Abstract: A containment system and assembly for the automated production of pharmaceutical or biotechnical articles is provided. The containment system has a housing within which there is an inner chamber having at least one through opening. One or more robots are installed in the chamber, which have a manipulating element on the pivotable arms, which can move within a pivot range. One or more process units are installed in the chamber for the production of the articles. The chamber includes a process space for the production of the articles and a tub-shaped base space for anchoring the feet of the robots to the side surfaces inside the base space. The manipulating element functions as a gripping and transportation device for inspecting the articles or article parts and/or for the production of the articles.

Abstract: A filter system for a containment through which a gas flows, comprising at least one filter unit. First docking means on the filter unit removably connect the filter unit to a receiving port of the containment. The filter unit further has a closure element having an adjusting mechanism to block and open an entry into the filter unit. A drive unit can be connected to the adjusting mechanism. The connection between the adjusting mechanism and the drive unit is preferably dockable. The drive unit has a motor preferably in the form of an electric motor with a pinion or a gear. The transmission ratio of the motor to the transmission part is greater than 1:20, preferably greater than 1:30, for example 1:33. A control unit can switch and monitor the position of a plurality of closure elements according to a program. The adjusting mechanism can also be actuated manually.

Abstract: The arrangement for introducing a desired quantity of decontamination agent into a containment facility comprises a tank as a storage vessel for storing the decontamination agent in liquid form. A metering apparatus having a spray nozzle is directed into the containment facility so as to atomize the decontamination agent. At least one feed line from the ambient air, a compressed air connection and a control unit are provided to operate the metering apparatus. The metering apparatus has a metering container that comprises a storage chamber that has a defined volume for receiving an individual portion of decontamination agent. The storage chamber is provided so as to successively receive a number (n) of portions of decontamination agent from the tank, and the portion respectively held in the storage chamber is introduced by means of the spray nozzle into the containment facility prior to receiving a subsequent portion.

Abstract: Performing a decontamination process by introducing a decontamination agent into a first containment, the first containment is being surrounded by a housing having a primary inlet for admitting a gas medium into the first containment, and a primary outlet for discharging the gas medium from the first containment. The primary outlet leads to an area external to the first containment, into the open atmosphere, or to a second containment and has a gas-technology connection to a first catalyst unit through which the gas medium flows. By means of the at least first catalyst unit, the decontamination agent, which is introduced into the first containment during the decontamination process and enters with the gas medium into the area, open atmosphere or the second containment, can be split into non-critical components and degraded to a non-critical residual concentration.

Abstract: The constructive assembly of the containment means (9) is intended for the automated production of pharmaceutical or biotechnical articles (6). As an end product, a respective article (6) comprises multiple article parts (7). The containment means (9) has a housing (90) within which there is an inner chamber (91) having at least one through opening (917, 919). At most, multiple robots (1, 2) are installed in the chamber (91), which generally have a manipulating element (12, 22) on the pivotable arms (11, 21) thereof, which can move within a pivot range (R1,R2). At most, multiple process units (3) are installed in the chamber (91) for the production of the articles (6). The chamber (91) is formed by a process space (93) for the production of the articles (6) and a tub-shaped base space (92) for anchoring the feet (10, 20) of the robots (1, 2) to the side surfaces (910,912,916,918) inside the base space (92).

Abstract: The invention relates to a filter system designed for a containment (1) through which a gas flows, comprising at least one filter unit (2). First docking means (253) on the filter unit (2) are designed to removably connect the filter unit (2) to a receiving port (17) of the containment (1). The filter unit (2) further has a closure element (27) which can be adjusted by means of an adjusting mechanism (29) and which is used to block and open an entry (203) into the filter unit (2). In order to actuate the adjusting mechanism (29), a drive unit (3) which can be connected to the adjusting mechanism is provided. The connection between the adjusting mechanism (29) of the filter unit (2) and the drive unit (3) is also preferably designed to be dockable. The drive unit (3) has a motor (33) for driving a rotatably mounted transmission part (30), preferably in the form of an electric motor with a pinion or a gear.

Abstract: The catalyst unit (1) for splitting a decontamination agent introduced into a containment for a decontamination process has at least one catalyst element (21). This catalyst element (21) first consists of a carrier material made of aluminum ceramics or activated carbon, and also of a catalytically active component in the form of nanoparticles, applied to the carrier material by means of chemical plating, and made of silver or silver oxide or of a silver and silver oxide mixture. The catalytically active component on the at least one catalyst element (21) is present in the range from 0.05 weight percent to 0.5 weight percent relative to the carrier material. The at least one catalyst element (21) has a catalytically effective surface in the range of up to 320 m2 per gram of used material, as a combination of carrier material plus applied catalytically active component. With the catalyst unit (1), an non-critical concentration of non-degraded decontamination agent of lower than 0.

Abstract: In the arrangement for performing a decontamination process by means of a decontamination agent introduced into a first containment (9), the first containment (9) is surrounded by a housing (90) which has a primary inlet (92) for admitting a gas medium into the first containment (9), and a primary outlet (91) for discharging the gas medium from the first containment (9). The primary outlet (91) of the first containment (9) leads to an area (5;51-53) external to the first containment (9) or into the open atmosphere (69) or to a second containment (9?). The primary outlet (91) has a gas-technology connection to a first catalyst unit (11) through which the gas medium flows.

Abstract: The bioindicator (1) intended for verifying the effectiveness of a sterilization process carried out in a working chamber (90) of a containment system initially has an outer microporous envelope (3) which is permeable to a sterilizing agent (8) but impermeable to microorganisms (20). The carrier (2) accommodated in the interior (10) of the bioindicator (1) is provided with a determined quantity and type of microorganisms (20). The envelope (3) comprises a fixing means (4) which is intended for temporarily and detachably positioning the bioindicator (1) in the working chamber (90). The fixing means (4) is an adhesive strip which is provided with a detachable coating (40). The carrier (2) may be detachably fixed in the interior of the envelope (3) by means of a receptacle (30). The receptacle (30) takes the form of a pocket, an adhesive joint or tear-off point. On the outer surface (34), the envelope (3) has a labeling area (33) to which a symbol carrier (5) may be affixed permanently or detachably.

Abstract: Disclosed is an installation (1) for sterilizing objects (8) by means of a radiation source (50). The installation (1) comprises an irradiation zone (5) in which the radiation source (50) is arranged. An entry zone (3), which is preceded by a feed zone (2), is mounted in front of the irradiation zone (5) while an exit zone (4), which is followed by a subsequent processing zone (9), is mounted behind the irradiation zone (5). A transportation line (6) that is used for conveying the objects (8) extends through the installation (1). One respective shield (7) is associated with the entry zone (3) and the exit zone (4). The entry zone (3) encompasses a first inlet opening (31) that has a passage to the feed zone (2) as well as a second inlet opening (32) which has a passage to the irradiation zone (5). The exit zone (4) has a first outlet (41) that has a passage to the irradiation zone (5) as well as a second outlet opening (42) which has a passage to the subsequent processing zone (9).

Abstract: Disclosed is an installation (1) for sterilizing objects (8) by means of a radiation source (50). The installation (1) comprises an irradiation zone (5) in which the radiation source (50) is arranged. An entry zone (3), which is preceded by a feed zone (2), is mounted in front of the irradiation zone (5) while an exit zone (4), which is followed by a subsequent processing zone (9), is mounted behind the irradiation zone (5). A transportation line (6) that is used for conveying the objects (8) extends through the installation (1). One respective shield (7) is associated with the entry zone (3) and the exit zone (4). The entry zone (3) encompasses a first inlet opening (31) that has a passage to the feed zone (2) as well as a second inlet opening (32) which has a passage to the irradiation zone (5). The exit zone (4) has a first outlet (41) that has a passage to the irradiation zone (5) as well as a second outlet opening (42) which has a passage to the subsequent processing zone (9).

Abstract: The invention relates to a method and an installation for controlling the pressure in a working chamber (10) of an insulator (1), which is shielded from the outer environment (U), during opening or closing of the insulator with respect to the outer environment (U), with the aim of avoiding critical pressure bursts in the working chamber (10). The working chamber (10) is provided with an access for introduction or removal of the product to be treated. Purified air is supplied to the working chamber (10) from a circulating air Zone (11), and air arrives from the working chamber (10) at the circulating air Zone (11) via a returning air channel (14), and the working chamber and the circulating air Zone form an interior space (18). A supply air unit (a3) is provided on the insulator (1) and comprises a supply air ventilator (B) and a blockable first supply air adjusting element (21), mounted between the supply air ventilator (B) and the interior space (18).

Abstract: A system for decontaminating a clean-room has an H2O2 supply device for supplying the clean-room with H2O2 and an H2O2 breakdown device for effecting a chemical breakdown of H2O2 without catalyst in the clean-room. The H2O2 breakdown device comprises a supply vessel filled with gaseous agent which can be introduced via a gas line into the clean-room where it reacts with the H2O2. A valve is placed in the gas line with which the amount of the gaseous agent introduced into the clean-room can be introduced under open-loop or closed-loop control. Owing to the fact that the excess H2O2, that is to say the H2O2 which has not reacted with other materials in the clean-room during the decontamination is broken down in the clean-room itself, it need not be flushed out completely from the clean-room first and broken down afterwards.