Patents by Inventor Volney Sheen

Volney Sheen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR HOMOLOGY DIRECTED REPAIR
    Publication number: 20220220468
    Abstract: Described are methods of homology directed repair (e.g., for treating a disease or disorder) and fusion proteins, polynucleotides (e.g., guide polynucleotides (e.g., guide RNAs) and polynucleotides encoding the fusion proteins), vectors containing the polynucleotides, viral or non-viral delivery vehicles containing the vectors, and compositions (e.g., pharmaceutical compositions) containing the same for use in methods of homology directed repair.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 14, 2022
    Inventors: Volney SHEEN, Gewei LIAN
  • METHODS AND KITS FOR DIAGNOSIS AND TREATMENT OF CELL-CELL JUNCTION RELATED DISORDERS
    Publication number: 20100280104
    Abstract: We have discovered that loss of Filamin A function results in weakened cell-cell junctions and vascular defects in genetically engineered mice. In addition, we have shown that patients with mutations in the gene coding for Filamin A exhibit high rates of cardiovascular disorders. On the basis of this discovery, the present invention features methods and kits for diagnosis of cell-cell junction related disorders (e.g.
    Type: Application
    Filed: December 3, 2007
    Publication date: November 4, 2010
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Christopher A. Walsh, Yuanyi Feng, Volney Sheen