Abstract: A folding wingtip aircraft includes a wing that includes a primary portion and a wingtip. The folding wingtip aircraft includes a folding wingtip system configured to rotate the wingtip relative to the primary portion. The folding wingtip aircraft also includes a flight control computer. The flight control computer is configured to, in response to a first determination that a wingtip position of the wingtip is not in a folded position when a second determination indicates that a last completed command by the folding wingtip system was a fold command, set error codes for the folding wingtip system. The flight control computer is also configured to change a setting to indicate that the folding wingtip aircraft is grounded based on the error codes.

Abstract: A method includes implementing, via an electronic controller of an aircraft, an extend command received by the electronic controller from a flight control computer to rotate a wingtip of a wing to a flight position. The method includes, in response to a first determination at the electronic controller that rotation of the wingtip stopped before the flight position during implementation of the extend command, sending a first notification signal to the flight control computer from the electronic controller to cause the aircraft to be grounded and to schedule maintenance of the aircraft. The first notification signal includes one or more first error codes. The first notification signal causes the maintenance to include wingtip-to-latch pin drop maintenance responsive to a determination of the electronic controller indicating that a first particular angle of the wingtip relative to a primary portion of the wing is in a latch pin interference range.

Abstract: A method for mixing, milling, and coating a plurality of constituents comprises placing the constituents in a container that includes a cylindrical inner surface; applying a first vibration to the container such that a motion of the vibration is parallel to a longitudinal axis of the container; and applying a second vibration to the container such that the motion of the vibration is not parallel to the longitudinal axis of the container.

Abstract: The present invention relates to a method for preparing an aqueous dispersion of opacifying pigment-binder hybrid particles that provides particle swelling and concomitant introduction of a binder layer without inhibition of polymerization. The composition prepared by the process of the present invention is useful for reducing the level of TiO2 in paints.

Abstract: Disclosed are systems and methods for an interactive digital interface. The disclosed systems and methods provide functionality for generating a user interface (UI) based on data collected respective to a plurality of regions within a location. The UI is configured with segments or partitions that correspond to real-world and/or digital activities among the plurality of regions. The disclosed systems and methods enable multiple devices to simultaneously display the UI, and interact among themselves via data sharing, data editing and/or collaborative interactions among the devices, such that the UI is updated, in real-time, to reflect the interactions among the devices.

Abstract: Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD19 antigen binding domain that specifically birnds to CD19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD19-specific CARs, and immune cells comprising these CD19-specific CARs.

Abstract: Disclosed are systems and methods that provide a novel framework for the real-time management and control of electronic/digital and/or physical activities performed in, around and/or in relation to a healthcare facility. The disclosed framework provides an interactive user interface (UI) that displays, as immersive and interactive interface cards, real-time digital data and content that corresponds to the digital and/or physical activities. The interactive interface cards are selectable, and configured with portal capabilities for the discovery of additional information, the creation of new forms of data, and the interaction with other users, entities, departments and other interactive capabilities in/around the facility. The disclosed framework enables a fully interactive, personalized and dynamic management platform for controlling operations of a facility while maintaining management control of those operations.

Abstract: Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD19 antigen binding domain that specifically binds to CD19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD19-specific CARs, and immune cells comprising these CD19-specific CARs.

Abstract: The present invention relates to a composition comprising an aqueous dispersion of acrylic polymer particles; paraffin wax; graphite particles; and extender particles. The composition is useful for making coatings with low water pickup for liquid applied sound damping applications.

Abstract: Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge far performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device.

Abstract: Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device.

Abstract: A method for mixing, milling, and coating a plurality of constituents comprises placing the constituents in a container that includes a cylindrical inner surface; applying a first vibration to the container such that a motion of the vibration is parallel to a longitudinal axis of the container; and applying a second vibration to the container such that the motion of the vibration is not parallel to the longitudinal axis of the container.

Abstract: The present invention relates to a waterborne composition comprising an aqueous dispersion of first and second multistage polymer particles, wherein each of the first and second polymer particles comprises a water-occluded core and a high Tg polymeric shell wherein the second multistage polymer particles further comprise a polymeric binder layer superposing the shell. The composition of the present invention is useful for reducing the load of TiO2 in paint formulations, while producing coatings with excellent hiding and scrub resistance.

Abstract: Provided herein are formulations and drug product processes that can improve cell viability and minimize waste of the manufactured formulated cells for a drug product.

Abstract: The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non Faradaic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid problems associated with ionic screening within the channel. At least one of the electrodes within the channel is coated with an insulating layer to prevent a Faradaic current from flowing in the channel. Under pulsed application of a unipolar voltage to the electrodes, charged analyte within the sample is moved towards one of the electrodes via a transient electrophoretic force.

Abstract: The present invention relates to a composition comprising an aqueous dispersion of multistage polymer particles comprising a first and a second phase, wherein the first phase comprises structural units of a carboxylic acid monomer or a salt thereof, and a nonionic ethylenically unsaturated monomer; and wherein the second phase comprises a first and second polymer, wherein the first phase or the second phase first polymer or both comprise structural units of a high Tg hydrophobic monomer; and wherein the second phase second polymer comprises at least 80 percent structural units of styrene. The high Tg hydrophobic monomer is defined as being one or more of the following monomers: cyclohexyl methacrylate, isobornyl methacrylate, 4-t-butyl methacrylate, t-butylstyrene, or n-butyl methacrylate. The multistage polymer particles are useful as opaque polymers, which are used in pigmented coating formulations to reduce the load of TiO2.

Abstract: Identification and monitoring of healthcare issues includes determining how to process input data based on at least one of identity of a user device that transmits the input data to the system and categorization of the input data. A new record is created in a database of healthcare issues in a healthcare facility where the user device is located when the input data is received. Anonymous reporting of issues is supported by storing an identifier of the user device that transmits the input data to the system, so that the anonymous reporter can be invited by a manager to join in an anonymous chat session. Recording of data during supervisor walkrounds is supported by setting up scheduled walkrounds with default labels to simplify input of identified healthcare issues, while allowing for custom labels to be entered when needed.

Abstract: Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the micro-fluidic device.

Abstract: Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the micro-fluidic device.

Abstract: A deployable fiber optic cable for pairing with a connector, the cable including a plurality of partially bonded ribbon fibers each being sized and configured to be rolled into a circular cross section; an elongate member forming a slotted core including a plurality of rounded slots for longitudinally surrounding the circular cross sections of a corresponding plurality of the plurality of partially bonded ribbon fibers; a plurality of rugged fiber tubes each located adjacent a corresponding one of the plurality of slots and wherein each of the plurality of rugged fiber tubes longitudinally surround a corresponding plurality of the plurality of partially bonded ribbon fibers; a plurality of water-blocking yarn members each surrounding a corresponding one of the plurality of rugged fiber tubes; a rugged outer jacket; and a yarn strength member located between the rugged outer jacket and the slotted core.