Patents by Inventor Waan-Jeng Nir

Waan-Jeng Nir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High efficiency gene trap selection of regulated genetic loci
    Patent number: 5922601
    Abstract: A gene trap construct for identification of genes whose activity is regulated upon a cellular transition event which comprises in downstream sequence (i) a cassette having a functional splice acceptor, a translation stop sequence and an internal ribosome entry site and (ii) a promoterless protein coding sequence encoding at least one polypeptide providing positive and negative selection traits. A method for identification of genes whose activity is regulated upon a cellular transition event by introducing the gene trap construct into a cell and observing expression of the positive and/or negative selection traits before and after the transition event.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: July 13, 1999
    Assignee: BioTransplant, Inc.
    Inventors: Manfred Baetscher, Waan-Jeng Nir