Abstract: A tobacco smoking mixture including an ammonia-release compound adapted to be formed into a lit-end cigarette is provided. The ammonia-release compound is incorporated in or on tobacco cut filler in an amount effective to reduce the cytotoxicity, and/or selective smoke constituents of cigarette smoke. Exemplary ammonia-release compounds include ammonium acetate, ammonium hydroxide, hexammine cobalt (III) chloride, hexammine cobalt (III) acetate, and combinations thereof. The ammonia-release compounds can release ammonia at temperatures between about 60° C. and about 400° C. Ammonia-release compounds can be combined with additives, such as glycerine, cobalt acetate, copper (II) acetate, zinc acetate, other metal salts or combinations thereof, to further reduce the cytotoxicity of cigarette smoke.

Abstract: A process for manufacturing a smoking article having reduced generation of benzo[a]pyrene during smoking thereof comprises preparing a treated tobacco by contacting a tobacco material with an extraction solvent consisting essentially of methanol, ethanol, 1-propanol or 2-propanol; and incorporating the treated tobacco in a smoking article.

Abstract: A tobacco rod having reduced levels of at least one phenolic compound precursor selected from the group consisting of gentisic acid, 3,4-dihydroxybenzoic acid, chlorogenic acid, rutin, scopoletin, quinic acid, a quinic acid derivative, caffeic acid, inositol and lignin. The concentration in mainstream smoke of phenolic compounds such as phenol, hydroquinones (e.g., hydroquinone, methyl hydroquinone and 2,3-dimethyl hydroquinone), catechols (e.g., p-coumaryl quinic acid, feruloyl quinic acid and syringoyl quinic acid) and cresols (e.g., o-cresol, m-cresol and p-cresol) can be reduced by reducing the concentration in uncured (e.g., green) or cured tobacco of the phenolic compound precursors.