Patents by Inventor W. Ernest Lyons

W. Ernest Lyons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stimulating nerve growth with immunophilins
    Patent number: 6080753
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: June 27, 2000
    Assignee: Johns Hopkins University School of Medicine
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder
  • Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
    Patent number: 5898029
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: April 27, 1999
    Assignee: The John Hopkins University
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder