Patents by Inventor Wade Nichols RICHARDSON

Wade Nichols RICHARDSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neoepitope Vaccine Delivery Vehicle and Methods of Making the Same
    Publication number: 20230172852
    Abstract: Disclosed herein are mannan nanogels as a novel vaccine delivery platform as well as a novel method of making a self-assembling mannan nanogel for in vivo delivery of therapeutic agents.
    Type: Application
    Filed: December 6, 2022
    Publication date: June 8, 2023
    Inventors: Philip T. Liu, Clifford Anders Olson, Wade Nichols Richardson, Wendy Higashide
  • Methods of transfection for large cargo using poly(beta-amino esters)
    Patent number: 11554173
    Abstract: Methods are provided for transfecting cells with large cargo using a poly(beta-amino ester) (PBAE) molecule, and achieving high efficiency and viability. A method is provided of transfecting cells with a cargo, by forming a complex of the cargo with a (PBAE) molecule, mixing the complex with a first buffer and contacting the complex with the cells, wherein the cargo has a dimension of at least 0.1 ?m. The PBAE molecule may be formed by reacting an amine with a di(acrylate ester). In some aspects, the PBAE molecule is poly(1,4-butanediol diacrylate-co-4-amino-1-butanol). In some aspects, the PBAE molecule is capped with 1-(3-aminopropyl)-4-methylpiperazine.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: January 17, 2023
    Assignee: NANOCAV, LLC
    Inventors: Ting-Hsiang Sherry Wu, Wade Nichols Richardson
  • Methods Of Transfection For Large Cargo Using Poly(Beta-Amino Esters)
    Publication number: 20200009259
    Abstract: Methods are provided for transfecting cells with large cargo using a poly(beta-amino ester) (PBAE) molecule, and achieving high efficiency and viability. A method is provided of transfecting cells with a cargo, by forming a complex of the cargo with a (PBAE) molecule, mixing the complex with a first buffer and contacting the complex with the cells, wherein the cargo has a dimension of at least 0.1 ?m. The PBAE molecule may be formed by reacting an amine with a di(acrylate ester). In some aspects, the PBAE molecule is poly(1,4-butanediol diacrylate-co-4-amino-1-butanol). In some aspects, the PBAE molecule is capped with 1-(3-aminopropyl)-4-methylpiperazine.
    Type: Application
    Filed: July 9, 2019
    Publication date: January 9, 2020
    Inventors: Ting-Hsiang Sherry WU, Wade Nichols RICHARDSON