Patents by Inventor W. Jeffrey Howe

W. Jeffrey Howe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified BACE
    Patent number: 7273743
    Abstract: The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: September 25, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Kuo-Chen Chou, W. Jeffrey Howe
  • Modified BACE
    Patent number: 7244606
    Abstract: The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: July 17, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Kuo-Chen Chou, W. Jeffrey Howe
  • Modified BACE
    Publication number: 20040005691
    Abstract: The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.
    Type: Application
    Filed: February 21, 2003
    Publication date: January 8, 2004
    Inventors: Kuo-Chen Chou, W. Jeffrey Howe
  • Substituted tetronic acids useful for treating HIV and other retroviruses
    Patent number: 6060600
    Abstract: This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: May 9, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Robert A. Chruscial, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe
  • Substituted tetronic acids useful for treating HIV and other retroviruses
    Patent number: 5977169
    Abstract: This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by the formula below.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: November 2, 1999
    Inventors: Robert A. Chrusciel, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe, Gordon L. Bundy