Abstract: Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.

Abstract: Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.

Abstract: A motorcycle where the rear wheel of the motorcycle is not only driven but the front wheel is also driven. Power for the motor of the motorcycle is transmitted to a power transmitting joint which includes an output shaft. The power transmitting joint is mounted directly below the steering stem and on the steering axis of the motorcycle. The power to the front wheel is supplied through a chain which connects between the steering assembly and the front wheel with the chain being movable in conjunction with the front wheel when the front wheel is steered and with suspension movement as when bumps are encountered.

Abstract: Methods of treating lung diseases comprising administering inducers of NAD(P)H:quinone oxidoreductase 1 (NQO1) are disclosed. Inducers of NQO1 include naphthoquinones such as ?-lapachone. Methods of predicting whether a subject with a lung disease will respond to treatment with a naphthoquinone are also described herein.

Abstract: A motorcycle where the rear wheel of the motorcycle is not only driven but the front wheel is also driven. Power from the motor of the motorcycle is transmitted to a power transmitting joint which includes an output shaft. The power transmitting joint is mounted directly below the steering stem and on the steering axis of the motorcycle. The power to the front wheel is supplied through a chain which connects between the steering assembly and the front wheel with the chain being movable in conjunction with the front wheel when the front wheel is steered and with suspension movement as when bumps are encountered.

Abstract: A motorcycle where the rear wheel of the motorcycle is not only driven but the front wheel is also driven. Power from the motor of the motorcycle is transmitted to a power transmitting joint which includes an output shaft. The power transmitting joint is mounted directly below the steering stem and on the steering axis of the motorcycle. The power to the front wheel is supplied through a chain which connects between the steering assembly and the front wheel with the chain being movable in conjunction with the front wheel when the front wheel is steered and with suspension movement as when bumps are encountered.

Abstract: It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. Also provided is a method of preventing or reducing airway hyperresponsiveness in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. The IaI inhibitor can be any compound that inhibits the expression or activity of IaI or a gene encoding an IaI polypeptide. In some embodiments, the IaI inhibitor is administered locally to the airway of the subject in need of treatment. For example, the inhibitor can be administered by aerosol delivery, such as by using an inhaler or nebulizer.

Abstract: A carrying case for electronic equipment, such as a portable computer, includes back, front, top, bottom and side walls defining an interior including a compartment for receiving electronic equipment defined between a wall surface and a floating panel of the carrying case. The floating panel is selectively movable linearly toward and away from the wall surface to adjust the size of the compartment in accordance with the size of the electronic equipment received therein. A securing mechanism within the interior resiliently biases the floating panel toward the wall surface and provides a shock or impact absorbing effect for the electronic equipment. The carrying case has a handle including first and second handle portions rotatable between an engaged position wherein the handle portions are in abutment and a disengaged position wherein the handle portions are separated from one another. The first and second handle portions are configured to automatically matingly engage one another when rotated into abutment.

Abstract: A collapsible hunting cart apparatus for collapsing into a storage position for easy carrying. The collapsible hunting cart apparatus includes a pair of elongate arms. A plurality of connector bars connects the elongate arms. Each of the connecting bars has pair of ends. Each of the ends of the plurality of connecting bars is coupled to one of the elongate arms. A pair of wheels has an operative position and a storage position. In the operative position each of the wheels is rotatably mounted to one of the elongate arms. Each of the wheels is releasably coupled to the elongate arms. A first bracket and a second bracket hold the wheels in a storage position. The first bracket is fixedly coupled to a generally central portion of one of the connector bars. The second bracket is fixedly coupled to a generally central portion of another of the connector bars.

Abstract: An integral reinforced resin grating structure having a plurality of load bars having a height dimension and a neutral axis and a plurality of cross bars integrally connected with said load bars. The cross bars may have a height less than the load bar height. The upper surface of the cross bars may be flush with the upper surface of the load bars. The lower surface of the cross bars may be located near or above the neutral axis of the load bars. The cross bars and load bars are reinforced with rovings placed along their respective longitudinal axis. The load bars have longitudinal rovings placed below the lower surface of the cross bars. Above the lower surface of the cross bars, the load bar rovings are interwoven with the cross bar rovings.For improved plastic reinforced grating structures having increased surface hardness and abrasion resistance, tabular alumina or other materials having a Mohs hardness of approximately 7 or higher may be added to the resin.

Abstract: A multifunctional power driven positioning tool system wherein a battery powered screw driven removable central unit may be fitted into equipment to function as a tool for prying apart objects, for lifting or lowering within adjustable calibrated distances, for powering a material handling unit and for use in a press frame for pressing and pulling bearings.

Abstract: An impact tool comprised of a light weight housing having a forward anvil and hammer compartment, a hollow handle, and a rear cradle to receive a 12 volt motor, its housing and wiring therefor, with the motor removably accessible by the removal of only two threaded bolts. A trigger operated on-off switch is mounted in the handle.

Abstract: Low or zero-phosphate spray-dried detergent powders containing less than 10% sodium silicate are structured with a combination of a succinic acid salt and a film-forming polymeric polycarboxylate. The preferred detergency builder is alkali metal aluminosilicate.

Abstract: The present invention pertains to a machine dishwashing or rinsing composition being substantially free from anionic synthetic detergents or fatty acid soaps, and having a very low or zero phosphate content, which comprises a nonionic detergent surfactant, a water-soluble calcium sequestering agent, a specific polymeric material and an alkaline detergent material, said composition having improved non-filming, non-spotting or non-streaking properties.

Abstract: An improved tilting pad journal bearing for supporting a rotatable shaft and having a plurality of pads hydrostatically supported within a carrier ring by an oil film that is hydrodynamically generated. The improvement includes a bearing pad having a hydrostatic cavity in the outer face of the pad and positioned so that the radial center line of the cavity is in the range of 0.degree. to 12.degree. downstream of the pad radial center line, with reference to the direction of the rotation of the shaft. An improved pad cam for each adjacent bearing pad is also shown. The pad cam is mounted to the carrier ring and has a pair of inclined faces which converge towards each other as the radially innermost portion of the pad cam is approached. Correspondingly, the opposed ends of each pad are generally arcuate to provide pad end surfaces that confront the inclined pad cam surfaces.