Patents by Inventor Volkhart Li
Volkhart Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10214526Abstract: The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: February 2, 2016Date of Patent: February 26, 2019Assignee: Bayer Pharma AktiengesellschaftInventors: Alexandros Vakalopoulos, Damian Brockschnieder, Frank Wunder, Johannes-Peter Stasch, Tobias Marquardt, Lisa Dietz, Min Jian Volkhart Li
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Patent number: 10150773Abstract: The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides of general formula (I) to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: February 2, 2016Date of Patent: December 11, 2018Assignee: Bayer Pharma AktiengesellschaftInventors: Alexandros Vakalopoulos, Damian Brockschnieder, Frank Wunder, Johannes-Peter Stasch, Tobias Marquardt, Lisa Dietz, Min Jian Volkhart Li
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Publication number: 20180148418Abstract: The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.Type: ApplicationFiled: May 2, 2016Publication date: May 31, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Knut EIS, Jens ACKERSTAFF, Sarah WAGNER, Philipp BUCHGRABER, Detlev SÜLZLE, Simon HOLTON, Eckhard BENDER, Volkhart LI, Ningshu LIU, Franziska SIEGEL, Philip LIENAU, Michaela BAIRLEIN, Franz VON NUSSBAUM, Simon Anthony HERBERT, Marcus KOPPITZ
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Publication number: 20180037580Abstract: The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: February 2, 2016Publication date: February 8, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Alexandros VAKALOPOULOS, Damian BROCKSCHNIEDER, Frank WUNDER, Johannes-Peter STASCH, Tobias MARQUARDT, Lisa DIETZ, Min Jian Volkhart LI
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Publication number: 20180022751Abstract: The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: February 2, 2016Publication date: January 25, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Alexandros VAKALOPOULOS, Damian BROCKSCHNIEDER, Frank WUNDER, Johannes-Peter STASCH, Tobias MARQUARDT, Lisa DIETZ, Min Jian Volkhart LI
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Patent number: 8343987Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.Type: GrantFiled: December 8, 2009Date of Patent: January 1, 2013Assignee: Bayer Intellectual Property GmbHInventors: Heike Gielen-Haertwig, Barbara Albrecht, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Patent number: 8227511Abstract: The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.Type: GrantFiled: March 7, 2007Date of Patent: July 24, 2012Assignee: Bayer Intellectual Property GmbHInventors: Carsten Schmeck, Hilmar Bischoff, Volkhart Li, Klemens Lustig, Michael Thutewohl, Alexandros Vakalopoulos, Olaf Weber
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Publication number: 20120142728Abstract: The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.Type: ApplicationFiled: February 16, 2012Publication date: June 7, 2012Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hilmar BISCHOFF, Heike GIELEN-HAERTWIG, Volkhart LI, Carsten SCHMECK, Michael THUTEWOHL, Alexandros VAKALOPOULOS, Olaf WEBER, Martina WUTTKE
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Patent number: 8124775Abstract: The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.Type: GrantFiled: December 15, 2005Date of Patent: February 28, 2012Assignee: Bayer Pharma AktiengesellschaftInventors: Hilmar Bischoff, Heike Gielen-Haertwig, Volkhart Li, Carsten Schmeck, Michael Thutewohl, Alexandros Vakalopoulos, Olaf Weber, Martina Wuttke
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Patent number: 8101615Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.Type: GrantFiled: February 15, 2005Date of Patent: January 24, 2012Assignee: Bayer Pharma AktiengesellschaftInventors: Heike Gielen-Haertwig, Barbara Albrecht, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Patent number: 8097629Abstract: The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.Type: GrantFiled: February 5, 2005Date of Patent: January 17, 2012Assignee: Bayer Pharma AktiengesellschaftInventors: Heike Gielen-Haertwig, Barbara Albrecht, Marcus Bauser, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Patent number: 8039629Abstract: The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.Type: GrantFiled: December 15, 2005Date of Patent: October 18, 2011Assignee: Bayer Pharma AktiengesellschaftInventors: Hilmar Bischoff, Heike Gielen-Haertwig, Volkhart Li, Carsten Schmeck, Michael Thutewohl, Alexandros Vakalopoulos, Olaf Weber, Martina Wuttke
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Patent number: 7893073Abstract: The invention relates to novel 3,4-dihydropyrimidin-2(1H)-one derivatives having the formula processes for their preparation, and their use in compositions, and in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.Type: GrantFiled: February 15, 2005Date of Patent: February 22, 2011Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Heike Gielen-Haertwig, Barbara Albrecht, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Publication number: 20100184788Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.Type: ApplicationFiled: December 8, 2009Publication date: July 22, 2010Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Heike GIELEN-HAERTWIG, Barbara Albrecht, Jörg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Publication number: 20100003709Abstract: This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.Type: ApplicationFiled: December 13, 2005Publication date: January 7, 2010Applicant: Bayer HealthCare AGInventors: Peter Reinemer, Heike Gielen-Haertwig, Ulrich Rosentreter, Volkhart Li, Axel Harrenga, Dietmar Schomburg, Karsten Niefind, Guido Hansen
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Publication number: 20090306197Abstract: The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.Type: ApplicationFiled: March 7, 2007Publication date: December 10, 2009Applicant: Bayer Healthcare AGInventors: Carsten Schmeck, Hilmar Bischoff, Volkhart Li, Klemens Lustig, Michael Thutewohl, Alexandros Vakalopoulos, Olaf Weber
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Publication number: 20080255068Abstract: The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.Type: ApplicationFiled: December 15, 2005Publication date: October 16, 2008Applicant: Bayer HealthCare AGInventors: Hilmar Bischoff, Heike Gielen-Haertwig, Volkhart Li, Carsten Schmeck, Michael Thutewohl, Alexandros Vakalopoulos, Olaf Weber, Martina Wuttke
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Publication number: 20080194609Abstract: The present application relates to novel tetrahydroquinoline derivatives, to a process for their preparation, to their use on their own or in combination for treating and/or preventing diseases and to their use for preparing medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinemias, dyslipidemias, hypertriglyceridemias, hyperlipidemias, hypercholesterolemias and arteriosclerosis.Type: ApplicationFiled: December 10, 2005Publication date: August 14, 2008Applicant: Bayer HeathCare AGInventors: Hilmar Bischoff, Heike Gielen-Haertwig, Volkhart Li, Carsten Schmeck, Michael Thutewohl, Martina Wuttke, Alexandros Vakalopoulos, Olaf Weber
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Publication number: 20080064704Abstract: The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.Type: ApplicationFiled: February 15, 2005Publication date: March 13, 2008Applicant: Bayer HealthCare AGInventors: Heike Gielen-Haertwig, Barbara Albrecht, Jorg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan
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Publication number: 20080045541Abstract: The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.Type: ApplicationFiled: February 5, 2005Publication date: February 21, 2008Applicant: Bayer-HealthCare AGInventors: Heike Gielen-Haertwig, Barbara Albrecht, Marcus Bauser, Jorg Keldenich, Volkhart Li, Josef Pernerstorfer, Karl-Heinz Schlemmer, Leila Telan