Abstract: The plurality of pieces of low density cellular material, such as foam plastics, form a core panel having opposite side surfaces and with adjacent pieces having opposing edge surfaces extending between the side surfaces. Sheets of flexible material, such as veils or mats or scrim, are adhesively attached to the side surfaces, and portions of one sheet extend between the opposing adjacent edge surfaces for limiting flexing of the panel. The pieces may be tapered, and portions of the one sheet may project between the edge surfaces either partially or fully to form double wall webs. The webs may have flanges adhesively attached to the other sheet on the opposite side. One sheet may also be stretchable in areas not adhesively attached to the pieces to provide for curving the panel from a planar position maintained by the sheet on the opposite side.

Abstract: Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.

Abstract: The plurality of pieces of low density cellular material, such as foam plastics, form a core panel having opposite side surfaces and with adjacent pieces having opposing edge surfaces extending between the side surfaces. Sheets of flexible material, such as veils or mats or scrim, are adhesively attached to the side surfaces, and portions of one sheet extend between the opposing adjacent edge surfaces for limiting flexing of the panel. The pieces may be tapered, and portions of the one sheet may project between the edge surfaces either partially or fully to form double wall webs. The webs may have flanges adhesively attached to the other sheet on the opposite side. One sheet may also be stretchable in areas not adhesively attached to the pieces to provide for curving the panel from a planar position maintained by the sheet on the opposite side.

Abstract: A fiber reinforced core panel is formed from strips of plastics foam helically wound with layers of rovings to form webs which may extend in a wave pattern or may intersect transverse webs. Hollow tubes may replace foam strips. Axial rovings cooperate with overlying helically wound rovings to form a beam or a column. Wound roving patterns may vary along strips for structural efficiency. Wound strips may alternate with spaced strips, and spacers between the strips enhance web buckling strength. Continuously wound rovings between spaced strips permit folding to form panels with reinforced edges. Continuously wound strips are helically wrapped to form annular structures, and composite panels may combine both thermoset and thermoplastic resins. Continuously wound strips or strip sections may be continuously fed either longitudinally or laterally into molding apparatus which may receive skin materials to form reinforced composite panels.

Abstract: A composite core panel has opposite side surfaces for receiving skins to form a composite sandwich panel. The core panel includes a plurality of spaced blocks of low density cellular material such as foam plastics and have opposite side surfaces forming the side surfaces of the core panel and opposite edge surfaces extending between the side surfaces. A plurality of parallel spaced elongated primary strips of structural cellular material such as balsa wood or engineered foam have a higher density and extend between the blocks, and the blocks have side surfaces adhesively attached to edge surfaces of the blocks. A plurality of parallel spaced secondary strips of structural high density cellular material such as balsa wood or engineered foam extend transversely to the primary strips and have end surfaces adhesively attached to the primary strips and side surfaces adhesively attached to the blocks.

Abstract: Adhesives particularly useful for industrial bottle labeling are provided. The adhesives comprise at least one starch component and at least one protein component (which is not gelatin or casein). The adhesive is also free of synthetic polymer. The label, along with the adhesive, can be easily removed from the bottle during the recycling process. In one embodiment, the starch component does not contain leguminous starch having an amylose content of 25% or more. In another embodiment, the adhesive comprises a crosslinking agent.

Abstract: A composite core panel is produced by arranging a plurality of foam strips in adjacent relation and advancing the strips with one or two flexible sheets of porous reinforcement material and adhesive between platens to form a panel. The sheet on one side of the strips is folded between adjacent strips to form double wall pleats which may project either partially or fully between the strips and may have folded end portions overlying the other side of the strips. The second sheet may also form double wall pleats between the strips and be connected to the pleats in the first sheet. The core panel may be cut to form reinforced strips which are connected by adhesive in various arrangements to form other core panels. A core panel may also be formed by wrapping each foam strip longitudinally with a strip of reinforcing material and connecting the strips with adhesive.

Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.

Abstract: The present invention relates to a melt processable copolyetheramide made by reacting (a) one or more segments of polyamide hard blocks derived from a lactam-terminated diisocyanate and a lactam monomer, and (b) one or more segments of polyether soft blocks derived from a polyether diol. The invention further provides for methods of making said copolyetheramide, including a continuous extruder method of production.

Abstract: This invention relates to methods, pharmaceutical compositions and kits useful in treating female sexual dysfunction and the use of an estrogen agonist/antagonist for the manufacture of a medicament for the treatment of female sexual dysfunction. The compositions are comprised of an estrogen agonist/antagonist as a first active ingredient and a cyclic guanosine 3?,5?-monophosphate elevator as a second active component and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration.

Abstract: Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.

Abstract: A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; Ra, Rb and Rc are independently an alkyl group or an aryl group; Rd is an alkyl group, an aryl group, an alkoxylalkyl group, —RiSiRaRbRc or a benzyl group, wherein Ri is an alkylene group; Re is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRgRh, wherein Rg and Rh are independently H, an alkyl group or an aryl group; R3 is (CH2)n where n is and integer in the range of 0 to 5, —CH2CH(CH3)—, —CH?CH—, —CH?C(CH3)—, or —C?C—; R4 ?wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, Rk1, Rk2, Rk3, Rk4 and Rk5 are independently H, CH3, or OR2a, and Rs1, Rs2, Rs3, and Rs4 are independently H or CH3, wherein R2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; and R5 is

Abstract: The plurality of pieces of low density cellular material, such as foam plastics, form a core panel having opposite side surfaces and with adjacent pieces having opposing edge surfaces extending between the side surfaces. Sheets of flexible material, such as veils or mats or scrim, are adhesively attached to the side surfaces, and portions of one sheet extend between the opposing adjacent edge surfaces for limiting flexing of the panel. The pieces may be tapered, and portions of the one sheet may project between the edge surfaces either partially or fully to form double wall webs. The webs may have flanges adhesively attached to the other sheet on the opposite side. One sheet may also be stretchable in areas not adhesively attached to the pieces to provide for curving the panel from a planar position maintained by the sheet on the opposite side.

Abstract: A composite core panel has opposite side surfaces for receiving skins to form a composite sandwich panel. The core panel includes a plurality of spaced blocks of low density cellular material such as foam plastics and have opposite side surfaces forming the side surfaces of the core panel and opposite edge surfaces extending between the side surfaces. A plurality of parallel spaced elongated primary strips of structural cellular material such as balsa wood or engineered foam have a higher density and extend between the blocks, and the blocks have side surfaces adhesively attached to edge surfaces of the blocks. A plurality of parallel spaced secondary strips of structural high density cellular material such as balsa wood or engineered foam extend transversely to the primary strips and have end surfaces adhesively attached to the primary strips and side surfaces adhesively attached to the blocks.

Abstract: A fiber reinforced core panel is formed from strips of plastics foam helically wound with layers of rovings to form webs which may extend in a wave pattern or may intersect transverse webs. Hollow tubes may replace foam strips. Axial rovings cooperate with overlying helically wound rovings to form a beam or a column. Wound roving patterns may vary along strips for structural efficiency. Wound strips may alternate with spaced strips, and spacers between the strips enhance web buckling strength. Continuously wound rovings between spaced strips permit folding to form panels with reinforced edges. Continuously wound strips are helically wrapped to form annular structures, and composite panels may combine both thermoset and thermoplastic resins. Continuously wound strips or strip sections may be continuously fed either longitudinally or laterally into molding apparatus which may receive skin materials to form reinforced composite panels.

Abstract: Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the ?-turn of beta amyloid (A?) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.

Abstract: This invention relates to methods and kits useful for improving or maintaining urogenital health using an estrogen agonist/antagonist. The methods of treatment are effective for improving or maintaining urogenital health while substantially reducing the concomitant liability of adverse effects associated with estrogen administration. This invention also relates to methods of assessing vaginal health.

Abstract: A method and apparatus are provided for attaching a safety cutting blade onto a substrate, such as a cardboard blank. A piece of cutting blade material is cut to length and fed to a forming station that bends the piece to form a safety cutting blade having a plurality of cutting teeth. The cutting blade is fed to a crimping station where the cutting blade is mated with a substrate and affixed with the substrate. A transport then conveys the combined cutting blade and substrate away from the crimping station.

Abstract: Non-invasive methods for detecting arterial disease in vivo include obtaining acoustic signals from a sensor held on an external body region proximate an artery. A complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals is generated. A predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease is provided. A predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease and thickening of arterial junctions is also provided. It is determined whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease.

Abstract: This invention relates to methods, pharmaceutical compositions and kits useful in treating female sexual dysfunction and the use of an estrogen agonist/antagonist for the manufacture of a medicament for the treatment of female sexual dysfunction. The compositions are comprised of an estrogen agonist/antagonist as a first active ingredient and a cyclic guanosine 3?,5?-monophosphate elevator as a second active component and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration.