Abstract: A surgery center includes a matrix of flow patterns and interaction nodes that are optimized by providing a physical structure that includes an admit/reception node, a pre-operative node, a surgical node, an acute recovery node and an observation node. The pre-operative node is located adjacent the admit/reception node. The surgical node is located adjacent the pre-operative node. The acute recovery node is located adjacent to the surgical node and between the surgical node and the observation node. The patient flow throughout each of the nodes is unidirectional. An instrument flow is circular and confined to the surgical node, a staff/physician flow includes a separate entry to the surgery center separate from the admit/reception node and the observation node, a supply flow is linear, and an environmental waste flow includes transitioning between a sterile zone and a non-sterile zone.