Patents by Inventor W. Lee KRAUS

W. Lee KRAUS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants
    Patent number: 9926340
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 27, 2018
    Assignees: The Board of Regents of the University of Texas System, Biolog Life Science Institute Forshungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee Kraus, Bryan A. Gibson, Frank Schwede, Hening Lin
  • TSP1 AS A MARKER FOR CANCER
    Publication number: 20180052169
    Abstract: The present disclosure is directed to TSP1 and its coding RNA and cDNA as markers for cancer. Diagnostic methods and reagents for performing such assays also are described.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 22, 2018
    Inventors: W. Lee KRAUS, Shrikanth S. GADAD, Venkat S. MALLADI
  • ADP-ribose detection reagents
    Patent number: 9599606
    Abstract: The present disclosure described fusion proteins between ADP-ribose binding domains and antibody Fc domains. This new class of reagents has considerable value as detection agents in assays designed at examining the biology of ADP-ribose.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 21, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: W. Lee Kraus, Bryan A. Gibson
  • NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS
    Publication number: 20160299141
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 13, 2016
    Applicants: Biolog Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee KRAUS, Bryan A. GIBSON, Frank SCHWEDE, Hening LIN
  • ADP-RIBOSE DETECTION REAGENTS
    Publication number: 20150355172
    Abstract: The present disclosure described fusion proteins between ADP-ribose binding domains and antibody Fc domains. This new class of reagents has considerable value as detection agents in assays designed at examining the biology of ADP-ribose.
    Type: Application
    Filed: June 9, 2015
    Publication date: December 10, 2015
    Applicant: The Board of Regents of the University of Texas System
    Inventors: W. Lee KRAUS, Bryan A. GIBSON