Abstract: This disclosure relates to a substrate comprising multiple layers which are designed to provide moisture absorption, non-adherence, and antimicrobial properties to a contact surface. The substrate is minimally comprised of (a) at least one skin contact layer of apertured hydrophobic polymeric film, (b) at least one layer of absorptive material that contains a reinforcement material, and (c) at least one layer of liquid impermeable film backing. The substrate may also include a layer of material that contains an antimicrobial agent. The substrate may be ideally suited for use in the medical field as an absorptive pad for end-uses such as wound care (e.g. burn care), surgery care, and incontinence care.