Abstract: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3? and 5? ends with an adapter primer; b) the product from step a) is hybridized on the 3? and 5? ends with an extension primer containing an extension sequence, wherein a nucleic acid with extension sequences amplified and enlarged in the 3? and 5? ends of the nucleic acid base sequence is then formed from the nucleic acid base sequence. The invention also relates to different applications of the inventive method.

Abstract: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3? and 5? ends with an adapter primer; b) the product from step a) is hybridized on the 3? and 5? ends with an extension primer containing an extension sequence, wherein a nucleic acid with extension sequences amplified and enlarged in the 3? and 5? ends of the nucleic acid base sequence is then formed from the nucleic acid base sequence. The invention also relates to different applications of the inventive method.

Abstract: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3? and 5? ends with an adapter primer; b) the product from step a) is hybridized on the 3? and 5? ends with an extension primer containing an extension sequence, wherein a nucleic acid with extension sequences amplified and enlarged in the 3? and 5? ends of the nucleic acid base sequence is then formed from the nucleic acid base sequence. The invention also relates to different applications of the inventive method.

Abstract: The invention relates to a nucleic acid library or protein or peptide library in the form of a two-dimensionally resolved grid-type arrangement with a plurality of grid elements. Every grid element contains, on the statistical average, a defined number of nucleic acid types or protein or peptide types having a respective specific sequence structure. The inventive library is further characterized in that the grid elements are configured as capillary hollow spaces. The capillary axes of said capillary hollow spaces are in parallel to one another and the openings of different capillary hollow spaces are arranged in a grid area. The invention further relates to various uses of such a library.

Abstract: The present invention relates to DNA enzymes of type 10-23 with certain modifications of specific nucleotides in the core sequence rendering the DNA enzymes particularly stable and additionally exhibiting substantially the same or a higher cleavage efficiency with respect to their substrate when compared against the corresponding unmodified DNA enzymes. The present application further provides host cells containing the DNA enzymes according to the invention. In addition there is provided a pharmaceutical formulation which contains the DNA enzymes or host cells according to the invention. The DNA enzymes and further subjects are directed in particular against the vanilloid receptor 1 (VR1), or picornaviruses. The present invention further provides small interference RNA molecules (siRNA) directed against VR1, and host cells containing the siRNA.

Abstract: The invention relates to novel streptavidin binding peptides.

Abstract: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3? and 5? ends with an adapter primer; b) the product from step a) is hybridized on the 3? and 5? ends with an extension primer containing an extension sequence, wherein a nucleic acid with extension sequences amplified and enlarged in the 3? and 5? ends of the nucleic acid base sequence is then formed from the nucleic acid base sequence. The invention also relates to different applications of the inventive method.

Abstract: The invention relates to a method for gene expression in a cell-free transcription/translation system, the reaction solution containing all the components necessary for the transcription/translation mechanism, amino acids, nucleotides, metabolic components which provide energy and which are necessary for synthesis, and the proteins arising during translation being immobilized on a matrix.

Abstract: The invention relates to a nucleic acid library or protein or peptide library in the form of a two-dimensionally resolved grid-type arrangement with a plurality of grid elements. Every grid element contains, on the statistical average, a defined number of nucleic acid types or protein or peptide types having a respective specific sequence structure. The inventive library is further characterized in that the grid elements are configured as capillary hollow spaces. The capillary axes of said capillary hollow spaces are in parallel to one another and the openings of different capillary hollow spaces are arranged in a grid area. The invention further relates to various uses of such a library.