Patents by Inventor Volkmar Gunzler-Pukall

Volkmar Gunzler-Pukall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
    Patent number: 5679583
    Abstract: It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III), to determine said peptide with great accuracy. It is also, possible, with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present in Col 1, to determine with great accuracy said procollagen peptide in body fluids.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: October 21, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dietrich Brocks, Jurgen Punter, Helmut Strecker, deceased, Rupert Timpl, Volkmar Gunzler-Pukall, Henning Hachmann
  • N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamines
    Patent number: 5519038
    Abstract: The invention relates to N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides of the formula I ##STR1## wherein R.sup.1, R.sup.2, n, R.sup.1', R.sup.2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: May 21, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals
    Patent number: 5482953
    Abstract: The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerrit Schubert, Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments
    Patent number: 5428046
    Abstract: The invention relates to acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides of the formula I ##STR1## in which______________________________________ A = R.sup.3 and B = X--NR.sup.5 R.sup.6 or B = R.sup.3 and A = X--NR.sup.5 R.sup.6. ______________________________________The compounds are suitable as medicaments against fibrotic diseases.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar Gunzler-Pukall, Karl-Heinz Baringhaus
  • 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
    Patent number: 5260323
    Abstract: 2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and their use
    Patent number: 5240921
    Abstract: The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: August 31, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Oxalylamino acid derivatives and their use as medicaments for inhibiting proline hydroxylase
    Patent number: 5204338
    Abstract: The invention relates to oxalylamino acid derivatives of the formula I ##STR1## in which R and R' are identical or different and are C.sub.1 -C.sub.6 -alkyl or hydrogen,R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.3 -alkoxy, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, aryl, SH, NH.sub.2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH.sub.2orR.sup.1 and R.sup.2 together are a C.sub.2 -C.sub.4 -alkylene chain and the compounds in their predominantly pure D- and L-form and the physiologically tolerable salts.The compounds are distinguished as excellent inhibitors of prolyl hydroxylase and lysine hydroxylase.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: April 20, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Harald Burghard, Volkmar Gunzler-Pukall
  • Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compounds
    Patent number: 5130317
    Abstract: Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compoundsThe invention relates to pyrimidine-4,6-dicarboxylic acid diamides of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can be employed as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: July 14, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall, Stephan Henke