Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: Multiple circuits in a computing device can share one or more conductive elements. The use of the conductive element can vary by circuit, such as an antenna radiator for a radio frequency (RF) circuit or an electrode for an electrocardiography (ECG) circuit. The circuitry sharing a conductive element can utilize signals obtained over different frequency ranges. Those ranges can be used to select decoupling circuitry, or elements, that can enable the respective circuits to obtain signals over a respective frequency range, excluding signals over one or more other frequency ranges corresponding to other circuitry sharing the circuit. Such an approach allows for concurrent independent operation of the circuitry sharing a conductive element.

Abstract: An apparatus includes a substrate; a group III-Nitride barrier layer; a source electrically coupled to the group III-Nitride barrier layer; a gate on the group III-Nitride barrier layer; a drain electrically coupled to the group III-Nitride barrier layer; a p-region being arranged at or below the group III-Nitride barrier layer; and a recovery enhancement circuit configured to reduce an impact of an overload received by the gate. Additionally, at least a portion of the p-region is arranged vertically below at least one of the following: the source, the gate, an area between the gate and the drain.

Abstract: Systems, devices, and methods for tracking one or more physiological metrics (e.g., heart rate, blood oxygen saturation, and the like) of a user are described. For example, one or more light sources and one or more light detectors may be positioned on a wearable device such that light can be emitted towards the user's skin and further such that light reflected back to the wearable device can be measured and used to generate values for the one or more physiological metrics.

Abstract: A damper seal for a gas turbine engine includes a damper body extending in a first direction between a leading edge portion and a trailing edge portion, extending in a second direction between first and second sidewalls, and extending in a third direction between a convex outer damper face and a concave inner damper face. The inner damper face establishes a damper pocket. The leading and trailing edge portions slope inwardly from opposite ends of the damper body to bound the damper pocket in the first direction. The first and second sidewalls extend from the leading edge portion to the trailing edge portion and slope inwardly from opposite sides of the damper body to bound the damper pocket in the second direction. The outer damper face is pre-formed according to a first predetermined geometry that substantially corresponds to a second predetermined geometry of a platform undersurface bounding a neck pocket of an airfoil. A method of damping for a gas turbine engine is also disclosed.

Abstract: A device configured to determine the location and magnitude of a touch on a surface of the device. The device includes a transparent touch sensor that is configured to detect a location of a touch on the transparent touch sensor. The device also includes a force-sensing structure disposed at the periphery of the transparent touch sensor. The force sensor includes an upper capacitive plate and a compressible element disposed on one side of the upper capacitive plate. The force sensor also includes a lower capacitive plate disposed on a side of the compressible element that is opposite the upper capacitive plate.

Abstract: Approaches to determining a sleep fitness score for a user are provided, such as may be based upon monitored breathing disturbances of a user. The system receives user state data generated over a time period by a combination of sensors provided via a wearable tracker associated with the user. A system can use this information to calculate a sleep fitness score, breathing disturbance score, or other such value. The system can classify every minute within the time period as either normal or atypical, for example, and may provide such information for presentation to the user.

Abstract: An aspect of the disclosure pertains to a blood pressure measurement device and methods of controlling an inflation rate in a blood pressure measurement. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pressure sensor of the blood pressure measurement device is configured to obtain blood pressure measurements, and a pump of the blood pressure measurement device is configured to inflate the inflatable bladder and control an inflation rate by controlling at least one of a duty cycle, a voltage, or a drive frequency.

Abstract: A damper seal for a gas turbine engine includes a damper body extending in a first direction between a leading edge portion and a trailing edge portion, extending in a second direction between first and second sidewalls, and extending in a third direction between a convex outer damper face and a concave inner damper face. The inner damper face establishes a damper pocket. The leading and trailing edge portions slope inwardly from opposite ends of the damper body to bound the damper pocket in the first direction. The first and second sidewalls extend from the leading edge portion to the trailing edge portion and slope inwardly from opposite sides of the damper body to bound the damper pocket in the second direction. The outer damper face is pre-formed according to a first predetermined geometry that substantially corresponds to a second predetermined geometry of a platform undersurface bounding a neck pocket of an airfoil. A method of damping for a gas turbine engine is also disclosed.

Abstract: Approaches to determining a sleep fitness score for a user are provided, such as may be based upon monitored breathing disturbances of a user. The system receives user state data generated over a time period by a combination of sensors provided via a wearable tracker associated with the user. A system can use this information to calculate a sleep fitness score, breathing disturbance score, or other such value. The system can classify every minute within the time period as either normal or atypical, for example, and may provide such information for presentation to the user.

Abstract: Multiple circuits in a computing device can share one or more conductive elements. The use of the conductive element can vary by circuit, such as an antenna radiator for a radio frequency (RF) circuit or an electrode for an electrocardiography (ECG) circuit. The circuitry sharing a conductive element can utilize signals obtained over different frequency ranges. Those ranges can be used to select decoupling circuitry, or elements, that can enable the respective circuits to obtain signals over a respective frequency range, excluding signals over one or more other frequency ranges corresponding to other circuitry sharing the circuit. Such an approach allows for concurrent independent operation of the circuitry sharing a conductive element.

Abstract: A manually powered treadmill includes a frame; a first rotatable element coupled to the frame; a second rotatable element coupled to the frame; a plurality of bearings coupled to the frame; a running belt at least partly supported by the plurality of bearings, where at least a portion of the running belt defines a curved running surface; and a safety device coupled to at least one of the first rotatable element and the second rotatable element. The safety device is structured to substantially prevent rotation of the at least one of the first rotatable element and the second rotatable element in a first rotational direction and permit rotation of the at least one of the first rotatable element and the second rotatable element in a second rotational direction opposite the first rotational direction.

Abstract: In one embodiment, a data processing method comprises obtaining one or more first photoplethysmography (PPG) signals based on one or more first light sources that are configured to emit light having a first light wavelength corresponding to a green light wavelength; obtaining one or more second PPG signals based on one or more second light sources that are configured to emit light having a second light wavelength corresponding to a red light wavelength, one or more of the first light sources and one or more of the second light sources being co-located; generating an estimated heart rate value based on one or more of the first PPG signals and the second PPG signals; and causing the estimated heart rate value to be displayed via a user interface on a client device.

Abstract: A manually powered treadmill includes a frame; a first rotatable element coupled to the frame; a second rotatable element coupled to the frame; a plurality of bearings coupled to the frame; a running belt at least partly supported by the plurality of bearings, where at least a portion of the running belt defines a curved running surface; and a safety device coupled to at least one of the first rotatable element and the second rotatable element. The safety device is structured to substantially prevent rotation of the at least one of the first rotatable element and the second rotatable element in a first rotational direction and permit rotation of the at least one of the first rotatable element and the second rotatable element in a second rotational direction opposite the first rotational direction.

Abstract: An aspect of the disclosure pertains to a blood pressure measurement device and methods of controlling an inflation rate in a blood pressure measurement. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pressure sensor of the blood pressure measurement device is configured to obtain blood pressure measurements, and a pump of the blood pressure measurement device is configured to inflate the inflatable bladder and control an inflation rate by controlling at least one of a duty cycle, a voltage, or a drive frequency.

Abstract: An enclosure is disclosed for transporting articles upon a satellite. The enclosure is composed of a plurality of interconnected walls coupled via elongated edge connecting members to define an internal space shaped and dimensioned for receiving an article to be transported upon a satellite. The walls are honeycombed aluminum sheets or solid aluminum panels and the edge connecting members are lightweight high strength members shaped and dimensioned for secure attachment to the walls without the use of mechanical coupling members.

Abstract: Multiple circuits in a computing device can share one or more conductive elements. The use of the conductive element can vary by circuit, such as an antenna radiator for a radio frequency (RF) circuit or an electrode for an electrocardiography (ECG) circuit. The circuitry sharing a conductive element can utilize signals obtained over different frequency ranges. Those ranges can be used to select decoupling circuitry, or elements, that can enable the respective circuits to obtain signals over a respective frequency range, excluding signals over one or more other frequency ranges corresponding to other circuitry sharing the circuit. Such an approach allows for concurrent independent operation of the circuitry sharing a conductive element.

Abstract: An apparatus includes a substrate; a group III-Nitride barrier layer; a source electrically coupled to the group III-Nitride barrier layer; a gate on the group III-Nitride barrier layer; a drain electrically coupled to the group III-Nitride barrier layer; a p-region being arranged at or below the group III-Nitride barrier layer; and a recovery enhancement circuit configured to reduce an impact of an overload received by the gate. Additionally, at least a portion of the p-region is arranged vertically below at least one of the following: the source, the gate, an area between the gate and the drain.

Abstract: An enclosure is disclosed for transporting articles upon a satellite. The enclosure is composed of a plurality of interconnected walls coupled via elongated edge connecting members to define an internal space shaped and dimensioned for receiving an article to be transported upon a satellite. The walls are honeycombed aluminum sheets or solid aluminum panels and the edge connecting members are lightweight high strength members shaped and dimensioned for secure attachment to the walls without the use of mechanical coupling members.

Abstract: A treadmill includes a frame; a rotatable element coupled to the frame; a running belt at least partially supported by the rotatable element; and, a first element and a second element, both of which are coupled to the running belt. The running belt includes a running surface, at least a portion of which is curved. Further, one of the first and second elements and the running belt freely rotate in a first direction of rotation relative to the frame. However, in a second direction of rotation, opposite the first direction of rotation, the one of the first and second elements is substantially prevented from rotation relative to the frame to substantially prevent or resist rotation of the running belt relative to the frame.