Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.

Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of preparing such compounds are also disclosed, including the preparation and use of the compound tert-butyl (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate of formula (110) as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.

Abstract: Disclosed herein are compounds, pharmaceutical compositions, and related methods for the treatment of viral infection, including RNA viral infection in subjects. The compounds, pharmaceutical compositions, and methods can modulate the innate immune antiviral response in vertebrate cells, including activating the RIG-I pathway.

Abstract: The present invention relates to an apparatus that is part of a reusable fuel processing unit that allows the absorption of char contained within vapor that is leaving the reactor including a gear box, gearbox housing, support flange and seal, exhaust housing, exhaust port, connecting flange, screw top split housing, vertical steal housing, three augers with drive shafts on each auger contained within the steel housing, discharge flange, support ring, expansion cart, and cam followers.

Abstract: A system includes an object identification module, a tailgate position module, and a user interface device (UID) control module. The object identification module is configured to identify at least one of a bumper of a vehicle and a tailgate of the vehicle in an image captured by a camera mounted to the tailgate. The tailgate position module is configured to determine that the tailgate is closed when the bumper is identified in the image, and determine that the tailgate is open when at least one of: the tailgate is identified in the image; and the bumper is not identified in the image. The UID control module is configured to adjust operation of a user interface device based on whether the tailgate is open or closed.

Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.

Abstract: A method of monitoring an attachment between a towing vehicle and a towed vehicle includes determining that a first attachment element on the towed vehicle is not coupled to a second attachment element on the towing vehicle, receiving an indication that the towing vehicle is moving, and activating at least one of a towing vehicle brake system, a visual alert system, and an audible alert system.

Abstract: Fractionation, the process used by refineries to break down carbon chains of petroleum compounds so that the desired carbon compound can be achieved. This process typically involves high heat, distillation, re-boiling, and energy intensive cooling processes. This application discloses an invention that will condense vapor produced by a pyrolysis reactor. This system uses one standard cyclone; three cascading cyclones with internal cyclonic rotation fins that force incoming vapor to maintain a fixed amount of rotation regardless of the vapor's velocity, heat sinks that increase condensation, reversing fins that force gases to reverse direction inside the cyclone decreasing vapor velocity to increase heat loss; a main collection tank that allows for the controlling of the fuel flash point; a compact low temperature coil cooler that uses 100 percent of the cooling surface that allows for the production of higher quality fuel; and, bubblers/scrubbers that produce back pressure into the pyrolysis reactor.

Abstract: A system includes an object identification module, a tailgate position module, and a user interface device (UID) control module. The object identification module is configured to identify at least one of a bumper of a vehicle and a tailgate of the vehicle in an image captured by a camera mounted to the tailgate. The tailgate position module is configured to determine that the tailgate is closed when the bumper is identified in the image, and determine that the tailgate is open when at least one of: the tailgate is identified in the image; and the bumper is not identified in the image. The UID control module is configured to adjust operation of a user interface device based on whether the tailgate is open or closed.

Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of preparing such compounds are also disclosed, including the use of (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.

Abstract: The present invention relates to an apparatus that is part of a reusable fuel processing unit that allows the absorption of char contained within vapor that is leaving the reactor including a gear box, gearbox housing, support flange and seal, exhaust housing, exhaust port, connecting flange, screw top split housing, vertical steal housing, three augers with drive shafts on each auger contained within the steel housing, discharge flange, support ring, expansion cart, and cam followers.

Abstract: Disclosed herein are compounds, pharmaceutical compositions, and related methods for the treatment of viral infection, including RNA viral infection in subjects. The compounds, pharmaceutical compositions, and methods can modulate the innate immune antiviral response in vertebrate cells, including activating the RIG-I pathway.

Abstract: The invention provides seed and plants of the tomato variety designated Picus. The invention thus relates to the plants, seeds and tissue cultures of tomato variety Picus and to methods for producing a tomato plant produced by crossing a plant of tomato variety Picus with itself or with another tomato plant, such as a plant of another variety. The invention further relates to seeds and plants produced by such crossing, and also relates to parts of a plant of tomato variety Picus including the fruit and gametes of such plants. The invention also relates to tomato variety FDS 14-2081, and to seeds and plants produced by crossing a plant of tomato variety FDS 14-2081 with itself or another tomato plant. The present invention is also directed to tomato variety FDS 14-2090, and to seeds and plants produced by crossing a plant of tomato variety FDS 14-2090 with itself or another tomato plant.

Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

Abstract: Disclosed herein are compounds, pharmaceutical compositions, and related methods for the treatment of viral infection, including RNA viral infection in subjects. The compounds, pharmaceutical compositions, and methods can modulate the innate immune antiviral response in vertebrate cells, including activating the RIG-I pathway.

Abstract: Fractionation, the process used by refineries to break down carbon chains of petroleum compounds so that the desired carbon compound can be achieved. This process typically involves high heat, distillation, re-boiling, and energy intensive cooling processes. This application discloses an invention that will condense vapor produced by a pyrolysis reactor. This system uses one standard cyclone; three cascading cyclones with internal cyclonic rotation fins that force incoming vapor to maintain a fixed amount of rotation regardless of the vapor's velocity, heat sinks that increase condensation, reversing fins that force gases to reverse direction inside the cyclone decreasing vapor velocity to increase heat loss; a main collection tank that allows for the controlling of the fuel flash point; a compact low temperature coil cooler that uses 100 percent of the cooling surface that allows for the production of higher quality fuel; and, bubblers/scrubbers that produce back pressure into the pyrolysis reactor.

Abstract: The present invention relates to an apparatus that is part of a reusable fuel processing unit that allows the absorption of char contained within vapor that is leaving the reactor including a gear box, gearbox housing, support flange and seal, exhaust housing, exhaust port, connecting flange, screw top split housing, vertical steal housing, three augers with drive shafts on each auger contained within the steel housing, discharge flange, support ring, expansion cart, and cam followers.

Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

Abstract: A CO2 conversion system includes at least a first reactor including a gas mixing tube, a spark ignition system for generating sparks in the gas mixing tube coupled to a catalyst chamber having a catalyst therein coupled to a reaction chamber. Inlet tubes each with gas flow control valves are for injecting process gases including O2, H2 and CO2 into the gas mixing tube, wherein the process gases react in the reaction chamber in at least one chemical reaction to form reaction products including output gases including CH4 and reaction heat. A process controller utilizes at a process temperature setpoint or a criteria for an output gas to control a temperature in the catalyst chamber to maintain the process temperature setpoint or output gas criteria by adjusting gas flow control valves for changing the mass flow of at least one process gas to reduce a heat from the chemical reaction.

Abstract: Disclosed herein are compounds, pharmaceutical compositions, and related methods for the treatment of viral infection, including RNA viral infection in subjects. The compounds, pharmaceutical compositions, and methods can modulate the innate immune antiviral response in vertebrate cells, including activating the RIG-I pathway.