Abstract: A method of operating an articulatable surgical instrument. The method includes providing a rotary drive motion to a rotary drive member of a surgical end effector and converting the rotary drive motion to an upper axial motion and a lower axial motion at locations that are distal to the articulation joint. The method further includes applying the upper axial motion to an upper portion of a firing member and applying the lower axial motion to a lower portion of the firing member such that the upper axial motion and lower axial motion drives the firing member distally through the surgical end effector from a starting position to an ending position.

Abstract: An acoustic panel for a gas turbine engine, includes a panel body, a panel-body cover, and a support bracket. The panel body is configured to dampen vibrations caused by the gas turbine engine. The forward support bracket is configured to mount the acoustic panel to portions of the gas turbine engine.

Abstract: A two-piece firearm projectile includes a jacket and a penetrator. The proximal end portion of the penetrator is received in and mates with a corresponding recess defined in the inside surface of the jacket. A three-piece projectile includes a jacket, a slug, and a penetrator. The slug and at least part of the penetrator are encased by the jacket, where the slug is positioned between the base of the jacket and the proximal end of the penetrator. The proximal end of the penetrator overlaps axially and mates with the distal end of the slug. In one example, a frustoconical end of the penetrator is received in and mates with a frustoconical recess in the distal end of the slug or the jacket as the case may be.

Abstract: In various embodiments, a tissue thickness compensator can comprise one or more capsules and/or pockets comprising at least one medicament therein. In at least one embodiment, staples can be fired through the tissue thickness compensator to rupture the capsules. In certain embodiments, a firing member, or knife, can be advanced through the tissue thickness compensator to rupture the capsules.

Abstract: A device for coupling a propulsor to a marine vessel. The device includes a mounting bracket configured for attachment to the marine vessel. A support frame has a carriage and is configured for the propulsor to be coupled thereto, where the carriage is configured to slidably engage with the mounting bracket into a fixed position. A member is manually engageable to prevent the carriage from sliding out of the fixed position. The propulsor is coupled to the marine vessel by sliding the carriage into the fixed position and engaging the member, where the propulsor is operable to propel the marine vessel in water when the carriage is in the fixed position, and where the propulsor is configured for decoupling from the marine vessel by disengaging the member and sliding the carriage out of engagement with the mounting bracket.

Abstract: A medical insertion device includes an introducer assembly, a needle, and a housing. The introducer assembly includes a dilator coaxially disposed in a sheath, the dilator removably engaged to the sheath in an insertion configuration. The needle is coaxially disposed in the dilator, the needle having a distal tip and a proximal end coupled to a needle hub. The housing may be removably engaged to the dilator. The needle hub is movably disposed in the housing between a first locked position, a second locked position, and a third locked position.

Abstract: A method for treating a patient using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The needle extends through the catheter such that a distal end of the needle extends distal of a distal end of the catheter. The guidewire is coupled to the thumbwheel such that rotation of the thumbwheel advances a distal end of the guidewire through a lumen of the needle. The method includes holding the catheter insertion device, inserting the distal end of the needle and catheter into a blood vessel, rotating the thumbwheel to advance the distal end of the guidewire out of the lumen of the needle into the blood vessel, moving the catheter over the guidewire in the blood vessel, and removing the needle and the guidewire from the catheter.

Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Abstract: Systems, devices, and methods are provided for generating NO and delivering NO in controlled amounts. A system for generating nitric oxide (NO) is provided, and in some embodiments can include a converter configured to convert a source material to a NO-containing gas, at least one controller configured to independently control a conversion of the source material to the NO-containing gas and a delivery of the NO-containing gas to an inspiratory pathway, and one or more sensors configured to communicate, to the at least one controller, information related to the conversion of the source material to the NO-containing gas.

Abstract: Architectures for production of nitric oxide (NO) include systems and methods for generating NO having one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing NO using a flow of the reactant gas through one or more plasma chambers; a controller configured to regulate the amount of nitric oxide in the product gas using one or more parameters as an input to the controller, one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which product gas flows; and a flow divider configured to divide a product gas flow from the plasma chamber into a first product gas flow to provide a variable flow to a patient inspiratory flow and a second product gas flow.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Abstract: Provided herein are fusion protein comprising: an effector domain comprising a catalytic domain of a deubiquitinase, or a functional fragment or functional variant thereof; and a targeting domain comprising a moiety that specifically binds a mitochondrial protein. Also provided herein are methods of using the fusion proteins to treat a disease, including genetic diseases.

Abstract: Provided herein are fusion protein comprising: an effector domain comprising a catalytic domain of a deubiquitinase, or a functional fragment or functional variant thereof; and a targeting domain comprising a moiety that specifically binds a cytosolic protein. Also provided herein are methods of using the fusion proteins to treat a disease, including genetic diseases.

Abstract: Provided herein are fusion protein comprising: an effector domain comprising a catalytic domain of a deubiquitinase, or a functional fragment or functional variant thereof; and a targeting domain comprising a moiety that specifically binds a nuclear protein. Also provided herein are methods of using the fusion proteins to treat a disease, including genetic diseases.

Abstract: Provided herein are fusion protein comprising: an effector domain comprising a catalytic domain of a deubiquitinase, or a functional fragment or functional variant thereof; and a targeting domain comprising a moiety that specifically binds a membrane protein. Also provided herein are methods of using the fusion proteins to treat a disease, including genetic diseases.

Abstract: This present invention relates to methods for improved assays to quantify the level of chromatin targets from biological samples. These assays can be used for the detection of global levels of epigenetic modifications (e.g., histone and DNA modifications), chromatin associated proteins, or chromatin associated ribonucleic acids (RNA). The invention further relates to assay kits that include the reagents needed to prepare biological samples and perform said improved chromatin assays.

Abstract: A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.