Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

Abstract: The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to the invention which consists of a support and a metering element integrated into the support for taking up a defined volume of sample liquid and a closed liquid compartment located on the support which contains a defined volume of a liquid where the liquid compartment on the support can be opened.

Abstract: A method and level sensor apparatus for detecting contact of a pipetting needle with at least a liquid contained in a vessel are disclosed. The apparatus provides a pipetting needle made of a material suitable for transmitting ultrasonic waves, a needle holder for holding the needle, a electromechanical transducer for generating ultrasonic pulses to be transmitted towards the needle, for receiving echo pulses reflected at the tip of the needle, and for generating an electrical output signal representative of the echo pulses, and electronic circuit means for generating and applying a driving signal to the transducer, which generates corresponding pulses which are transmitted to the needle towards the tip thereof, and for monitoring and evaluating the output signal to detect the position of the needle at which the tip of the needle contacts the liquid and for providing a resulting signal representative of the result of said evaluation.

Abstract: A method and level sensor apparatus for detecting contact of a pipetting needle with at least a liquid contained in a vessel are disclosed. The apparatus provides a pipetting needle made of a material suitable for transmitting ultrasonic waves, a needle holder for holding the needle, a electromechanical transducer for generating ultrasonic pulses to be transmitted towards the needle, for receiving echo pulses reflected at the tip of the needle, and for generating an electrical output signal representative of the echo pulses, and electronic circuit means for generating and applying a driving signal to the transducer, which generates corresponding pulses which are transmitted to the needle towards the tip thereof, and for monitoring and evaluating the output signal to detect the position of the needle at which the tip of the needle contacts the liquid and for providing a resulting signal representative of the result of said evaluation.

Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

Abstract: A level sensor apparatus is disclosed for detecting contact of a pipetting needle with a liquid contained in a vessel. The apparatus includes a sensor head made up of a pipetting needle, a needle holder, and an electromechanical transducer. The sensor head also has an associated mechanical resonance frequency. An electrical signal generator is used to generate a driving signal which when applied to the electromechanical transducer causes vibration of the pipetting needle at the resonance frequency. A measurement device is used to measure a parameter of a vibration signal indicative of the mechanical vibration of the pipetting needle when it is driven by the driving signal. An electronic circuit and associated computer software is provided to evaluate variation of the vibration signal with time and thus detect contact of the pipetting needle with a liquid contained in the vessel.

Abstract: The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to the invention which consists of a support and a metering element integrated into the support for taking up a defined volume of sample liquid and a closed liquid compartment located on the support which contains a defined volume of a liquid where the liquid compartment on the support can be opened.

Abstract: A level sensor apparatus is disclosed for detecting contact of a pipetting needle with a liquid contained in a vessel. The apparatus includes a sensor head made up of a pipetting needle, a needle holder, and an electromechanical transducer. The sensor head also has an associated mechanical resonance frequency. An electrical signal generator is used to generate a driving signal which when applied to the electromechanical transducer causes vibration of the pipetting needle at the resonance frequency. A measurement device is used to measure a parameter of a vibration signal indicative of the mechanical vibration of the pipetting needle when it is driven by the driving signal. An electronic circuit and associated computer software is provided to evaluate variation of the vibration signal with time and thus detect contact of the pipetting needle with a liquid contained in the vessel.

Abstract: The present invention is related to a microfluidic device capable of conveying a liquid by capillary forces. The microfluidic device comprises a microfluidic channel system comprising i) a liquid supply compartment; ii) a first channel connected to the liquid supply compartment, having at least one non-closing valve located downstream of the liquid supply compartment; and iii) a second channel. The second channel branches-off from the first channel downstream of the liquid supply compartment but upstream of the at least one non-closing valve and which re-unites with the first channel at the location of the non-closing valve to form an outlet channel. The second channel does not contain any non-closing or closing valve thus creating an unobstructed liquid flow path connecting the liquid supply compartment with the outlet channel.