Abstract: The present invention relates to NMU-8 analogues that are neuromedin U receptor 2 (NMUR2) agonists, processes for their preparation, pharmaceutical compositions comprising them and their use in therapy, particularly in the treatment or prevention of disease and/or condition associated with or modulated by NMUR2 activation such as obesity or obesity comorbidities.

Abstract: A gradient insulation screw (1) for adjustable fastening of a roofing membrane (2) on a substrate, in particular a steel sheet (3), the gradient insulation screw (1) comprising a drilling tip (4) with a first direction of rotation; following the drilling tip (4), an assembly thread (7) with a second direction of rotation, which differs from the first direction of rotation; following the assembly thread (7), a first thread-free region (8); following the first thread-free region (8), an adjustment thread (9) with the first direction of rotation, the outer diameter of which is greater than the outer diameter of the assembly thread (7) and the drilling tip (4); and following the adjustment thread (9), a tool holder (10) as well as a system (11) for adjustable fastening of a roofing membrane (2) on a substrate with a gradient insulation screw (1) and a holding element (12) and a method for adjustable fastening of a roofing membrane (2) on a substrate using such a system (11).

Abstract: A tire (100) rolls on a surface (105). A method (600) for providing maximum traction coefficient between the tire (100) and the surface (105) include steps for detecting a momentary slip of the tire (100) on the surface (105); detecting a momentary traction coefficient; forming a tuple (410, 510) from the slip and the current traction coefficient; choosing a characteristic curve (205, 305) from a number of predetermined characteristic curves (205, 305) on the basis of the tuple (410, 510), whereby each characteristic curve (205, 305) describes a traction behavior of the tire (100) or a corresponding characteristic pitch; determining the maximum traction coefficient on the basis of the selected characteristic curves (205, 305); and thus providing the maximum traction coefficient.

Abstract: A method for estimating a probability distribution of the maximum coefficient of friction (?) at a current and/or future waypoint (s, s*) of a vehicle. According to the method, a first probability distribution (WV1) for the maximum coefficient of friction (?) at the waypoint (s) of the vehicle is determined by a Bayesian network from a first data set, which is, or was determined, for one, in particular current, waypoint (s) of the vehicle and which characterizes the maximum coefficient of friction (?) at the waypoint (s) of the vehicle.

Abstract: A method for adapting the comfort of a vehicle for a vehicle user. The vehicle has an HMI system with which the user and vehicle interact. A suspension system adapts a position of the user to a roadway. A position planning device plans and regulates movement of the vehicle. A regulating device, which has a memory, is connected to the HMI and a suspension system and the position planning device. According to the method, a target comfort zone for the user is stored in the regulating device memory. A current comfort zone of the user is continuously determined, via the HMI system, and continuously compared with the target comfort zone. Based on comparison results, the regulating device controls the suspension system, the position of the user being adapted to the roadway such that the current comfort zone continues approaching the target comfort zone until the target comfort zone is reached.

Abstract: A tire (100) rolls on a surface (105). A method (600) for providing maximum traction coefficient between the tire (100) and the surface (105) include steps for detecting a momentary slip of the tire (100) on the surface (105); detecting a momentary traction coefficient; forming a tuple (410, 510) from the slip and the current traction coefficient; choosing a characteristic curve (205, 305) from a number of predetermined characteristic curves (205, 305) on the basis of the tuple (410, 510), whereby each characteristic curve (205, 305) describes a traction behavior of the tire (100) or a corresponding characteristic pitch; determining the maximum traction coefficient on the basis of the selected characteristic curves (205, 305); and thus providing the maximum traction coefficient.

Abstract: A method for estimating a probability distribution of the maximum coefficient of friction (?) at a current and/or future waypoint (s, s*) of a vehicle. According to the method, a first probability distribution (WV1) for the maximum coefficient of friction (?) at the waypoint (s) of the vehicle is determined by a Bayesian network from a first data set, which is, or was determined, for one, in particular current, waypoint (s) of the vehicle and which characterizes the maximum coefficient of friction (?) at the waypoint (s) of the vehicle.

Abstract: A bearing mechanism for a transverse leaf spring can be fitted in the area of a vehicle axle and has a holding device for holding the transverse leaf spring and a connecting device via for connecting the holding device to the vehicle. The holding and connecting devices and the transverse spring are designed such that when the transverse spring is in its installed position a cross-sectional plane of the transverse spring, that extends in the vertical and longitudinal directions of the vehicle, can pivot in the area of the mounting fixture during jouncing and rebound of the transverse spring, about a rotational axis that extends in the longitudinal direction. The holding and connecting devices, in the area of the mounting fixture, are designed such that the rotational axis of the cross-sectional plane of the transverse spring is vertically spaced from the neutral fiber of the transverse spring.

Abstract: A method for determining a maximum adhesion limit between a tire and a substrate on which the tire is running in a longitudinal direction. The method includes detecting an instantaneous slip of the tire; detecting an instantaneous longitudinal force on the tire; determining an instantaneous coefficient of adhesion; forming a tuple from the detected slip and determined instantaneous coefficient of adhesion; and determining the adhesion limit. The adhesion limit is determined on the basis of the slope of a straight line passing through the origin and the tuple, if the slip is less than a first threshold value, or on the basis of the slope of a tangent passing through the tuple, if the slip is between the first threshold value and a second threshold value, or directly on the basis of the instantaneous coefficient of adhesion, if the slip is greater than the second threshold value.

Abstract: A method for determining a safe speed (v*) at a future waypoint (s*) of a vehicle moving along a route. In this step, at least one item of route data (in particular the curvature of the curve ?) characterizing the course of the route is determined. In addition, a first probability distribution (Pges) of a coefficient of friction (?) is provided at the current waypoint (s) and/or at the future waypoint (s*) of the vehicle. Subsequently a second probability distribution (Pv) of a vehicle speed (v) at the future waypoint (s*) is determined from the at least one item of route data (?) and from the first probability distribution (Pges). The safe speed (v*) is determined by statistical analysis from the second probability distribution (Pv).

Abstract: A method for checking a motor vehicle comprises steps for transmitting an ID stored in an electronic control device of a transmission of the motor vehicle, to a central facility, the comparison on the part of the central facility of the ID with stored IDs assigned to specific motor vehicles, the transmission of a notification regarding the comparison result from the central facility to the control device, and the issuing on the part of the control device of a signal, if the ID has been located in the stored IDs. The communication comprises an authentication of the central facility thereby.

Abstract: A plate apparatus suitable for heat and/or material exchange has plates (P0, P1, P2, P3) contacting each other flush along a peripheral seal (1) while forming respective intermediate spaces (Z0, Z1, Z2, Z3) and having upper (2, 3) and lower (4, 5) through-flow openings for fluids. A group of these upper and lower through-flow openings (2, 5) is allocated to at least two fluids and is connected by correspondingly placed seals to every second plate intermediate space (Z1, Z3) carrying a flow from top to bottom. In flush upper through-flow openings (2) of plates (P0, P1, P2, P3) a distribution lance (6) runs across these openings and has outlet openings (6a) for at least one of the fluids. It is essential that the outlet openings (6a) are directed into those plate intermediate spaces (Z0, Z2) arranged between the second plate intermediate spaces (Z1, Z3) for the fluids to be mixed.

Abstract: A plate apparatus suitable for heat and/or material exchange has plates (P0, P1, P2, P3) contacting each other flush along a peripheral seal (1) while forming respective intermediate spaces (Z0, Z1, Z2, Z3) and having upper (2, 3) and lower (4, 5) through-flow openings for fluids. A group of these upper and lower through-flow openings (2, 5) is allocated to at least two fluids and is connected by correspondingly placed seals to every second plate intermediate space (Z1, Z3) carrying a flow from top to bottom. In flush upper through-flow openings (2) of plates (P0, P1, P2, P3) a distribution lance (6) runs across these openings and has outlet openings (6a) for at least one of the fluids. It is essential that the outlet openings (6a) are directed into those plate intermediate spaces (Z0, Z2) arranged between the second plate intermediate spaces (Z1, Z3) for the fluids to be mixed.

Abstract: A bearing mechanism for a transverse leaf spring can be fitted in the area of a vehicle axle and has a holding device for holding the transverse leaf spring and a connecting device via for connecting the holding device to the vehicle. The holding and connecting devices and the transverse spring are designed such that when the transverse spring is in its installed position a cross-sectional plane of the transverse spring, that extends in the vertical and longitudinal directions of the vehicle, can pivot in the area of the mounting fixture during jouncing and rebound of the transverse spring, about a rotational axis that extends in the longitudinal direction. The holding and connecting devices, in the area of the mounting fixture, are designed such that the rotational axis of the cross-sectional plane of the transverse spring is vertically spaced from the neutral fiber of the transverse spring.

Abstract: A holder (5) for a spring (2) which has a spring fastening area (10) for fastening the spring (2) to the holder (5) and a wheel carrier fastening area (9) for fastening a wheel carrier (4) to the spring. The holder (5) further has a deformable zone (23) for transmitting force from the spring fastening area (10) to the wheel carrier fastening area (9).

Abstract: Plate heat exchanger consisting of a plate stack (2) and a housing (1) surrounding the plate stack, wherein the plates (2a) are connected with one another in the plate stack (2) in such a manner that a first and at least one further medium can flow alternately through adjacent plate interstices, and the one medium can be conducted to and away from the plate stack (2) by way of through-flow channels that run in the stack direction, while the other medium can be conducted to and away from the plate interstices assigned to it by way of an interstice between housing (1) and plate stack (2) on the outer circumference. It is essential, in this connection, that the following combination of materials is present: The plates (2a) of the plate stack (2) consist, in known manner, of corrosion-resistant material, whereas the housing (1) consists of a non-corrosion-resistant material that has an enamel coating on its inner side, which is impacted by medium.

Abstract: A heat exchanger plate (3a) for a plate-type heat exchanger having throughflow openings (4-7), which are arranged adjacent to one another in the plane of the plate, for fluid media is provided. The heat exchanger plate (3a) is formed from a first material, in particular steel or high-grade steel, and those surfaces (18a, 19a, 20a) of the heat exchanger plate (3a) which come into contact with one of the fluid media are formed from, or lined, with another material which is in particular more corrosion resistant than the first material.

Abstract: A holder (5) for a spring (2) which has a spring fastening area (10) for fastening the spring (2) to the holder (5) and a wheel carrier fastening area (9) for fastening a wheel carrier (4) to the spring. The holder (5) further has a deformable zone (23) for transmitting force from the spring fastening area (10) to the wheel carrier fastening area (9).

Abstract: An axle for a motor vehicle comprises at least a transverse leaf spring (1) attached directly, or via an auxiliary support frame, to a body (9) of the motor vehicle by two first mountings (4), two control arms (2) and two wheel carriers (3). In each case, an end of the transverse leaf spring (1) facing toward a respective wheel (10) of the motor vehicle is rigidly connected to one of the two control arms (2), and both of the two control arms (2) are each orientated substantially in the longitudinal direction of the motor vehicle. Each of the control arms (2) is connected by a second mounting (7) directly, or via an auxiliary support frame, to the body (9) and also connected, by at least one third mounting (5, 6), to one of the wheel carriers (3).

Abstract: A semi-trailing arm axle for a motor vehicle which comprises a semi-trailing arm (1) for each wheel (4) of the axle. Each semi-trailing arm (1) is flexible about the vertical axis and is mounted to the body or on a support frame by at least one mounting (2, 3). Each wheel (4) of the axle is connected to its respective flexible semi-trailing arm (1) by way of at least one wheel bearing (5), and the flexible semi-trailing arm (1) is the sole wheel-guiding element.