Patents by Inventor Volker Jeske

Volker Jeske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPRESSION AND FOLDING IN THE MANUFACTURING PROCESS OF CD-RAP BY USING A CD-RAP PRECURSOR PROTEIN
    Publication number: 20200268663
    Abstract: The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
    Type: Application
    Filed: March 18, 2020
    Publication date: August 27, 2020
    Inventors: Isabell SCHOETTLE, Judith STOMMES, Paul HABERMANN, Bernd JANOCHA, Thomas STILLGER, Eckart BARTNIK, Volker JESKE, Joachim SAAS
  • Expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein
    Patent number: 10660852
    Abstract: The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: May 26, 2020
    Assignee: BIONET PHARMA GMBH
    Inventors: Isabell Schoettle, Judith Stommes, Paul Habermann, Bernd Janocha, Ursula Stillger, Eckart Bartnik, Volker Jeske, Joachim Saas
  • IMPROVEMENT OF EXPRESSION AND FOLDING IN THE MANUFACTURING PROCESS OF CD-RAP BY USING A CD-RAP PRECURSOR PROTEIN
    Publication number: 20190046442
    Abstract: The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 14, 2019
    Inventors: Isabell SCHOETTLE, Judith STOMMES, Paul HABERMANN, Bernd JANOCHA, Ursula STILLGER, Eckart BARTNIK, Volker JESKE, Joachim SAAS
  • METHODS FOR DETERMINING THE ACTIVITY OF ADAM-TS PROTEASES USING THIOPEPTOLIDES
    Publication number: 20090149332
    Abstract: The invention concerns the use of thiopeptolides of formula R-(Xaa)n-Pro-X-Gly-S—Y-Z-Gly-(Xaa)m-R1 (I) as substrate for determining the activity of ADAMTS proteases, and a method for finding an ADAMTS protease modulator, more particularly an inhibitor.
    Type: Application
    Filed: February 10, 2006
    Publication date: June 11, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Klaus-Ulrich Weithmann, Volker Jeske