Abstract: A thermal spray apparatus to apply coatings to external and internal surfaces in restricted areas is provided. The apparatus includes: a combustion chamber having a primary passage for combustion of fuel received through a fuel input line with oxygen or air received through an oxidizing gas input line; a divergence section located downstream of the combustion chamber; an elbow housing located downstream of the divergence section. A nozzle housing retaining a nozzle having an injection zone and a nozzle throat; a convergence section retained between the elbow housing and the nozzle housing; a feedstock injector for the injection of feedstock material into the injection zone of said nozzle; and a plurality of passageways extending through the combustion chamber, the divergence section, the elbow housing, and the convergence section for passing a coolant therethrough.

Abstract: Provided herein, in some embodiments, are methods and compositions for the treatment of Charcot-Marie-Tooth disease.

Abstract: The present disclosure provides for a composition which may be used for the solubilization of an agent or the oral administration of an agent, the composition comprising, a lysophosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lysophosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lysophosphatidyl compound, a monoglyceride and a free fatty acid.

Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

Abstract: The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

Abstract: Provided herein, in some embodiments, are methods and compositions for the treatment of Charcot-Marie-Tooth disease, comprising an inhibitor of a GCN2 pathway component.

Abstract: RNA interference-based methods and products for inhibiting the expression of mutant Glycyl-tRNA Synthetase (GARS) genes are provided. Delivery vehicles such as recombinant adeno-associated viruses deliver DMAs encoding GARS microRNAs, as well as a replacement GARS gene that is resistant to knock down by the microRNAs. The methods have application in the treatment of N diseases or disorders associated with mutant GARS including, but not limited to, Charcot-Marie-Tooth Disease Type 2D (CMT2D).

Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

Abstract: A thermal spray apparatus to apply coatings to external and internal surfaces in restricted areas is provided. The apparatus includes: a combustion chamber having a primary passage for combustion of fuel received through a fuel input line with oxygen or air received through an oxidizing gas input line; a divergence section located downstream of the combustion chamber; an elbow housing located downstream of the divergence section. A nozzle housing retaining a nozzle having an injection zone and a nozzle throat; a convergence section retained between the elbow housing and the nozzle housing; a feedstock injector for the injection of feedstock material into the injection zone of said nozzle; and a plurality of passageways extending through the combustion chamber, the divergence section, the elbow housing, and the convergence section for passing a coolant therethrough.

Abstract: A thermal spray apparatus to apply coatings to external and internal surfaces in restricted areas is provided. The apparatus includes: a fuel input line; an oxidizing gas input line; coolant input and outlet; a combustion chamber that facilitates primary combustion; a diverging section that splits the primary combustion flow into two or more streams; an elbow section that redirects the combustion streams; a convergent/divergent nozzle; a convergence section that recombines the combustion streams into a single combustion stream within an injection zone of the convergent/divergent nozzle; and a feedstock injector for the injection of feedstock material for forming said coatings into said injection zone of the convergent/divergent nozzle; wherein the convergent/divergent nozzle has a nozzle throat downstream of the injection zone whereby in operation the injection pressure of the feedstock material upstream of the nozzle throat approximates the pressure of the combustion stream within the injection zone.

Abstract: The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

Abstract: The present invention includes methods and compositions for ameliorating symptoms or treating one or more adverse reactions triggered by infectious diseases or disease conditions that trigger a widespread release of cytokines in a subject comprising the steps of: identifying the subject in need of amelioration of symptoms or treatment of the infectious diseases or disease conditions that trigger a widespread release of cytokines; and administering one or more pharmaceutical compositions comprising a therapeutically effective amount of a curcumin extract, curcuminoids or synthetic curcumin (S-curcumin) and derivatives thereof, or empty liposomes, dissolved or dispersed in a suitable aqueous or non-aqueous medium sufficient to reduce the level of cytokines in the host.

Abstract: The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.

Abstract: The present application is directed to a filter and methods of making the same. The filter includes a block of dielectric material with a top surface including a patterned region, a bottom surface, and side surfaces. The filter also includes a through-hole extending through the block from the top surface to the bottom surface. The through-hole is partially surrounded by the patterned region. The filter also includes a wall extending from the top surface, the wall having an inner surface, an outer surface, and a roof. The bottom surface, side surfaces, outer surface, and roof have a first coating including glass frit. The patterned region, through-hole and inner surface have a second coating including glass frit. The glass frit in the first coating is at least 0.5% greater than the glass frit in the second coating. The application is also directed to a system including a printed circuit board and a filter.

Abstract: The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.

Abstract: The application at least describes a tuning and measurement fixture. The fixture comprises a bottom plate including side surfaces, a top surface and a bottom surface. The bottom plate includes a window extending between the top and bottom surfaces. The window can expose a through-hole of a filter positioned in the fixture. In addition, the top surface of the filter includes a signal connection and a ground connection configured to communicate with the filter. The bottom surface of the filter includes an RF port configured to transmit electrical characteristics of the filter. A top plate of the filter includes a top and a bottom surface. The top plate is separated from the bottom plate by a predetermined height. The top plate includes a window extending between the top and bottom surfaces. The window exposes the through-hole of the filter held in the fixture. The application also describes a method of tuning and measuring a filter in a fixture.

Abstract: A thermal spray apparatus to apply coatings to external and internal surfaces in restricted areas is provided. The apparatus includes: a fuel input line; an oxidizing gas input line; coolant input and outlet; a combustion chamber that facilitates primary combustion; a diverging section that splits the primary combustion flow into two or more streams; an elbow section that redirects the combustion streams; a convergent/divergent nozzle; a convergence section that recombines the combustion streams into a single combustion stream within an injection zone of the convergent/divergent nozzle; and a feedstock injector for the injection of feedstock material for forming said coatings into said injection zone of the convergent/divergent nozzle; wherein the convergent/divergent nozzle has a nozzle throat downstream of the injection zone whereby in operation the injection pressure of the feedstock material upstream of the nozzle throat approximates the pressure of the combustion stream within the injection zone.

Abstract: The present application is directed to a filter and methods of making the same. The filter includes a block of dielectric material with a top surface including a patterned region, a bottom surface, and side surfaces. The filter also includes a through-hole extending through the block from the top surface to the bottom surface. The through-hole is partially surrounded by the patterned region, The filter also includes a wall extending from the top surface, the wall having an inner surface, an outer surface, and a roof. The bottom surface, side surfaces, outer surface, and roof have a first coating including glass frit. The patterned region, through-hole and inner surface have a second coating including glass frit. The glass frit in the first coating is at least 0.5% greater than the glass frit in the second coating. The application is also directed to a system including a printed circuit board and a filter.

Abstract: The present application is directed to a filter and methods of making the same. The filter includes a block of dielectric material with a top surface including a patterned region, a bottom surface, and side surfaces. The filter also includes a through-hole extending through the block from the top surface to the bottom surface. The through-hole is partially surrounded by the patterned region. The filter also includes a wall extending from the top surface, the wall having an inner surface, an outer surface, and a roof. The bottom surface, side surfaces, outer surface, and roof have a first coating of silver and glass frit. The patterned region, through-hole and inner surface have a second coating of silver and glass frit. The glass frit in the first coating is at least 0.5% greater than the glass frit in the second coating. The application is also directed to a system including a printed circuit board and a filter.

Abstract: The present invention includes compositions and methods for preventing one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by an active agent or a drug in a human or animal subject comprising: an amount of a lysophosphatidyl compound adapted for oral administration effective to reduce or prevent one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by the active agent or drug. Such compositions may further comprise a monoglyceride, a free fatty acid or a combination of the foregoing, including, e.g., a eutectic mixture.