Patents by Inventor W. H. Irwin McLean

W. H. Irwin McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANIMAL MODEL WITH A FILAGGRIN GENE PROMOTER
    Publication number: 20150342164
    Abstract: The present invention is based upon the generation of a nucleic acid construct which may be used to generate transgenic non-human animals. The construct exploits a filaggrin based promoter region which directs the expression of a reporter sequence operatively linked thereto. The present invention provides a nucleic acid, said nucleic acid encoding a filaggrin promoter element and a nucleic acid sequence operatively linked thereto.
    Type: Application
    Filed: December 19, 2013
    Publication date: December 3, 2015
    Inventors: W.H. Irwin McLean, Vikas Hedge, Deena M. Leslie Pedrioli, Sitheswaran Nainamalai, Paul A. Campbell, Frances J.D. Smith
  • Methods and compositions for treating pachyonychia congenita
    Patent number: 7723314
    Abstract: A method for treating pachyonychia congenita (PC) by identifying a genetic mutation contributing to PC, preparing a siRNA sequence that inhibits expression of the identified mutation, and administering the siRNA to a cell of a subject afflicted with PC. The siRNA treatment can include silencing of both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: May 25, 2010
    Assignee: Transderm, Inc.
    Inventors: Roger L. Kaspar, Robyn P. Hickerson, Frances J. D. Smith, W. H. Irwin McLean