Abstract: Closed-loop deep brain stimulation using neural and behavioral biomarkers of specific motor features is provided via training a machine learning model to differentiate first neural signals generated by a biological subject that are associated with tremor in the biological subject from second neural signals generated by the biological subject that are associated with bradykinesia in the biological subject; placing a first plurality and a second plurality of deep brain stimulation electrodes in a subthalamic nucleus (STN) of the biological subject; placing a plurality of microelectrodes and a plurality of macroelectrodes in the STN; in response to identifying, by the machine learning model, a given neural signal as one of the first or second neural signals, activating a corresponding one of the first or second plurality of electrodes with a therapeutically effective voltage and current to affect deep brain stimulation in the biological subject to treat a neuromotor disorder.

Abstract: A system for placement of biocompatible electrodes in an opening formed in a patient's body part, such as DBS electrodes inserted into a patient's skull during surgical procedures in the brain. The system includes a coupled catheter and annulus. The catheter includes a guide tube having at least three cooperating guide elements configured to releasably fit together and collectively form a continuous lumen through the catheter that is dimensioned to receive an electrode therein. The annulus is configured to be placed in the opening formed in the patient's body part, and to receive the catheter therethrough. A track mechanism is used to operably couple the catheter to the annulus.

Abstract: A system for placement of biocompatible electrodes in an opening formed in a patient's body part, such as DBS electrodes inserted into a patient's skull during surgical procedures in the brain. The system includes a coupled catheter and annulus. The catheter includes a guide tube having at least three cooperating guide elements configured to releasably fit together and collectively form a continuous lumen through the catheter that is dimensioned to receive an electrode therein. The annulus is configured to be placed in the opening formed in the patient's body part, and to receive the catheter therethrough. A track mechanism is used to operably couple the catheter to the annulus.

Abstract: A peel-away electrode placement catheter includes a silicone tube, the silicone tube including perforations longitudinally positioned to spilt the silicone tube in half, a pair of separate metal semi-cylinders positioned within the silicone tube, and a deep brain stimulation (DBS) implantable electrode positioned between the pair of separate metal semi-cylinders.