Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, which provides for targeting to, and uptake by, tissues and cells of the CNS via administration to a subarachnoid space, e.g., the cisterna magna. Another aspect of the invention relates to a method of gene silencing in tissues and cells of the CNS, that includes administering to the subarachnoid space of a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: A power tool with a combined printed circuit board (PCB) that reduces internal wiring of the power tool and provides a large amount of air flow to internal components. In some instances, the combined PCB has a surfboard shape and includes a motor control unit and power switching elements (Field Effect Transistors or FETs). The combined surfboard PCB is located above the trigger, but below the motor and drive mechanism. In other instances, the combined PCB has a doughnut shape and is located coaxially with a motor shaft. The combined PCB may be positioned between a doughnut-shaped control PCB and the motor.

Abstract: A data logger device for a power tool including a housing, a power tool interface provided at the top of the housing and configured to be received in a corresponding interface of the power tool, and a battery pack interface provided at the bottom of the housing and configured to receive a corresponding interface of a battery pack providing operating power to the power tool. The data logger also includes a tool terminal block, a battery terminal block provided, and bus bars connecting the tool terminal block to the battery terminal block to provide pass through power from the battery pack to the power tool. The data logger is configured to obtain data related to power tool operation, and export, using a transceiver, the data to a user device.

Abstract: A power tool with a combined printed circuit board (PCB) that reduces internal wiring of the power tool and provides a large amount of air flow to internal components. In some instances, the combined PCB has a surfboard shape and includes a motor control unit and power switching elements (Field Effect Transistors or FETs). The combined surfboard PCB is located above the trigger, but below the motor and drive mechanism. In other instances, the combined PCB has a doughnut shape and is located coaxially with a motor shaft. The combined PCB may be positioned between a doughnut-shaped control PCB and the motor.

Abstract: A fishing pole handle including an elongate first portion that extends along a first axis and is configured to engage a foot of an attachable reel assembly, an elongate second portion that extends along a second axis substantially perpendicular to the first axis, the first and second portions constrained against relative movement in directions along the first axis, and a selectively engageable coupling mechanism between the first and second portions. The first and second portions are rotatably retainable to each other about the first axis through engagement of the coupling mechanism, and are relatively moveable about the first axis through disengagement of said coupling mechanism. Relative to each other about the first axis, the first and second portions are selectively moveable between alternative ones of a plurality of different radial orientations or rotatably retained to each other in one of the plurality of different radial orientations.

Abstract: A power tool with a combined printed circuit board (PCB) that reduces internal wiring of the power tool and provides a large amount of air flow to internal components. In some instances, the combined PCB has a surfboard shape and includes a motor control unit and power switching elements (Field Effect Transistors or FETs). The combined surfboard PCB is located above the trigger, but below the motor and drive mechanism. In other instances, the combined PCB has a doughnut shape and is located coaxially with a motor shaft. The combined PCB may be positioned between a doughnut-shaped control PCB and the motor.

Abstract: A miter saw includes a base assembly and a saw unit pivotably coupled to the base assembly. The saw unit includes a saw arm, a brushless motor supported by the saw arm, and power electronics positioned outside the motor for supplying power to the motor. The power electronics are coupled to a structural component of the miter saw to utilize the entire mass of the structural component as a heat sink to dissipate heat generated by the power electronics.

Abstract: A data logger device for a power tool including a housing, a power tool interface provided at the top of the housing and configured to be received in a corresponding interface of the power tool, and a battery pack interface provided at the bottom of the housing and configured to receive a corresponding interface of a battery pack providing operating power to the power tool. The data logger also includes a tool terminal block, a battery terminal block provided, and bus bars connecting the tool terminal block to the battery terminal block to provide pass through power from the battery pack to the power tool. The data logger is configured to obtain data related to power tool operation, and export, using a transceiver, the data to a user device.

Abstract: A power tool with a combined printed circuit board (PCB) that reduces internal wiring of the power tool and provides a large amount of air flow to internal components. In some instances, the combined PCB has a surfboard shape and includes a motor control unit and power switching elements (Field Effect Transistors or FETs). The combined surfboard PCB is located above the trigger, but below the motor and drive mechanism. In other instances, the combined PCB has a doughnut shape and is located coaxially with a motor shaft. The combined PCB may be positioned between a doughnut-shaped control PCB and the motor.

Abstract: A power tool with a combined printed circuit board (PCB) that reduces internal wiring of the power tool and provides a large amount of air flow to internal components. In some instances, the combined PCB has a surfboard shape and includes a motor control unit and power switching elements (Field Effect Transistors or FETs). The combined surfboard PCB is located above the trigger, but below the motor and drive mechanism. In other instances, the combined PCB has a doughnut shape and is located coaxially with a motor shaft. The combined PCB may be positioned between a doughnut-shaped control PCB and the motor.

Abstract: A lid for the receiver vessel an centrally disposed intake opening and a plurality of outlet openings located on diametrically opposite sides of the intake opening, a non-perforated pipe of finite length connected to the intake opening and extending a finite distance that is at a minimum 2.5 times the diameter of the non-perforated pipe into the receiver vessel, the relationship of the diameter of the non-perforated pipe and the inside diameter of the receiver vessel which defines an air space therebetween being configured to a ratio that is equal to or greater than 1:2.5 to thereby cause the gas/air flow through the air space toward the plural outlet openings to be substantially uniform and substantially less than a pick-up velocity of the particulate so as to cause the particulate to become separated from the air flow.

Abstract: Controlled-release formulations providing a “pulsed” plasma profile of a sedative-hypnotic compounds having a particularly short half-life are provided. The formulation contains a sedative-hypnotic compound or precursor thereof that is metabolized to generate a sedative-hypnotic compound in vivo, wherein the compound has a mean plasma half life ranging from 0.1 to 2 hours; and at least one release retardant such that, following administration of the formulation to a patient, the patient has specified pulsed plasma profile for the sedative-hypnotic compound as disclosed herein. In a preferred embodiment, the sedative-hypnotic compound is NBI-34060.

Abstract: A vacuum receiver for separating particles entrained in a gas-particle stream and for allowing a gas stream to exit from the vacuum receiver to an exhaust blower while simultaneously allowing the particles to remain in a particle receiving vessel having an open top. A cover is provided which has a top wall with a perimeter thereof resting on a surface of the receiving vessel encircling the open top. The cover has two openings therethrough, the first opening being oriented directly above the particle receiving vessel and a second opening being oriented on an axis that is wholly outside a peripheral boundary of the particle receiving vessel. The cover further includes a structure defining a passageway extending from the particle receiving vessel to the aforesaid second opening. A reciprocal valve member is mounted in the passageway and a drive motor is provided therefor which is mounted on an exterior part of the passageway to facilitate easy access thereto.

Abstract: A vacuum receiver for use in a pneumatic vacuum conveying system having a lid which gas-tightly closes a particle storage vessel. The lid has two apertures therein allowing a gas-particle stream to enter the interior of the vessel and a gas stream to exit the vessel. An upstanding hollow inlet housing is gas-tightly secured on an exterior surface of the lid communicating with one of the apertures. An inlet port is provided in one side of the inlet housing. The gas-particle stream enters the inlet port with sufficient velocity so that the particles strike the inlet housing opposite the inlet port to decelerate the particles. The particles fall through the one aperture and are stored in the vessel. The gas stream also enters the vessel through the one aperture and exits through the other aperture into an upstanding hollow outlet housing. The gas stream exits the outlet housing via an outlet port in the outlet housing.

Abstract: A pneumatic material handling system for conveying dry, solid particulate product from one of at least two separate upstanding dry, solid particulate product supply containers to at least one desired destination. At least two identically constructed valves are connected into the conduit system intermediate the supply containers and the desired destination. Each of the two valves includes a base plate having at least first and second separate through passageways extending therethrough and a movable plate slidably mounted on the base plate and movable between first and second positions relative to the base plate. The movable plate has a third through passageway extending therethrough and being axially aligned with the first through passageway in the first position of the movable plate and with the second through passageway in the second position of the movable plate. A drive mechanism is provided for moving the movable plate between the first and second positions.

Abstract: A device for metering and entraining a measured quantity of a dry, powdered and/or granular product with a gas stream moving in a conduit system. The device includes a hollow housing having a gas inlet opening and a gas and product outlet opening to and from, respectively, the interior of the housing connected to the conduit system so that a gas stream enters and exits the housing in the conduit system. Inlet structure of an appropriate size at the gas inlet opening causes the gas stream to move between the inlet opening and the outlet opening through the interior of the housing at a sufficient velocity to pick up and entrain product in the interior of the housing in the gas stream. Product is allowed to enter the housing through a product receiving opening from a product supply container to facilitate a supply of product to the interior of the housing.

Abstract: A device for metering and entraining a measured quantity of a dry, powdered and/or granular product with a gas stream moving in a conduit system. The device includes a hollow housing having a gas inlet opening and a gas and product outlet opening to and from, respectively, the interior of the housing connected to the conduit system so that a gas stream enters and exits the housing in the conduit system. Inlet structure of an appropriate size at the gas inlet opening causes the gas stream to move between the inlet opening and the outlet opening through the interior of the housing at a sufficient velocity to pick up and entrain product in the interior of the housing in the gas stream. Product is allowed to enter the housing through a product receiving opening from a product supply container to facilitate a supply of product to the interior of the housing.

Abstract: An improved air drying process for a paper machine is disclosed whereby air is impinged directly onto a paper web between top and bottom dryers on an open paper draw. This provides additional drying and machine speed increase due to improved controlling of sheet flutter and improved drying via direct air impingement onto the sheet for all paper grades. The structure provides a radial jet reattachment nozzle to blow air onto the sheet while the paper web is not in contact with either cylinder surface and the fabric or felt. The nozzle stabilizes and supports the sheet to prevent sheet flutter and bulging.

Abstract: A fiber optic sensor array includes a row of transmitting optical fibers, with a column of detecting optical fibers overlapping the transmitting fibers. A planar compliant spacer separates the transmitting fibers from the detecting fibers, so that a sensor element is defined at each location where a detecting fiber overlaps a transmitting fiber. The surfaces of each transmitting fiber and each receiving fiber are modified at the location of each sensor element to increase the optical coupling between the transmitting fiber and the receiving fiber at that element. The spacer in the array includes an opening between the transmitting fiber and the detecting fiber at the location of each sensor element. A support surface is affixed to the detecting fibers opposite the compliant spacer and a protective cover layer is affixed to the transmitting fibers opposite the compliant spacer.

Abstract: A unifelt system for drying paper includes banks of upper and lower drying cylinders around which the paper is conveyed in contact with a support sheet. At least one suction nozzle is provided at the pocket formed at the upstreammost lower cylinder and the support sheet to prevent air from being trapped between the paper and the support sheet for minimizing bulging which might otherwise occur.