Patents by Inventor W. Fraser Symmans

W. Fraser Symmans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF EVALUATING RESPONSE TO CANCER THERAPY
    Publication number: 20150376710
    Abstract: A method of evaluating a cancer patient comprising evaluating gene expression levels in a patient sample, calculating a predictor score using the gene expression levels, and assessing the likelihood of a therapeutic outcome using the predictor score is disclosed.
    Type: Application
    Filed: February 27, 2015
    Publication date: December 31, 2015
    Inventors: Christos HATZIS, W. Fraser SYMMANS
  • INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES
    Publication number: 20150368721
    Abstract: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.
    Type: Application
    Filed: January 21, 2015
    Publication date: December 24, 2015
    Inventors: W. Fraser SYMMANS, Christos HATZIS, Lajos PUSZTAI
  • METHODS OF EVALUATING RESPONSE TO CANCER THERAPY
    Publication number: 20130084570
    Abstract: A method of evaluating a cancer patient comprising evaluating gene expression levels in a patient sample, calculating a predictor score using the gene expression levels, and assessing the likelihood of a therapeutic outcome using the predictor score is disclosed.
    Type: Application
    Filed: April 14, 2011
    Publication date: April 4, 2013
    Applicant: The Board of Regents of the University of Texas Sy
    Inventors: Christos Hatzis, W. Fraser Symmans
  • INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES
    Publication number: 20100311601
    Abstract: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.
    Type: Application
    Filed: May 3, 2010
    Publication date: December 9, 2010
    Applicants: Nuvera Biosciences, Inc., The Board of Regents of the University of Texas System
    Inventors: W. Fraser Symmans, Christos Hatzis, Lajos Pusztai
  • Method of measuring residual cancer and predicting patient survival
    Patent number: 7711494
    Abstract: Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: May 4, 2010
    Assignees: Board of Regents, The University of Texas System, Nuvera Biosciences, Inc.
    Inventors: Christos Hatzis, W. Fraser Symmans, Lajos Pusztai
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Publication number: 20100009358
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
    Type: Application
    Filed: December 18, 2008
    Publication date: January 14, 2010
    Applicants: Millennium Pharmaceuticals, Inc., Board of Regents, The University of Texas System
    Inventors: Mark D. Ayers, Jim Stec, Andrew Damokosh, Edwin Clark, Kenneth R. Hess, Gabriel N. Hortobagyi, Lajos Pusztai, W. Fraser Symmans, Robert C. Bast, JR.
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Patent number: 7504222
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: March 17, 2009
    Assignees: Millennium Pharmaceuticals, Inc., Board of Regents, The University of Texas
    Inventors: Mark D. Ayers, Jim Stec, Andrew Damokosh, Edwin Clark, Kenneth R. Hess, Gabriel N. Hortobagyi, Lajos Pusztai, W. Fraser Symmans, Robert C. Bast, Jr.
  • CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES
    Publication number: 20070134688
    Abstract: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
    Type: Application
    Filed: September 11, 2006
    Publication date: June 14, 2007
    Inventors: W. Fraser Symmans, Christos Hatzis, Keith Anderson, Lajos Pusztai
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Publication number: 20030219767
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
    Type: Application
    Filed: October 31, 2002
    Publication date: November 27, 2003
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., M.D. Anderson Cancer Center
    Inventors: Mark D. Ayers, Jim Stec, Andrew Damokosh, Edwin Clark, Kenneth R. Hess, Gabriel N. Hortobagyi, Lajos Pusztai, W. Fraser Symmans