Abstract: Various embodiments include a camera with folded optics and lens shifting capabilities. Some embodiments include voice coil motor (VCM) actuator arrangements to provide autofocus (AF) and/or optical image stabilization (OIS) movement. Some embodiments include suspension arrangements.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: An apparatus is provided for assisting in affixing a screen protector to a display of an electronic device. The apparatus includes a base including a platform configured to support the electronic device. The apparatus includes a lid configured to cover at least a portion of the base and the supported electronic device. The lid includes an aperture.

Abstract: A system and method used to deliver a valve delivery system carrying a valve to a target valve annulus in the heart includes a cable percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, transseptally through the heart, to a femoral artery. The valve delivery system device is passed over an end of the cable at the arterial side and is secured to the cable. The valve delivery system device is pushed in a distal direction while the venous end of the cable is pulled in the proximal direction, to advance the valve delivery system to the target valve annulus. A left ventricle redirector positionable on the cable from the venous end has a distal end actively steered during advancement and positioning of the valve delivery device, exerting forces that steer the distal nose of the valve delivery device as it moves towards the valve annulus.

Abstract: A system including a gearbox and a hydraulic machine connected by a working fluid circuit. The gearbox including a gearbox housing having first and second gearbox fluid passages integrated into the gearbox housing. The hydraulic machine including a case having first and second hydraulic machine fluid passages, the first and second hydraulic machine fluid passages being integrated into the case. A set of rotating elements enclosed within the case. The first gearbox fluid passage and the first hydraulic machine fluid passage align to form a feed passage to conduct fluid at a first pressure from a first source to the set of rotating elements. The second gearbox fluid passage and the second hydraulic machine fluid passage align to form a charge passage to conduct fluid at a second pressure from a second source to the set of rotating elements. The first pressure being less than the second pressure.

Abstract: Modular skid units are provided that are versatile and easily configurable for particular applications. In some examples, a modular design allows for many different combinations of modular components, such as seats, canine boxes, storage boxes, patient transport units, etc. In some examples, the modular and quick release nature of the system enables users to selectively remove and attach the modular components as needed for a given task, including the ability to quickly and easily change the modular components in the field to meet the specific needs of a mission or task. In some examples, the modular components include quick release locking mechanisms that include a set of locking elements for quickly and easily switching components.

Abstract: The present disclosure relates to compounds that are capable of upregulating sAPP? and/or stabilizing reticulon-3. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease).

Abstract: A tissue thickness compensator comprising a first compensation layer, a second compensation layer, and a pocket situated between the compensation layers can be positioned in the end effector of a surgical instrument. A fastener cartridge positioned in the end effector can comprise a fastener moveable between an initial position and a fired position. When the fastener is moved from the initial position to the fired position, the fastener can move through the pocket and can compress a portion of the tissue thickness compensator. A support can be positioned between the first and second compensation layers. When the fastener compresses the tissue thickness compensator, at least one of the support, first compensation layer and second compensation layer can be deformed. The tissue thickness compensator can also comprise a tab and/or a limiting plate to control deformation of the compensation layers and/or the support.

Abstract: Muconic acid is a molecule that can be converted into direct replacement chemicals for incumbent petrochemicals and performance-advantaged bioproducts. Disclosed herein are Pseudomonas putida KT2440 that are engineered to convert glucose and xylose, the primary carbohydrates in lignocellulosic hydrolysates, to muconic acid using a model-guided strategy to maximize the theoretical yield. Using adaptive laboratory evolution (ALE) and metabolic engineering in a strain engineered to express the D-xylose isomerase pathway, we demonstrated that mutations in the heterologous D-xylose:H+ symporter (XylE), increased expression of a major facilitator superfamily transporter (PP_2569), and overexpression of aroB encoding the native 3-dehydroquinate synthase, enable efficient muconic acid production from glucose and xylose simultaneously. Using the rationally engineered strain, we produced 33.7 g/L muconate at 0.18 g/L/h and a 46% molar yield (92% of the maximum theoretical yield).

Abstract: A system for assessing the characteristics of one or more geological formations that includes a programmable processing system configured receive at least one data stream including (1) a stream of well-pressure measurements, where each item of well-pressure measurement data corresponds to the pressure within the geological formation at a given time, (2) a stream of data associated with the flow of water and/or slurry into the geological formation at different times, and (3) a stream of data associated with the flow of sand into the geological formation at different times, where the programmable processing system is further configured to categorize fracturing events into different categories.

Abstract: The present disclosure relates to vehicle teleoperation and systems and methods for an autonomous-ready vehicle. As an example, the described aspects may provide a variety of functionality, including the use of a teleoperation assembly to provide a third-person perspective for vehicle teleoperation, vehicle width fit checking for a set of obstacles and an associated clearance, semi-autonomous clearance navigation, dynamic vehicle standoff adjustment according to a communication latency associated with teleoperation, vehicle contents change detection and notification generation, path navigation with increased granularity based on ground-engaging member paths, autonomous anchoring for increased traction, vehicle configuration according to a determined three-dimensional center of mass, automatic rocking for improved terrain traversal, audio-aware path generation and vehicle routing, and annunciation of vehicle modes to nearby individuals.

Abstract: Disclosed herein are methods and compositions that enable the production of branched-chain polyhydroxyalkanoates, branched-chain 3-hydroxyacids (BCHA) (PHA monomers), and branched-chain fatty acids (BCFA) in Pseudomonas putida KT2440. The branched-chain molecules enabled by this platform enable novel chemistries that are not accessible via the existing paradigm which is limited to straight-chain molecules. Further disclosed herein are methods and compositions for deciphering the mechanisms of bacterial fatty acid biosynthesis is crucial for both the engineering of bacterial hosts to produce fatty acid-derived molecules and the development of new antibiotics.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: A system and method for increasing the efficiency of an avalanche relay scheme is disclosed. The system and method include a plurality of networked nodes communicating in a slot and subslot scheme, with transmissions of a first signal from a first subslot relayed in subsequent subslots. The method and system include transmitting an initial transmission that includes the first signal, and then continuing to transmit at least one of a retransmitted portion of the first signal, or a transmission of an algorithmically related signal based on the first signal. The receiving node combines the first signal with the retransmitted portion of the first signal or the algorithmically related signal to determine if the initial transmission is valid. Upon a determination that the initial transmission is valid, the relay node retransmits the initial transmission in a future subslot.

Abstract: Methods and devices for using surgical devices with articulating end effectors are provided. Surgical devices with articulating end effectors can provide rotary driven pivoting of the end effector. In some embodiments, the device can include a handle, a first and a second tube extending from the handle, the second tube disposed within the first tube, and an end effector that includes a pair of distal jaws configured to move in response to rotation of the first tube about a longitudinal axis thereof and rotation of the second tube about a longitudinal axis thereof. The jaws can move in two different ways depending on whether the first and second tubes are rotating in a same direction as one another or in different ways than each other. The jaws can open/close and articulate using the same mechanical mechanism. The device can be powered, or the device can be non-powered.

Abstract: An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected.

Abstract: The present disclosure relates to a genetically modified microbial cell that includes a first genetic modification resulting in the expression of an exogenous vanillate demethylase, such that the microbial cell is capable of metabolizing an S-lignin decomposition product and producing 2-pyrone-4,6-dicarboxylate (PDC).

Abstract: A system and method for controlling a lighting system may be integrated into a lighting fixture or into a stand-alone device. A plurality of inputs defining one or more lighting parameters may be received. The inputs may include input signals characterized by at least two different control protocols. The input signals may be combined into an output signal characterized by a single control protocol, and the output signal used to control the lighting system.