Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for voice-based device operation mode management. Example methods may include determining that a device is coupled to an accessory device, and determining that being coupled to the accessory device triggers activation of a first operation mode at the device. The first operation mode presents digital content at the display in a user interface having a first content density that is less than a second content density of a second operation mode. Example methods may include causing the device to activate the first operation mode, receiving first voice data indicative of a request to change the device operation mode to the second operation mode, and causing the device to activate the second operation mode.

Abstract: The present disclosure provides an integrated platform allowing multiple users to share and exchange motion, position, image and other data of a set of replicas or phantoms mimicking genuine objects used in real life scientific laboratory within a common virtual space resembling a scientific laboratory, where the motion and position data are tracked real-time by multiple sensors embedded into the phantoms and transformed using a physically accurate rendering approach into dynamic images of their corresponding genuine objects to be displayed in an augmented reality projection, so that the users can remotely connect to the platform via a portable device to learn and practice skills of handling laboratory apparatuses from experiencing in the common virtual space with one or more of the phantoms.

Abstract: Systems and methods for variant calling in single molecule sequencing from a genomic dataset using a convolutional deep neural network. The method includes: transforming properties of each of the variants into a multi-dimensional tensor; passing the multi-dimensional tensors through a trained convolutional deep neural network to predict categorical output variables, the convolutional deep neural network minimizing a cost function iterated over each variant, the convolutional deep neural network trained using a training genomic dataset including previously identified variants, the convolutional neural network including: a plurality of pooled convolutional layers and at least two fully-connected layers connected sequentially after the last of the pooled convolutional layers, the at least two fully-connected layers comprising a second fully-connected layer connected sequentially after a first fully-connected layer; and outputting the predicted categorical output variables.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for voice-based device operation mode management. Example methods may include determining that a device is coupled to an accessory device, and determining that being coupled to the accessory device triggers activation of a first operation mode at the device. The first operation mode presents digital content at the display in a user interface having a first content density that is less than a second content density of a second operation mode. Example methods may include causing the device to activate the first operation mode, receiving first voice data indicative of a request to change the device operation mode to the second operation mode, and causing the device to activate the second operation mode.

Abstract: A method and system for predicting liver injury in vivo due to hepatocyte damage by a test compound are provided. The method includes acquiring images of fluorescently stained cells obtained from a cell culture in which the cells have been treated with a dose-range of at least the test compound and its vehicle. The cells may be hepatic cells including primary or immortalized hepatocytes, hepatoma cells or induced pluripotent stem cell-derived hepatocyte-like cells. The acquired images are segmented. The method further includes extracting and analyzing one or more phenotypic features from the segmented images, wherein the one or more phenotypic features are selected from the group of intensity, textural, morphological, or ratiometric features consisting of (a) features of DNA, (b) features of RELA (NF-KB p65), and (c) features of actin filaments at different subcellular regions and d) features of cellular organelles and their substructures in the segmented images.

Abstract: The present invention relates to a system for detecting a target enzyme in a sample, the system including a substrate, a first enzyme immobilized on the substrate via a first linker, and a second enzyme immobilized on the substrate via a second linker, wherein the first linker is cleavable by the target enzyme or the second enzyme to release the first enzyme for cleaving the second linker, thereby releasing the second enzyme; and a method for detecting a target enzyme in a sample including applying the sample to said system.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for selective requests for authentication for voice-based launching of applications. Example methods may include receiving first audio data representing an utterance, determining that the device is in a first operating mode when the audio data was received, determining that the device is in a locked state when the audio data is received, and receiving, from a remote system, a command to display information based at least on part on the audio data. Certain methods may include receiving an indication that the utterance was spoken by a user authorized to access the information while in the first operating mode and the locked state, and causing presentation of the information by the device.

Abstract: A method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample, the method including: applying the sample on an electrochemical detector having a substance selection structure, wherein the substance selection structure is sensitive to the polyamine or its derivative; applying at least one voltage bias to the electrochemical detector; and detecting a change of electrical characteristics of the electrochemical detector so as to determine the presence or the amount of the polyamine or its derivative in the sample.

Abstract: A method of determining a cell cycle stage distribution of cells includes the steps of providing a cell sample; pre-treating the cell sample with a solvent; mixing the pre-treated cell sample with a matrix solution to obtain a mixture solution; depositing the mixture solution on a sample plate; obtaining a mass spectrum analysis of the deposited mixture solution; and identifying at least two marker peaks from the mass spectrum analysis, wherein a ratio between the marker peaks provides information about a cell cycle stage distribution of the cell sample, wherein the mass spectrum analysis is a matrix-assisted laser desorption/ionization time-of-flight mass spectrum test.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for selective requests for authentication for voice-based launching of applications. Example methods may include receiving first audio data representing an utterance, determining that the device is in a first operating mode when the audio data was received, determining that the device is in a locked state when the audio data is received, and receiving, from a remote system, a command to display information based at least on part on the audio data. Certain methods may include receiving an indication that the utterance was spoken by a user authorized to access the information while in the first operating mode and the locked state, and causing presentation of the information by the device.

Abstract: In various embodiments, a pharmaceutical composition comprising an effective amount of a peptide having the amino acid sequence represented by Formula (I) or an analog thereof, and a pharmaceutically tolerable excipient is described. In some embodiments, the analog of the peptide of Formula (I), comprises the peptide sequence of Formula (I) wherein one or more of the amino acids residues are modified by a) C-terminal modification; b) D-amino acid substitution; and/or c) deletion of one or more amino acid residues. A method of inhibiting the growth of a microorganism comprising contacting the microorganism in a medium with an effective amount of the peptide of Formula (I) or an analog thereof is also described, as are similar methods of treating a disease or disorder associated with microbial activity in a subject by administering an effective amount of a peptide of Formula (I) or an analog thereof and a pharmaceutically tolerable excipient to the subject.

Abstract: A method and system for predicting liver injury in vivo due to hepatocyte damage by a test compound are provided. The method includes acquiring images of fluorescently stained cells obtained from a cell culture in which the cells have been treated with a dose-range of at least the test compound and its vehicle. The cells may be hepatic cells including primary or immortalized hepatocytes, hepatoma cells or induced pluripotent stem cell-derived hepatocyte-like cells. The acquired images are segmented. The method further includes extracting and analyzing one or more phenotypic features from the segmented images, wherein the one or more phenotypic features are selected from the group of intensity, textural, morphological, or ratiometric features consisting of (a) features of DNA, (b) features of RELA (NF-KB p65), and (c) features of actin filaments at different subcellular regions and d) features of cellular organelles and their substructures in the segmented images.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for voice-forward graphical user interface mode management. Example methods include determining that a device is coupled to an accessory device, determining that being coupled to the accessory device causes the device to deactivate a first operating mode and activate a second operating mode, where the second operating mode has a lower content density than the first operating mode, and determining that an application setting of an application executing on the device is causing the device to remain in the first operating mode. Example methods may include determining that a new value is associated with the application setting, and causing the device to activate the second operating mode.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for voice-based device operation mode management. Example methods may include determining that a device is coupled to an accessory device, and determining that being coupled to the accessory device triggers activation of a first operation mode at the device. The first operation mode presents digital content at the display in a user interface having a first content density that is less than a second content density of a second operation mode. Example methods may include causing the device to activate the first operation mode, receiving first voice data indicative of a request to change the device operation mode to the second operation mode, and causing the device to activate the second operation mode.

Abstract: A percussion mechanism device, in particular for an impact wrench, includes a drivable drive shaft that has at least one guide groove, an output shaft, and a percussion unit that includes an anvil coupled with the output shaft in a rotationally fixed manner, a hammer, and at least one ball. The hammer is supported via the at least one ball along the at least one guide groove on the drive shaft and includes an at least regionally concavely curved ball guidance area that has an axial clearance from the at least one ball at a radially innermost point that is greater than a radial clearance between the at least one ball and a radially innermost point of a concave ball guidance area of the at least one guide groove.

Abstract: Systems and methods for variant calling in single molecule sequencing from a genomic dataset using a convolutional deep neural network. The method includes: transforming properties of each of the variants into a multi-dimensional tensor; passing the multi-dimensional tensors through a trained convolutional deep neural network to predict categorical output variables, the convolutional deep neural network minimizing a cost function iterated over each variant, the convolutional deep neural network trained using a training genomic dataset including previously identified variants, the convolutional neural network including: a plurality of pooled convolutional layers and at least two fully-connected layers connected sequentially after the last of the pooled convolutional layers, the at least two fully-connected layers comprising a second fully-connected layer connected sequentially after a first fully-connected layer; and outputting the predicted categorical output variables.

Abstract: A method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample, the method including: applying the sample on an electrochemical detector having a substance selection structure, wherein the substance selection structure is sensitive to the polyamine or its derivative; applying at least one voltage bias to the electrochemical detector; and detecting a change of electrical characteristics of the electrochemical detector so as to determine the presence or the amount of the polyamine or its derivative in the sample.

Abstract: A pharmaceutical composition includes an effective amount of a peptide or an analog thereof, and a pharmaceutically tolerable excipient, wherein the peptide includes the amino acid sequence of SEQ ID NO. 17. An analog of a peptide including the amino acid sequence of SEQ ID NO. 17, wherein one or more amino acids residues are modified by a) C-terminal modification; b) D-amino acid substitution; and/or c) deletion of one or more amino acid residues. A method of inhibiting the growth of a microorganism includes contacting the microorganism in a medium with an effective amount of a peptide or an analog thereof, wherein the peptide includes the amino acid sequence of SEQ ID NO. 17. A method of treating a disease or disorder associated with microbial activity in a subject includes administering an effective amount of a peptide or an analog thereof to the subject, the peptide including the amino acid sequence of SEQ ID NO. 17.

Abstract: A dock device connects participating devices such as a tablet device and an audio activated device, allowing them to operate as a single device. These participating devices may be associated with different accounts, each account being associated with particular “speechlets” or data processing functions. A natural language understanding (NLU) system uses NLU models to process text obtained from an automatic speech recognition (ASR) system to determine a set of possible intents. A second set of possible intents may then be generated that is limited to those possible intents that correspond to the speechlets associated with the docked device. The intents within the second set of possible intents are ranked, and the highest ranked intent may be deemed to be the intent of the user. Command data corresponding to the highest ranked intent may be generated and used to perform the action associated with that intent.

Abstract: A chemosensing hydrogel is provided that undergoes a colorimetric reaction in response to the detection of a biogenic amine vapor, such as a biogenic amine vapor that is a by-product resulting from food spoilage. In an embodiment, an apparatus for detection of biogenic amines, is provided that includes a hydrogel having a bimetallic iron(II)-iron(III) complex disposed within the hydrogel, wherein the hydrogel is configured to change from a first color to a second color in response to exposure to a biogenic amine.