Patents by Inventor Volkhart Min-Jian Li

Volkhart Min-Jian Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMIDO-SUBSTITUTED AZOLE COMPOUNDS
    Publication number: 20170020886
    Abstract: The present invention relates to amido-substituted azole compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7 and R8 are as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: April 1, 2015
    Publication date: January 26, 2017
    Inventors: Knut EIS, Jens ACKERSTAFF, Sarah WAGNER, Daniel BASTING, Stefanü GOLZ, Eckhard BENDER, Volkhart Min-Jian LI, Philip LIENAU, Ningshu LIU, Franziska SIEGEL, Marcus BAUSER, Detlev SÜLZLE, Simon HOLTON, Michaela BAIRLEIN, Philipp BUCHGRABER, Jözsef BÁLINTT
  • ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF
    Publication number: 20160362408
    Abstract: The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: December 1, 2014
    Publication date: December 15, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Alexandros VAKALOPOULOS, Ingo HARTUNG, Niels LINDNER, Rolf JAUTELAT, Jorma HASSFELD, Dirk SCHNEIDER, Frank WUNDER, Johannes-Peter STASCH, Gorden REDLICH, Volkhart Min-Jian LI, Eva Maria BECKER-PELSTER, Andreas KNORR
  • 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES
    Publication number: 20160347770
    Abstract: The present application relates to novel 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: February 17, 2015
    Publication date: December 1, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Alexandros VAKALOPOULOS, Alexey GROMOV, Markus FOLLMANN, Damian BROCKSCHNIEDER, Johannes-Peter STASCH, Tobias MARQUARDT, Adrian TERSTEEGEN, Frank WUNDER, Gorden REDLICH, Dieter LANG, Volkhart Min-Jian LI
  • Branched 3-phenylpropionic acid derivatives and their use
    Publication number: 20160264515
    Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
    Type: Application
    Filed: May 18, 2016
    Publication date: September 15, 2016
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Michael HAHN, Thomas LAMPE, Johannes-Peter STASCH, Karl-Heinz SCHLEMMER, Frank WUNDER, Volkhart Min-Jian LI, Eva-Maria BECKER, Friederike STOLL, Andreas KNORR, Elisabeth WOLTERING
  • Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof
    Patent number: 9422285
    Abstract: The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: August 23, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros Vakalopoulos, Markus Follmann, Philipp Buchgraber, Alexey Gromov, Ingo Hartung, Niels Lindner, Frank Wunder, Johannes-Peter Stasch, Tobias Marquardt, Gorden Redlich, Lisa Dietz, Volkhart Min-Jian Li
  • Substituted aminoindane- and aminotetralinecarboxylic acids and the use thereof
    Patent number: 9387203
    Abstract: The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: July 12, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Walter Hübsch, Michael Hahn, Alexandros Vakalopoulos, Volkhart Min-Jian Li, Frank Wunder, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Friederike Stoll, Niels Lindner, Eva Maria Becker-Pelster
  • SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF
    Publication number: 20160185775
    Abstract: The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: August 5, 2014
    Publication date: June 30, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Alexandros VAKALOPOULOS, Markus FOLLMANN, Philipp BUCHGRABER, Alexey GROMOV, Ingo HARTUNG, Niels LINDNER, Frank WUNDER, Johannes-Peter STASCH, Tobias MARQUARDT, Gorden REDLICH, Lisa DIETZ, Volkhart Min-Jian LI
  • SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF
    Publication number: 20160176880
    Abstract: The present application relates to novel substituted imidazo[1,2-a]pyrazinecarboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: August 5, 2014
    Publication date: June 23, 2016
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros VAKALOPOULOS, Markus FOLLMANN, Ingo HARTUNG, Philipp BUCHGRABER, Rolf JAUTELAT, Niels LINDNER, Frank WUNDER, Johannes-Peter STASCH, Gorden REDLICH, Lisa Dietz, Volkhart Min-Jian LI
  • Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD
    Patent number: 9359362
    Abstract: The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: June 7, 2016
    Assignee: Bayer Intellectual Property Gmbh
    Inventors: Franz Von Nussbaum, Dagmar Karthaus, Sonja Anlauf, Martina Delbeck, Volkhart Min-Jian Li, Daniel Meibom, Klemens Lustig
  • BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF
    Publication number: 20160145271
    Abstract: The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: July 8, 2014
    Publication date: May 26, 2016
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros VAKALOPOULOS, Alexey GROMOV, Markus FOLLMANN, Damian BROCKSCHNIEDER, Johannes-Peter STASCH, Tobias MARQUARDT, Adrian TERSTEEGEN, Frank WUNDER, Gorden REDLICH, Dieter LANG, Volkhart Min-Jian LI
  • SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE
    Publication number: 20160129004
    Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 12, 2016
    Applicant: ADVERIO PHARMA GMBH
    Inventors: Markus FOLLMANN, Johannes-Peter STASCH, Gorden REDLICH, Jens ACKERSTAFF, Nils GRIEBENOW, Walter KROH, Andreas KNORR, Eva-Maria BECKER, Frank WUNDER, Volkhart Min-Jian Li, Elke HARTMANN, Joachim MITTENDORF, Karl-Heinz SCHLEMMER, Rolf JAUTELAT, Donald BIERER
  • 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE
    Publication number: 20160122341
    Abstract: The present application relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: June 4, 2014
    Publication date: May 5, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Alexandros VAKALOPOULOS, Markus FOLLMANN, Ingo HARTUNG, Philipp BUCHGRABER, Alexey GROMOV, Niels LINDNER, Frank WUNDER, Johannes-Peter STASCH, Gorden REDLICH, Volkhart Min-Jian LI
  • N-[3-(2-carboxyethyl)phenyl]piperidin-1-ylacetamide derivatives and use thereof as activators of soluble guanylate cyclase
    Patent number: 9309198
    Abstract: The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: April 12, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Thomas Lampe, Michael Hahn, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Sherif El Sheikh, Volkhart Min-Jian Li, Eva Maria Becker-Pelster, Friederike Stoll, Andreas Knorr
  • Substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines and use thereof
    Patent number: 9309239
    Abstract: The present application relates to novel substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for preparing Medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: April 12, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Andreas Knorr, Frank Wunder, Volkhart Min-Jian Li, Joachim Mittendorf, Karl-Heinz Schlemmer, Rolf Jautelat
  • Substituted 5-fluoro-1H-pyrazolopyridines and their use
    Patent number: 9266885
    Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: February 23, 2016
    Assignee: ADVERIO PHARMA GMBH
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Walter Kroh, Andreas Knorr, Eva-Maria Becker, Frank Wunder, Volkhart Min-Jian Li, Elke Hartmann, Joachim Mittendorf, Karl-Heinz Schlemmer, Rolf Jautelat, Donald Bierer
  • Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases
    Patent number: 9216978
    Abstract: The present application relates to novel fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 22, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Andreas Knorr, Frank Wunder, Volkhart Min-Jian Li, Walter Kroh, Lars Bärfacker
  • 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof
    Patent number: 9174997
    Abstract: The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 3, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Franz Von Nussbaum, Dagmar Karthaus, Sonja Anlauf, Martina Delbeck, Volkhart Min-Jian Li, Daniel Meibom, Klemens Lustig, Jens Schamberger
  • Substituted imidazopyridines and the use thereof
    Patent number: 9150580
    Abstract: The present application relates to novel substituted imidazopyridazines having the following formula (I): to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: October 6, 2015
    Assignees: BAYER INTELLECTUAL PROPERTY GMBH, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Alexander Straub, Jens Ackerstaff, Nils Griebenow, Andreas Knorr, Frank Wunder, Volkhart Min-Jian Li
  • AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE
    Publication number: 20150274719
    Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: November 4, 2013
    Publication date: October 1, 2015
    Inventors: Alexandros Vakalopoulos, Markus Follmann, Ingo Hartung, Philipp Buchgraber, Rolf Jautelat, Jorma Hassfeld, Niels Lindner, Alexey Gromov, Frank Wunder, Johannes-Peter Stasch, Gorden Redlich, Volkhart Min-Jian Li, Eva Maria Becker-Pelster, Andreas Knorr
  • Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
    Patent number: 9126998
    Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: September 8, 2015
    Assignee: BAYER PHARMA AG
    Inventors: Alexandros Vakalopoulos, Markus Follmann, Ingo Hartung, Philipp Buchgraber, Rolf Jautelat, Jorma Haβfeld, Niels Lindner, Frank Wunder, Johannes-Peter Stasch, Gorden Redlich, Volkhart Min-Jian Li, Eva-Maria Becker, Andreas Knorr