Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: A rotary to linear actuator, comprises a drive crankarm that rotates in a first axis of rotation; a first and second gearset connected to the drive crankarm through a second crankarm; and a piston captured between the first gearset and the second gear set, wherein the first and second gearsets rotate a crankarm connected to one end of the piston, wherein the piston is caused to move linearly upon rotation of the crankarm.

Abstract: A rotary to linear actuator, comprises a drive crankarm that rotates in a first axis of rotation; a first and second gearset connected to the drive crankarm through a second crankarm; and a piston captured between the first gearset and the second gear set, wherein the first and second gearsets rotate a crankarm connected to one end of the piston, wherein the piston is caused to move linearly upon rotation of the crankarm.

Abstract: Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

Abstract: Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

Abstract: Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

Abstract: The invention provides a nutritional supplement which includes phytosterol to facilitate reduction of cholesterol. The nutritional supplement may be a swallowable tablet, chewable tablet, sachet, capsule or suspension. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized swallowable tablet and a method for reducing blood cholesterol in humans.

Abstract: The invention provides a nutritional supplement which includes micronutrients to facilitate reduction of cholesterol, and/or reduction of homocystein and/or reduction of low-density lipoprotein-cholesterol (LDL-C) oxidation in humans. In one embodiment the supplement is a multi-vitamin, a mineral supplement which includes at least one component known to reduce cholesterol. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized tablet and a method for reducing blood cholesterol in humans.

Abstract: The invention provides a nutritional supplement which includes micronutrients to facilitate reduction of cholesterol, and/or reduction of homocystein and/or reduction of low-density lipoprotein-cholesterol (LDL-C) oxidation in humans. In one embodiment the supplement is a multi-vitamin, a mineral supplement which includes at least one component known to reduce cholesterol. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized tablet and a method for reducing blood cholesterol in humans.

Abstract: The chimeric polypeptide R3(B?23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

Abstract: The invention provides a nutritional supplement which includes micronutrients to facilitate reduction of cholesterol, and/or reduction of homocystein and/or reduction of low-density lipoprotein-cholesterol (LDL-C) oxidation in humans. In one embodiment the supplement is a multi-vitamin, a mineral supplement which includes at least one component known to reduce cholesterol. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized tablet and a method for reducing blood cholesterol in humans.

Abstract: A vehicle joint assembly is provided comprising an outer race having an outer surface and an inner surface. A pair of opposed slot tracks are formed in the inner cup surface and each comprise a track top wall and two track sidewalls. A barshaft is in communication with a bipod element comprised of a body portion and two opposed peg portions. Each of the two opposed peg portions comprises two opposed curved engagement surfaces engaging one of the track sidewalls. The bipod element is positioned within the outer race such that each of the opposed peg portions resides in one of the opposed slot tracks. The bipod element is capable of being positioned in a variety of angles within the slot tracks and is capable of plunging within the slot tracks.

Abstract: An embodiment of a constant velocity joint includes a first rotational member having a generally cylindrical surface. The generally cylindrical surface is defined, at least in part, by a groove portion. The constant velocity joint further includes a grease cover selectively positioned adjacent the first rotational member. An edge portion of the grease cover is positioned within the groove to at least partially retain the grease cover in a desired position.

Abstract: Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.

Abstract: The chimeric polypeptide R3(B?23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

Abstract: A vehicle joint assembly is provided comprising an outer race having an outer surface and an inner surface. A pair of opposed slot tracks are formed in the inner cup surface and each comprise a track top wall and two track sidewalls. A barshaft is in communication with a bipod element comprised of a body portion and two opposed peg portions. Each of the two opposed peg portions comprises two opposed curved engagement surfaces engaging one of the track sidewalls. The bipod element is positioned within the outer race such that each of the opposed peg portions resides in one of the opposed slot tracks. The bipod element is capable of being positioned in a variety of angles within the slot tracks and is capable of plunging within the slot tracks.

Abstract: The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of the present invention. Exemplary methods of the present invention utilize PFSK-1 cells to produce non-recombinant human orexin-2 receptor protein.

Abstract: An embodiment of a constant velocity joint includes a first rotational member having a generally cylindrical surface. The generally cylindrical surface is defined, at least in part, by a groove portion. The constant velocity joint further includes a grease cover selectively positioned adjacent the first rotational member. An edge portion of the grease cover is positioned within the groove to at least partially retain the grease cover in a desired position.

Abstract: An improved boot for use in sealing a constant velocity joint and ball spline joint assembly includes a plurality of articulating convolutes, a grease catching member, and a first stabilizing member adapted to ride above an inner race of the ball spline joint to join the plurality of articulating convolutes and the grease catching member and provide stability at high speed. The boot further includes a plurality of plunging convolutes and a second stabilizing member adapted to ride above an outer race of the ball spline joint to join the plurality of plunging convolutes and the grease catching member and provide additional stability.

Abstract: A constant velocity joint is provided that includes an outer race having a bore with an inner surface, a cage arranged within the bore of the outer race, an inner race having an outer surface, a plurality of balls arranged within the cage, and a shaft connected to the inner race. The cage, outer race, inner race, and balls interrelate to center and support the cage. The cage remains in a non-supporting state with the outer race and the inner race through a no angle and a high angle position of the shaft.