Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating polycythemia, and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: The present disclosure provides amine based compounds for inhibiting matriptase 2, or a mutant thereof, and compositions and methods of use thereof.

Abstract: The present embodiments are directed to methods of using a crystalline form (such as form A, B, or C, or a methylparaben cocrystal form) or an amorphous form of Bitopertin, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT 1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for modulating the activity of Matriptase 2 (“Mat-2”), or a mutant thereof. The present disclosure also provides pharmaceutically acceptable compositions comprising compounds of the present disclosure and methods of using said compositions in the treatment of various disease and disorders related to Mat-2.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating polycythemia, and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease.

Abstract: Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: An interactive computer based essay system that prompts students, step-by-step, field-by-field, to write a completed essay is disclosed. The system breaks down the essay-writing process into simple steps using unique processes and algorithms. It also integrates several external elements to ensure student success with writing. The essay system follows three key steps: 1) Follow the instructions based on the three key algorithms: “ABCD Algorithm”, “Advanced TEEEEC Algorithm”, and “Thesis Algorithm”; 2) Write an essay; and 3) Coach provides feedback. The platform allows for progress tracking so that customers know how students are performing with the system at all times. Parents and instructors, therefore, have the ability to gauge and guide improvement, as well as identify critical areas of focus for the student. Coaches are readily available to provide feedback.

Abstract: The present invention discloses an interactive virtual classroom for scripted self-directed learning and education. While self-directed learning is often unidirectional or bidirectional, this application features a multi-directional learning approach. The multidirectional approach involves interaction with virtual classmates that are programmed with artificial intelligence (AI). Interaction can be between the instructor and the user student, the user student and the AI students, the instructor and the AI students, between the AI students. The content provided within the classroom is scripted and customized depending on what is being taught. An interactive virtual classroom allowing for self-directed scripted learning is disclosed. While self-directed learning is often unidirectional or bidirectional, this application features a multidirectional learning approach. The multidirectional approach involves interaction with virtual classmates that are programmed with artificial intelligence (AI).