Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease.

Abstract: Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: A haptic actuator may include a housing that includes a ferromagnetic material having a first heat conductance, and a coil carried by the housing in a medial portion thereof and generating waste heat when electrically powered. The haptic actuator may also include a field member movable within the housing responsive to the coil. The field member may include at least one permanent magnet establishing a magnetic path with the housing. A heat spreading layer may be thermally coupled to the housing adjacent the coil. The heat spreading layer may have a second heat conductance greater than the first heat conductance to spread the waste heat from the coil to adjacent portions of the housing.

Abstract: According to some embodiments, a haptic feedback module for generating a haptic feedback event is described. The haptic feedback module includes an enclosure having walls that define a cavity. The enclosure is capable of carrying operational components within the cavity that include a frame that includes tungsten, a magnetic coil element that is capable of generating a magnetic field, a magnetic element that is carried within an aperture of the frame, linear-actuation end stops that are welded to a first end of the frame and a second end of the frame that opposes the first end, and springs that couple together the walls of the enclosure to the linear-actuation end stops.

Abstract: A haptic actuator may include a housing that includes a ferromagnetic material having a first heat conductance, and a coil carried by the housing in a medial portion thereof and generating waste heat when electrically powered. The haptic actuator may also include a field member movable within the housing responsive to the coil. The field member may include at least one permanent magnet establishing a magnetic path with the housing. A heat spreading layer may be thermally coupled to the housing adjacent the coil. The heat spreading layer may have a second heat conductance greater than the first heat conductance to spread the waste heat from the coil to adjacent portions of the housing.

Abstract: According to some embodiments, a haptic feedback module for generating a haptic feedback event is described. The haptic feedback module includes an enclosure having walls that define a cavity. The enclosure is capable of carrying operational components within the cavity that include a frame that includes tungsten, a magnetic coil element that is capable of generating a magnetic field, a magnetic element that is carried within an aperture of the frame, linear-actuation end stops that are welded to a first end of the frame and a second end of the frame that opposes the first end, and springs that couple together the walls of the enclosure to the linear-actuation end stops.

Abstract: An interactive computer based essay system that prompts students, step-by-step, field-by-field, to write a completed essay is disclosed. The system breaks down the essay-writing process into simple steps using unique processes and algorithms. It also integrates several external elements to ensure student success with writing. The essay system follows three key steps: 1) Follow the instructions based on the three key algorithms: “ABCD Algorithm”, “Advanced TEEEEC Algorithm”, and “Thesis Algorithm”; 2) Write an essay; and 3) Coach provides feedback. The platform allows for progress tracking so that customers know how students are performing with the system at all times. Parents and instructors, therefore, have the ability to gauge and guide improvement, as well as identify critical areas of focus for the student. Coaches are readily available to provide feedback.

Abstract: The present invention discloses an interactive virtual classroom for scripted self-directed learning and education. While self-directed learning is often unidirectional or bidirectional, this application features a multi-directional learning approach. The multidirectional approach involves interaction with virtual classmates that are programmed with artificial intelligence (AI). Interaction can be between the instructor and the user student, the user student and the AI students, the instructor and the AI students, between the AI students. The content provided within the classroom is scripted and customized depending on what is being taught. An interactive virtual classroom allowing for self-directed scripted learning is disclosed. While self-directed learning is often unidirectional or bidirectional, this application features a multidirectional learning approach. The multidirectional approach involves interaction with virtual classmates that are programmed with artificial intelligence (AI).