Patents by Inventor Wade P. Leveille
Wade P. Leveille has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11125729Abstract: In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.Type: GrantFiled: December 18, 2018Date of Patent: September 21, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille
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Patent number: 11085905Abstract: Various embodiments are generally directed to techniques for monitoring chromatographic fluid flows, such as the flow to and/or from one or more reservoirs used in chromatographic operations, for instance. In many embodiments, the chromatographic operations may include one or more of High Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), Ultra Performance Convergence Chromatography (UPC2), and the like. Several embodiments are particularly directed to a chromatographic fluid flow device (CFFD) for monitoring a change in density of a chromatographic fluid in a tube, such as by detecting the presence or absence of gas in the tube with an ultrasonic bubble detector. In various embodiments, the chromatographic fluid may include a solvent, a sample, or waste associated with a chromatographic operation.Type: GrantFiled: June 12, 2019Date of Patent: August 10, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Abhijit Tarafder, Jonathan Belanger, Moon Chul Jung, Wade P. Leveille
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Publication number: 20210229119Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.Type: ApplicationFiled: January 22, 2021Publication date: July 29, 2021Applicant: Waters Technologies CorporationInventors: Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio, Emrys Jones, Steven Derek Pringle, Stephen Hattan, Gregory T. Roman
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Publication number: 20210132012Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.Type: ApplicationFiled: October 30, 2020Publication date: May 6, 2021Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Mark J. Basile, Jeffrey Musacchio, Michael O. Fogwill, Sebastien Besner, Joseph D. Michienzi, Wade P. Leveille
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Patent number: 10953346Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.Type: GrantFiled: January 17, 2018Date of Patent: March 23, 2021Assignee: Waters Technologies CorporationInventors: Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
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Patent number: 10823713Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.Type: GrantFiled: December 19, 2017Date of Patent: November 3, 2020Assignee: Waters Technologies CorporationInventors: Wade P. Leveille, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder, Joseph Michienzi, Keith Fadgen, Kevin Wyndham, Xiangjin Song
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Patent number: 10802002Abstract: Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit. The outer tube is deformed by a first uniform radial crimp at a longitudinal location along the outer tube that surrounds the first conduit on a first side of the first joint, and a second uniform radial cramp at a longitudinal location along the outer tube that surrounds the second conduit on a second side of the first joint. The first and second uniform radial cramps form a fluid-tight seal between the first conduit and the second conduit and each have a substantially flat base region over which a diameter of the outer tube is reduced for a non-zero longitudinal length.Type: GrantFiled: May 25, 2018Date of Patent: October 13, 2020Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joseph D. Michienzi, Keith Fadgen, Wade P. Leveille, Raymond P. Fisk, Frank John Marszalkowski, Jr.
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Publication number: 20200300821Abstract: A removable seal device for fluidic coupling includes a seal body extending between a first end and a second end, the seal body including an inner channel configured to receive a flow of a fluid. The first end of the seal body includes a first sealing surface configured to create a first seal with a fitting sealing surface of a receiver fitting, and the seal body includes a second sealing surface configured to create a second seal with an end of a fluidic tube. The removable seal is configured to be removably secured to at least one of the fluidic tube, a support feature fixed to the fluidic tube, and a compression screw, such that untightening of the compression screw from the receiver fitting causes the removable seal device to be removed from the receiver fitting.Type: ApplicationFiled: March 18, 2020Publication date: September 24, 2020Inventors: Sylvain Gilles Cormier, Joseph D. Antocci, Wade P. Leveille, Sr.
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Patent number: 10753916Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.Type: GrantFiled: January 16, 2018Date of Patent: August 25, 2020Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Moon Chul Jung, Jonathan L. Belanger, Xiangjin Song, Abhijit Tarafder, Joseph A. Jarrell, Wade P. Leveille
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Patent number: 10690563Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.Type: GrantFiled: January 16, 2018Date of Patent: June 23, 2020Assignee: Waters Technologies CorporationInventors: Abhijit Tarafder, Moon Chul Jung, Jonathan L. Belanger, Xiangjin Song, Wade P. Leveille, Darryl W. Brousmiche
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Patent number: 10514117Abstract: A fitting for a fluidic coupling includes a tube assembly that includes an inner tube, an intermediate tube formed of a polymeric material and disposed over at least a portion of a length of the inner tube, and an outer tube formed of a metal and disposed over the intermediate tube. The inner tube has an inner tube endface and a first fluid channel. The intermediate tube includes an extruded portion having a length and an intermediate tube endface. The outer tube has an outer tube endface and an outer surface. First and second radial crimps are formed on the outer surface at first and second distances from the outer tube endface and extend for first and second axial lengths, respectively. The inner and outer tube endfaces are co-planar and the intermediate tube endface is separated from the inner and outer tube endfaces by the length of the extruded portion.Type: GrantFiled: September 20, 2017Date of Patent: December 24, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventor: Wade P. Leveille
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Publication number: 20190383277Abstract: Described is a multi-stage pump having at least two stages. The multi-stage pump includes a first pump stage and a second pump stage each having a chamber of different diameter and volume. The multi-stage pump also includes a plunger having first and second plunger sections. The first plunger section has a first plunger diameter, a first end configured for coupling to a drive mechanism, and a second end opposite to the first end. The second plunger section has a second plunger diameter that is less than the first plunger diameter, a third end in contact with the second end of the first plunger, and a fourth end opposite the third end. Movement of the plunger produces a displacement volume for the first chamber that is different than a displacement volume produced for the second chamber. The multi-stage pump can be configured in different operational modes to provide different flow rates.Type: ApplicationFiled: June 18, 2019Publication date: December 19, 2019Inventors: Wade P. Leveille, Jacob N. Fairchild, Jeffrey Musacchio, Joseph D. Michienzi
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Publication number: 20190376937Abstract: Various embodiments are generally directed to techniques for monitoring chromatographic fluid flows, such as the flow to and/or from one or more reservoirs used in chromatographic operations, for instance. In many embodiments, the chromatographic operations may include one or more of High Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), Ultra Performance Convergence Chromatography (UPC2), and the like. Several embodiments are particularly directed to a chromatographic fluid flow device (CFFD) for monitoring a change in density of a chromatographic fluid in a tube, such as by detecting the presence or absence of gas in the tube with an ultrasonic bubble detector. In various embodiments, the chromatographic fluid may include a solvent, a sample, or waste associated with a chromatographic operation.Type: ApplicationFiled: June 12, 2019Publication date: December 12, 2019Inventors: Abhijit Tarafder, Jonathan Belanger, Moon Chul Jung, Wade P. Leveille
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Publication number: 20190321759Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.Type: ApplicationFiled: April 5, 2019Publication date: October 24, 2019Inventors: Kevin D. Wyndham, Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille, SR.
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Publication number: 20190317062Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.Type: ApplicationFiled: April 15, 2019Publication date: October 17, 2019Inventors: Michael O. Fogwill, Curt Devlin, Theodore A. Dourdeville, Jacob N. Fairchild, Geoff C. Gerhardt, Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio
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Publication number: 20190271670Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the claim assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.Type: ApplicationFiled: May 17, 2019Publication date: September 5, 2019Inventors: Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan Hill, Raymond P. Fisk, Jonathan Belanger, Wade P. Leveille
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Patent number: 10386344Abstract: The invention relates to tubing assemblies and methods for forming a fluidic connection to make the same. The assemblies include an outer tube having disposed therein a first inner tube affixed to the outer tube, a second inner tube and a support tube disposed in the second inner tube. The second inner tube is abutted against the first inner tube. A radial crimp is made in the outer tube over the second inner tube a distance x from where the tubes abut; the distance x being such that the end of the second inner tube seals against the end of the first inner tube. Various embodiments provide assemblies suitable for use with high fluidic pressure (e.g., greater than an about 70 MPa, approximately about 10,000 psi) and formation of chromatographic column assemblies comprising a capillary tube predisposed within the first or second inner tube prior to formation of the seal.Type: GrantFiled: June 8, 2018Date of Patent: August 20, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Wade P. Leveille, Mathew H. DeLano
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Patent number: 10338038Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.Type: GrantFiled: December 10, 2012Date of Patent: July 2, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan Hill, Raymond P. Fisk, Jonathan Belanger, Wade P. Leveille
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Publication number: 20190187109Abstract: In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.Type: ApplicationFiled: December 18, 2018Publication date: June 20, 2019Inventors: Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille
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Publication number: 20180356376Abstract: The invention relates to tubing assemblies and methods for forming a fluidic connection to make the same. The assemblies include an outer tube having disposed therein a first inner tube affixed to the outer tube, a second inner tube and a support tube disposed in the second inner tube. The second inner tube is abutted against the first inner tube. A radial crimp is made in the outer tube over the second inner tube a distance x from where the tubes abut; the distance x being such that the end of the second inner tube seals against the end of the first inner tube. Various embodiments provide assemblies suitable for use with high fluidic pressure (e.g., greater than an about 70 MPa, approximately about 10,000 psi) and formation of chromatographic column assemblies comprising a capillary tube predisposed within the first or second inner tube prior to formation of the seal.Type: ApplicationFiled: June 8, 2018Publication date: December 13, 2018Inventors: Wade P. Leveille, Mathew H. DeLano