Patents by Inventor Volkmar Guenzler-Pukall

Volkmar Guenzler-Pukall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20070155784
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: October 13, 2006
    Publication date: July 5, 2007
    Inventors: Michael Arend, Lee Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • Stabilization of hypoxia inducible factor (HIF) alpha
    Publication number: 20060270699
    Abstract: The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
    Type: Application
    Filed: July 28, 2006
    Publication date: November 30, 2006
    Applicant: FibroGen, Inc.
    Inventors: Volkmar Guenzler-Pukall, Thomas Neff, Qingjian Wang, Michael Arend, Lee Flippin, Alex Melekhov
  • Stabilization of hypoxia inducible factor (HIF) alpha
    Publication number: 20060258660
    Abstract: The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
    Type: Application
    Filed: July 28, 2006
    Publication date: November 16, 2006
    Applicant: FibroGen, Inc.
    Inventors: Volkmar Guenzler-Pukall, Thomas Neff, Qingjian Wang, Michael Arend, Lee Flippin, Alex Melekhov
  • Stabilization of hypoxia inducible factor (HIF) alpha
    Publication number: 20060258702
    Abstract: The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
    Type: Application
    Filed: July 28, 2006
    Publication date: November 16, 2006
    Applicant: FibroGen, Inc.
    Inventors: Volkmar Guenzler-Pukall, Thomas Neff, Qingjian Wang, Michael Arend, Lee Flippin, Alex Melekhov
  • Cytoprotection through the use of hif hydroxylase inhibitors
    Publication number: 20060251638
    Abstract: The invention relates to methods for conferring cytoprotection, or for inducing a cytoprotective effect, by administering a compound that inhibits HIF hydroxylase. Compounds for use in these methods are also provided.
    Type: Application
    Filed: June 4, 2004
    Publication date: November 9, 2006
    Inventors: Volkmar Guenzler-Pukall, Stephen Klaus, David Liu, Todd Seeley
  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20060217416
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: May 26, 2006
    Publication date: September 28, 2006
    Inventors: Michael Arend, Lee Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • Methods of increasing endogenous erythropoietin (EPO)
    Publication number: 20060183695
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: April 17, 2006
    Publication date: August 17, 2006
    Applicant: FibroGen, Inc.
    Inventors: Stephen Klaus, Al Lin, Thomas Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael Arend, Lee Flippin, Alex Melekhov
  • Methods of increasing endogenous erythropoietin (EPO)
    Publication number: 20060178317
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: April 17, 2006
    Publication date: August 10, 2006
    Applicant: FibroGen, Inc.
    Inventors: Stephen Klaus, Al Lin, Thomas Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael Arend, Lee Flippin, Alex Melekhov
  • Methods of increasing endogenous erythropoietin (EPO)
    Publication number: 20060178316
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: April 17, 2006
    Publication date: August 10, 2006
    Applicant: FibroGen, Inc.
    Inventors: Stephen Klaus, Al Lin, Thomas Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael Arend, Lee Flippin, Alex Melekhov
  • Enhanced erythropoiesis and iron metabolism
    Publication number: 20050020487
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 27, 2005
    Inventors: Stephen Klaus, Christopher Molineaux, Thomas Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd Seeley, Robert Stephenson
  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20040254215
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: June 4, 2004
    Publication date: December 16, 2004
    Applicant: FibroGen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric D. Turtle, Xiaohui Du
  • Fat regulation
    Publication number: 20040235082
    Abstract: The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
    Type: Application
    Filed: December 4, 2003
    Publication date: November 25, 2004
    Inventors: Patrick D. Fourney, Volkmar Guenzler-Pukall, Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Todd W. Seeley
  • Treatment of diabetes
    Publication number: 20040204356
    Abstract: The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or preventing diabetes, hyperglycemia, and disorders and conditions associated with altered or impaired glucose metabolism are also provided.
    Type: Application
    Filed: December 4, 2003
    Publication date: October 14, 2004
    Inventors: Volkmar Guenzler-Pukall, Stephen J. Klaus, Ingrid Langsetmo Parobok, Todd W. Seeley
  • Stabilization of hypoxia inducible factor (HIF) alpha
    Publication number: 20030176317
    Abstract: The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
    Type: Application
    Filed: December 6, 2002
    Publication date: September 18, 2003
    Inventors: Volkmar Guenzler-Pukall, Thomas B. Neff, Qingjian Wang, Michael P. Arend, Lee A. Flippin, Alex Melekhov
  • Methods of increasing endogenous erythropoietin (EPO)
    Publication number: 20030153503
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: December 6, 2002
    Publication date: August 14, 2003
    Inventors: Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael P. Arend, Lee A. Flippin, Alex Melekhov