Patents by Inventor Volker Pfahlert
Volker Pfahlert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11175361Abstract: A method for performing an NMR measurement on a sample contained in a sample tube by using an NMR spectrometer includes: a) feeding a first measuring sample tube in a guiding direction to a pre-measuring area being located, in the guiding direction, before a measuring area of the NMR spectrometer, the pre-measuring area being arranged and designed for measuring a sample parameter of a sample contained in the first measuring sample tube to determine or to estimate an NMR parameter; b) feeding the first measuring sample tube in the guiding direction towards the measuring area; c) setting the NMR parameter previously determined or estimated; and d) carrying out an NMR measurement of the sample contained in the first measuring sample tube on the basis of the set NMR parameter.Type: GrantFiled: March 6, 2017Date of Patent: November 16, 2021Assignee: numares AGInventors: Fritz Huber, Volker Pfahlert, Martin Reinhard Arnold
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Publication number: 20210318337Abstract: An in vitro method for calculating a glomerular filtration rate of an individual or an indicator of a pathophysiologic factor of an impaired glomerular filtration rate is provided. The method may include the following steps: providing a blood sample from an individual; determining the concentration of at least three substances chosen from alanine, choline, creatine, creatinine, dimethyl sulfone, dimethylamine, glucose, glycerol, isoleucine, leucine, myo-inositol, N,N-dimethylglycine, and valine in the blood sample by analyzing the blood sample with a suited measuring technique; and calculating a predicted glomerular filtration rate or an indicator of a pathophysiologic factor of an impaired glomerular filtration rate from the determined concentrations of the substances.Type: ApplicationFiled: September 30, 2019Publication date: October 14, 2021Inventors: Eric SCHIFFER, Jana FRUTH, Volker PFAHLERT, Maximilian ZUCKER, Tobias STEINLE, Johannes EIGLSPERGER
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Publication number: 20200051669Abstract: A method for characterizing a sample is disclosed, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. Furthermore, a method for characterizing a system is disclosed in which method the preceding method is used.Type: ApplicationFiled: October 16, 2019Publication date: February 13, 2020Inventors: Fritz Huber, Renate Kirchhöfer, Volker Pfahlert
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Publication number: 20200003787Abstract: Provided is an in vitro method for determining the risk of kidney rejection of an individual after having obtained a kidney donation using a marker set including at least three substances chosen from the group consisting of 3-hydroxy isovalerate, acetyl carnitine, alanine, citrate, dimethylamine, glucose, glucuronate, hippurate, lactate, malonate, methyl guanidine, methyl malonate, methyl succinate, p-cresol, phenyl acetate, phenylacetylglycine, phenylacetylglutamine, taurine, trigonelline, and urea. The marker set also includes at least one substance chosen from the group consisting of alanine, dimethylamine, glucuronate, phenylacetylglutamine, and urea.Type: ApplicationFiled: March 14, 2018Publication date: January 2, 2020Inventors: Johannes Eiglsperger, Sindy Neumann, Philipp Pagel, Maximilian Zucker, Volker Pfahlert
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Patent number: 10497465Abstract: A method for characterizing a sample is disclosed, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. Furthermore, a method for characterizing a system is disclosed in which method the preceding method is used.Type: GrantFiled: October 5, 2011Date of Patent: December 3, 2019Assignee: numares AGInventors: Fritz Huber, Renate Kirchhoefer, Volker Pfahlert
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Publication number: 20190107592Abstract: A method for performing an NMR measurement on a sample contained in a sample tube by using an NMR spectrometer includes: a) feeding a first measuring sample tube in a guiding direction to a pre-measuring area being located, in the guiding direction, before a measuring area of the NMR spectrometer, the pre-measuring area being arranged and designed for measuring a sample parameter of a sample contained in the first measuring sample tube to determine or to estimate an NMR parameter; b) feeding the first measuring sample tube in the guiding direction towards the measuring area; c) setting the NMR parameter previously determined or estimated; and d) carrying out an NMR measurement of the sample contained in the first measuring sample tube on the basis of the set NMR parameter.Type: ApplicationFiled: March 6, 2017Publication date: April 11, 2019Inventors: Fritz Huber, Volker Pfahlert, Martin Reinhard Arnold
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Patent number: 10114093Abstract: A method for extracting information encoded in a result of an NMR measurement, including the following steps: providing a first result of an NMR measurement of a sample; providing a second result of an NMR measurement of a calibration sample; calculating a conversion factor being indicative for a dependency between encoded information on the calibration sample and the concentration of at least one constituent of the calibration sample, applying the conversion factor to information encoded in the first result, calculating a validity value for a subset of the encoded information of the first result, the validity value being representative for a fitness of a first subset of the encoded information to be separated from a second subset of the encoded information, and assigning the validity value to the subset of the encoded information for which it was calculated.Type: GrantFiled: September 11, 2015Date of Patent: October 30, 2018Assignee: numares AGInventors: Fritz Huber, Volker Pfahlert
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Patent number: 9958467Abstract: Provided is a method for supplementing a sample with specific information. This method includes the following steps: intrinsically marking a sample by adding a chemical marker having a defined composition to the sample; storing data reflecting the composition of the chemical marker and information assigned to the chemical marker, wherein this marker-assigned information is not related to the composition of the chemical marker itself; analyzing the sample with an analysis method, wherein the analysis method is suited to detect the composition of the chemical marker, to obtain a marker-related result; comparing the marker-related result with the stored data; and assigning the marker-assigned stored information to the sample based on the preceding comparison.Type: GrantFiled: December 11, 2013Date of Patent: May 1, 2018Assignee: numares AGInventors: Fritz Huber, Volker Pfahlert, Markus Fuhrmann, Renate Kirchhöfer
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Publication number: 20170261576Abstract: A method for extracting information encoded in a result of an NMR measurement, including the following steps: providing a first result of an NMR measurement of a sample; providing a second result of an NMR measurement of a calibration sample; calculating a conversion factor being indicative for a dependency between encoded information on the calibration sample and the concentration of at least one constituent of the calibration sample, applying the conversion factor to information encoded in the first result, calculating a validity value for a subset of the encoded information of the first result, the validity value being representative for a fitness of a first subset of the encoded information to be separated from a second subset of the encoded information, and assigning the validity value to the subset of the encoded information for which it was calculated.Type: ApplicationFiled: September 11, 2015Publication date: September 14, 2017Inventors: Fritz Huber, Volker Pfahlert
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Patent number: 9285444Abstract: The present invention relates to a method which allows for an automatic substance identification on the basis of an NMR spectrum. In the scope of the method, determining a multitude of integral ratio values, in each case from at least two integral values of the NMR spectrum, takes place, wherein each integral ratio value specifies the ratio of the height and/or area of the underlying spectral values, and determining a multitude of distance values, in each case from at least two position values of the NMR spectrum, takes place, wherein each distance value specifies the spectral distance between the underlying spectral values. The integral ratio values and the distance values are then used for substance identification.Type: GrantFiled: April 4, 2013Date of Patent: March 15, 2016Assignee: numares AGInventors: Fritz Huber, Volker Pfahlert, Renate Kirchhoefer, Andreas Krumpel
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Publication number: 20150331002Abstract: Provided is a method for supplementing a sample with specific information. This method includes the following steps: intrinsically marking a sample by adding a chemical marker having a defined composition to the sample; storing data reflecting the composition of the chemical marker and information assigned to the chemical marker, wherein this marker-assigned information is not related to the composition of the chemical marker itself; analyzing the sample with an analysis method, wherein the analysis method is suited to detect the composition of the chemical marker, to obtain a marker-related result; comparing the marker-related result with the stored data; and assigning the marker-assigned stored information to the sample based on the preceding comparison.Type: ApplicationFiled: December 11, 2013Publication date: November 19, 2015Inventors: Fritz Huber, Volker Pfahlert, Markus Fuhrmann, Renate Kirchhöfer
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Publication number: 20150042328Abstract: The present invention relates to a method which allows for an automatic substance identification on the basis of an NMR spectrum. In the scope of the method, determining a multitude of integral ratio values, in each case from at least two integral values of the NMR spectrum, takes place, wherein each integral ratio value specifies the ratio of the height and/or area of the underlying spectral values, and determining a multitude of distance values, in each case from at least two position values of the NMR spectrum, takes place, wherein each distance value specifies the spectral distance between the underlying spectral values. The integral ratio values and the distance values are then used for substance identification.Type: ApplicationFiled: April 4, 2013Publication date: February 12, 2015Applicant: Numares AGInventors: Fritz Huber, Volker Pfahlert, Renate Kirchhoefer, Andreas Krumpel
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Publication number: 20130289887Abstract: The invention relates to a method for characterizing a sample, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. The invention further relates to a method for characterizing a system in which method the preceding method is used.Type: ApplicationFiled: October 5, 2011Publication date: October 31, 2013Applicant: NUMARES GMBHInventors: Fritz Huber, Renate Kirchhoefer, Volker Pfahlert
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Patent number: 4968683Abstract: New 6-oxo-pyridazine derivatives corresponding to the general formula I ##STR1## which represent new, positive inotropic compounds having a higher and more selective inotropy-increasing activity are described.A process of preparation and the medical use of these substances or of a medicament containing these substances are also described.Type: GrantFiled: April 14, 1989Date of Patent: November 6, 1990Assignee: Heumann Pharma GmbH & Co.Inventors: Peter Morsdorf, Rolf Herter, Heidrun Engler, Volker Pfahlert, Reinhold Weidner, Kurt H. Ahrens
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Patent number: 4957920Abstract: New benzimidazoles corresponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value of 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations containing these compounds.Type: GrantFiled: March 15, 1988Date of Patent: September 18, 1990Assignee: Heumann Pharma GmbH & Co.Inventors: Peter Morsdorf, Helmut Schickaneder, Rolf Herter, Volker Pfahlert, Heidrun Engler, Kurt H. Ahrens
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Patent number: 4954501Abstract: New 6-phenyldihydro-3(2H)-pyridazinones corresponding to the following general formula ##STR1## are described. These compounds are readily prepared in a form suitable for oral administration and are distinguished by a high positive inotropic action and have only a slight effect on blood pressure and cardiac frequency. A process for their preparation and pharmaceutical preparations containing these compounds are also described.Type: GrantFiled: September 21, 1988Date of Patent: September 4, 1990Assignee: Heumann Pharma GmbH & Co.Inventors: Rolf Herter, Peter Morsdorf, Volker Pfahlert, Heidrun Engler, Helmut Schickaneder, Kurt-Henning Ahrens
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Patent number: 4948802Abstract: New guanidine carboxylic acid esters corresponding to the general formula I ##STR1## and a process for the preparation of these compounds are described. The compounds according to the invention are H.sub.2 -agonists optionally having an additional H.sub.1 -antagonistic component. They are distinguished by their improved oral activity. The use of the above-mentioned guanidine carboxylic acid esters and of pharmaceutical preparations containing these esters is also described.Type: GrantFiled: April 11, 1988Date of Patent: August 14, 1990Assignee: Heumann Pharma GmbH & Co.Inventors: Peter Morsdorf, Helmut Schickaneder, Volker Pfahlert, Heidrun Engler, Armin Buschauer, Walter Schunack
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Patent number: 4921856Abstract: New dihydropryidazinone derivatives corresponding to the following formula ##STR1## and a process for their preparation and pharmaceutical preparations containing these compounds are described. These compounds are effective positively inotropic substances with an improved therapeutic profile.Type: GrantFiled: April 1, 1988Date of Patent: May 1, 1990Assignee: Heumann Pharma GmbH & CompanyInventors: Helmut Schickaneder, Peter Morsdorf, Volker Pfahlert, Heidrun Engler, Kurt H. Ahrens