Patents by Inventor Waander Laurens Van Heerde

Waander Laurens Van Heerde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel chemiluminescent substrates for Factor Xa
    Publication number: 20210371461
    Abstract: The present invention relates to chemiluminescent substrates for blood clotting enzyme Factor Xa. The substrates are particularly useful for assaying coagulation factors and for quantifying an anticoagulant in a sample.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 2, 2021
    Applicant: Enzyre B.V.
    Inventors: Waander Laurens van Heerde, Mark van Geffen, Danique Steeghs
  • Chemiluminescence-based haemostasis assay
    Patent number: 10465230
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: November 5, 2019
    Assignee: STICHTING KATHOLIEKE UNIVERSITEIT
    Inventors: Waander Laurens Van Heerde, Richard Hendrik Blaauw
  • CHEMILUMINESCENCE-BASED HAEMOSTASIS ASSAY
    Publication number: 20180208963
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Application
    Filed: December 18, 2017
    Publication date: July 26, 2018
    Inventors: Waander Laurens Van Heerde, Richard Hendrik Blaauw
  • Chemiluminescence-based haemostasis assay
    Patent number: 9856510
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: January 2, 2018
    Assignees: Stichting Katholieke Universiteit, Chiralix B.V.
    Inventors: Waander Laurens van Heerde, Richard Hendrik Blaauw
  • Hemostasis assay
    Patent number: 8809006
    Abstract: Provided is a hemostasis assay comprising a reaction mixture comprising a blood product to be tested, a trigger molecule for inducing thrombin generation, a thrombin-specific substrate which, upon cleavage by thrombin, produces a measurable thrombin-specific signal, a trigger molecule for inducing plasmin generation, a plasmin-specific substrate which, upon cleavage by plasmin, produces a measurable plasmin-specific signal, a phospholipid-containing surface, and calcium ions. The assay allows determination of the amount of thrombin and the amount of plasmin generated in the reaction mixture in time, starting at t=0, by measuring the thrombin-specific and plasmin-specific signals.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: August 19, 2014
    Assignee: Stichting Katholieke Universiteit
    Inventor: Waander Laurens Van Heerde
  • CHEMILUMINESCENCE-BASED HAEMOSTASIS ASSAY
    Publication number: 20130337480
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Application
    Filed: December 14, 2011
    Publication date: December 19, 2013
    Applicants: CHIRALIX B.V., STICHTING KATHOLIEKE UNIVERSITEIT
    Inventors: Waander Laurens Van Heerde, Richard Hendrik Blaauw