Patents by Inventor W. Michael Nichols

W. Michael Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dissolution of triprolidine hydrochloride
    Patent number: 6245785
    Abstract: The present invention is directed to pharmaceutical compositions containing triprolidine and an ionic additive that improves the measured availability of the triprolidine in the tablet, as indicated by standard USP assay for triprolidine in pharmaceutical compositions. The invention also provides a process for producing compositions having improved triprolidine availability and a process for improving the performance of a pharmaceutical composition in a dissolution assay measuring triprolidine availability. The ionic additive can be, for example, an alkali metal salt, such as sodium chloride or potassium chloride.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: June 12, 2001
    Assignee: Warner Lambert Company
    Inventors: Victor A. Cruz, W. Michael Nichols, Albert F. Sorg, George E. Tortarolo, William Bess, Neema Kulkarni
  • Denaturants for sympathomimetic amine salts
    Patent number: 6136864
    Abstract: A pharmaceutical composition has an acid salt of a sympathomimetic amine; and a denaturant of (i) at least one gum or viscosity modifier, and (ii) at least one surfactant, wherein the gum or viscosity modifier and the surfactant are present in amounts sufficient to have a denaturing effect on the sympathomimetic amine without significantly compromising the release of the sympathomimetic amine from the composition.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: October 24, 2000
    Assignee: Warner-Lambert Company
    Inventors: W. Michael Nichols, William Bess, Stanley Lech