Patents by Inventor Wade Aumiller

Wade Aumiller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ruthenium (II) catalysts for use in stereoselective cyclopropanations
    Patent number: 8558017
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran,deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 15, 2013
    Assignee: Vanda Pharmaceuticals, Inc.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • RUTHENIUM (II) CATALYSTS FOR USE IN STEREOSELECTIVE CYCLOPROPANATIONS
    Publication number: 20130023662
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Application
    Filed: December 12, 2011
    Publication date: January 24, 2013
    Applicant: VANDA PHARMECEUTICALS INC.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • RUTHENIUM (II) CATALYSTS FOR USE IN STEREOSELECTIVE CYCLOPROPANATIONS
    Publication number: 20120149906
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Application
    Filed: December 12, 2011
    Publication date: June 14, 2012
    Applicant: VANDA PHARMECEUTICALS INC.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • Ruthenium (II) catalysts for use in stereoselective cyclopropanations
    Patent number: 8097738
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: January 17, 2012
    Assignee: VANDA Pharmaceuticals Inc.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • RUTHENIUM (II) CATALYSTS FOR USE IN STEREOSELECTIVE CYCLOPROPANATIONS
    Publication number: 20100228039
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Application
    Filed: May 20, 2010
    Publication date: September 9, 2010
    Applicant: VANDA PHARMECEUTICALS INC.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • Ruthenium(II) catalysts for use in stereoselective cyclopropanations
    Patent number: 7754902
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 13, 2010
    Assignee: Vanda Pharmaceuticals, Inc.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • Ruthenium(II) catalysts for use in stereoselective cyclopropanations
    Publication number: 20070270593
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Application
    Filed: May 18, 2006
    Publication date: November 22, 2007
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger