane structure is provided which includes a cylinder, a ring provided with axial passages disposed around an inner sleeve, the guide vane structure being connected to one end of claws movably disposed in the axial passages and at least one of the claws being connected at its other end to the operating mechanism.

Abstract: The invention concerns a method for producing a cyclic L-amino acid of formula (I), characterised in that it consists in reacting a L-diamino acid of formula (II) or an enantiomeric mixture comprising such a L-diamino acid and a corresponding D-diamino acid in variable proportions, in the presence of an ornithine cyclodeaminase or a polypeptide homologous to the ornithine cyclodeaminase.

Abstract: In an exhaust gas turbine for a turbocharger of an internal combustion engine with a casing and a rotor rotatably supported in the casing, the casing includes an inlet duct with a guide vane structure supported so as to be movable into and out of a flow inlet area to the rotor by means of an electric motor.

Abstract: The invention concerns mutant prokaryotic cells, in particular E. coli, capable of producing proteins whereof the amino acid sequences comprise at least a non-conventional amino acid, methods for producing and purifying said proteins and the proteins obtained by said methods. The invention also concerns uses of said cells and proteins in different fields such as in therapy, cosmetics, diagnosis or biosynthesis or biodegradation of organic compounds.

Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.

Abstract: An exhaust-gas turbine for a turbocharger includes a rotor mounted rotatably in a turbine casing having a spiral inlet duct which is followed by an annular space surrounding the rotor. A guide-blade cascade is capable of being pushed axially into the annular space near the outer circumference of the rotor. The guide-blade cascade includes guide blades, is guided in an annular gap between an inner part and the turbine casing and is axially displaceable via an axial slide by a sliding sleeve.

Abstract: In an exhaust turbine of a turbocharger with a rotor mounted rotatably in a turbine casing having a spiral inlet duct with a guide vane structure including guide vanes arranged around the rotor and extending essentially tangentially to an outer and inner imaginary circular surface areas in the inflow zone and, respectively, the outflow zone of the guide vane structure, at least the trailing edges but preferably also the leading edges of the guide vanes extend at an angle to an axial line of the imaginary circular surface areas, thereby providing for a uniform loading of the rotor.

Abstract: In an exhaust turbine for a turbocharger having a rotor rotatably supported in a turbine casing wherein the turbine casing has a spiral inlet with an annular space disposed directly around the rotor and an axial cavity extending from the annular space axially into the casing and slideably receiving a guide vane structure so as to be movable between a retracted position in the annular space and an extended position, in which the guide vane structure is disposed in the annular space, the guide vane structure has opposite outer and inner cover rings and the turbine casing has a recess opposite the axial cavity so that in the extended position of the guide vane structure its outer cover ring is fittingly received in the recess while the inner cover ring is disposed at the outer end of the axial cavity providing for a smooth inlet flow duct surface.

Abstract: In an exhaust turbine of a turbocharger with a rotor mounted rotatably in a turbine casing having a spiral inlet duct with a guide vane structure including guide vanes arranged around the rotor and extending essentially tangentially to an outer and inner imaginary circular surface areas in the inflow zone and, respectively, the outflow zone of the guide vane structure, at least the trailing edges but preferably also the leading edges of the guide vanes extend at an angle to an axial line of the imaginary circular surface areas, thereby providing for a uniform loading of the rotor.

Abstract: In an accessory unit drive arrangement of an internal combustion engine the accessory unit is mounted on the engine such that its drive shaft is arranged in axial alignment with an engine-operated shaft. The drive shaft is coupled to the engine-operated shaft by a coupling structure which includes a pin which projects axially eccentrically from the end face of the engine-operated shaft and engages a carrier mounted on the drive shaft of the accessory unit. The engine-operated shaft is supported by a friction bearing and a lubricant collecting space is in communication with the friction bearing so as to collect lubricant leaking from the bearing for the lubrication of the coupling structure.

Abstract: The thermotropic aromatic polyesters according to the invention which contain recurring units corresponding to the following formulae ##STR1## show improved resistance to chemicals, low melting points and, hence, good processibility in addition to the well-known favorable mechanical properties of liquid-crystal materials. The thermotropic aromatic polyesters are used for the production of moldings, filaments, fibers and films.

Abstract: Process for depicting the distribution of high activities of radioactive substances by means of a whole-body scintigraphic device having a camera or the like, such as a gamma camera or scanner, characterized in that the radiation incident upon the camera is partially shielded against as a function of its intensity in order to optimize the counting rate, as well as a device for implementing such a process.