Patents by Inventor W?odzimierz Zagórski-Ostoja

W?odzimierz Zagórski-Ostoja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA vaccine, method of inducing the immune response, method of immunisation, antibodies specifically recognising the H5 haemagglutinin of an influenza virus and use of the DNA vaccine
    Patent number: 9505806
    Abstract: The object of the invention is a DNA vaccine, method of inducing the immune response, antibodies specifically recognizing the haemagglutinin H5 of an influenza virus and application of the DNA vaccine. According to the invention, one or two-fold immunization of hens with DNA vaccine containing a cDNA encoding the modified H5 haemagglutinin HA protein, i.e. with the deletion of the cleavage site between HA subunits (this provides for greater safety of the vaccines). Moreover, the encoding region of the HA is modified in such a way that protein production in the bird cells should achieve maximal yield. The main modification is codon optimization for the hens and deletion of the site of proteolytic cleavage between subunits HA1 and HA2.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: November 29, 2016
    Assignee: INSTYTUT BIOCHEMII I BIOFIZYKI PAN
    Inventors: Agnieszka Sirko, Anna Góra-Sochacka, Włodzimierz Zagórski-Ostoja, Anna Stachyra, Róza Sawicka, Bogusław Szewczyk, Beata Gromadzka, Violetta Sączyńska, Katarzyna Florys, Zenon Minta, Krzysztof Śmietanka