Abstract: The techniques described herein relate to systems and methods for diagnosing diseases in animal patients. In some cases, a method includes providing a set of global data to a global data center and processing the set of global data and categorizing it into data clusters, where each data cluster corresponds to a diagnostic indicator for assessment of a physiological or pathological condition. The method can further include measuring data of a local patient using measurement equipment of a local autonomous cell and communicating the local measurement data from the local autonomous cell to the global data center. The local measurement data can be processed, and the processed local measurement data can be compared with the data clusters to determine a local diagnostic indicator for the local patient. The local diagnostic indicator can then be communicated from the global data center to the local autonomous cell.

Abstract: In some implementations, a computing system can deliver personalized content while preserving user privacy. For example, the computing system can include a content server that filters, deduplicates, and generates clusters of content items (e.g., articles, news stories, etc.) that are relevant to an investment identifier received in a request from a client device. The content server can send the clusters of content items to the requesting client. Upon receiving the clusters of content items, requesting client device can evaluate the content items based on user preferences stored on the user device and select a representative content item from one or more content item clusters. The selected content item can then be presented on a display of the user device. Thus, personalization of content item selection and presentation can be performed without distributing user preference data outside of the user device thereby preserving user privacy.

Abstract: An object of the present invention is to provide a method for obtaining cells having a high migration ability or cells having a high proliferation ability as cells having an increased therapeutic effect on diseases. The present invention is a method for preparing cells for treating diseases, a method for promoting a migration ability of cells, and a method for promoting a proliferative ability of cells, each of the methods comprising subjecting cells to ultrasonic treatment. The frequency of the ultrasonic treatment is preferably 30 kilohertz to 2.0 megahertz, and the cells are preferably mesenchymal stem cells. In addition, the present invention also includes cells obtained by the preparation method of the present invention.

Abstract: The techniques described herein relate to a method for diagnosing diseases in human patients including providing a set of global electrocardiograms to a global data center, processing the set of global electrocardiograms, and categorizing the processed set of global electrocardiograms into data clusters. Each data cluster can correspond to a diagnostic indicator for assessment of a physiological or pathological condition. The method can further include measuring a local electrocardiogram of a local patient using an electrocardiograph machine of a local autonomous cell, communicating the local electrocardiogram and local patient data from the local autonomous cell to the global data center, processing the local electrocardiogram, and comparing the processed local electrocardiogram with the data clusters to determine a local diagnostic indicator for the local patient. The local diagnostic indicator can also be communicated from the global data center to the local autonomous cell.

Abstract: The techniques described herein relate to systems and methods for diagnosing diseases in human patients. In some cases, a method includes providing a set of global data to a global data center and processing the set of global data and categorizing it into data clusters, where each data cluster corresponds to a diagnostic indicator for assessment of a physiological or pathological condition. The method can further include measuring data of a local patient using measurement equipment of a local autonomous cell and communicating the local measurement data from the local autonomous cell to the global data center. The local measurement data can be processed, and the processed local measurement data can be compared with the data clusters to determine a local diagnostic indicator for the local patient. The local diagnostic indicator can then be communicated from the global data center to the local autonomous cell.

Abstract: Provided herein are bilobalide derivative compounds, processes for making, methods of using, and uses thereof for preventing or treating neurological disease and cancer.

Abstract: Techniques for controlling remote antenna systems. An example method of receiving radio frequency signals with a remote antenna module includes providing a first signal to a remote receiver on a conductor, receiving a control signal from the remote receiver on the conductor, wherein the control signal is a bias voltage on the conductor, and providing a second signal on the conductor in response to receiving the control signal.

Abstract: The present disclosure provides improved compositions for adoptive T cell therapies targeting CD33 for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith. The present disclosure also relates to adoptive T cell therapies targeting CD33 and another target antigen for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

Abstract: A method for analyzing environmental sounds to identify repeating noises due to power equipment for purposes of controlling noise pollution is disclosed. Ambient sounds are sampled with microphones and the resulting data analyzed by an edge computing device. The samples are compared to stored data with a convolutional neural network by the edge computing device which also performs pitch shifting and cycle shifting to reduce false negatives. Positive results are reported via LoRa and/or 4G to a cloud platform and/or backend server.

Abstract: Cell-free DNA molecules in a mixture of a biological sample can be analyzed to detect viral DNA. Methylation of viral DNA molecules at one or more sites in the viral genome can be determined. Mixture methylation level(s) can be measured based on one or more amounts of the plurality of cell-free DNA molecules methylated at a set of site(s) of the particular viral genome. The mixture methylation level(s) can be determined in various ways, e.g., as a density of cell-free DNA molecules that are methylated at a site or across multiple sites or regions. The mixture methylation level(s) can be compared to reference methylation level(s), e.g., determined from at least two cohorts of other subjects. The cohorts can have different classifications (including the first condition) associated with the particular viral genome. A first classification of whether the subject has the first condition can be determined based on the comparing.

Abstract: The present invention relates to a physiologically relevant, high-throughput in vitro human lung injury model used for studying therapeutic interventions against severe respiratory pathogens. In this model, human alveolar epithelial cells are infected with the highly pathogenic influenza A virus A/HK/483/97 (H5N1) and subsequently treated with extracellular vesicles (EVs) 24 hours post-infection. Influenza A(H5N1) infection significantly reduces alveolar fluid clearance (AFC) and increases alveolar permeability (APP) after 24 hours. The administration of therapeutic EVs restores both AFC and APP in vitro, reduces the expression of dysregulated proinflammatory cytokines, and enhances virus-suppressed alveolar sodium and chloride transporters in the infected epithelial cells.

Abstract: This invention describes a novel blockchain network system and method tailored for managing the time and logic sensitive scheduling operations, specifically allowing the scheduling of executions in the future. The novel blockchain network system and scheduling method is a Layer-1 solution that preserves the open, distributed, decentralised, verifiable, robust, immutable and secure data archiving properties of blockchain network and is distinguished from other Layer-2 protocols built on top of Layer-1 blockchain networks. With schedule messages, self-invoking contracts can be realised to carry out recurring tasks, updates, or transactions without external activation or approval.

Abstract: A visual indication device includes: device body provided with a concave portion with a surface opening; semi-transparent reflective mirror positioned to cover the surface opening of the concave portion; reflective mirror arranged on a bottom surface of the concave portion; light source located inside the device body and configured to generate light; light guide element arranged on one side of the concave portion to guide the light to refract towards the semi-transparent reflective mirror. There is a distance space between the semi-transparent mirror and the reflective mirror that can duplicate the light to be a 3D pattern from the light guide. The light effect is generated by a few light sources—LED, which can form many moving patterns by dimming and growing light. That can provide more indication messages and the look decoration to users.

Abstract: A coding method for data communication is provided, and may be applied to a plurality of scenarios such as a metro network, a backbone network, and a data center interconnection. The method includes: forming a first codeword, where the first codeword includes n image bits and n to-be-transmitted bits, the n image bits are selected from to-be-transmitted bits in m source codewords, the source codeword is a codeword formed before the first codeword, both n and m are positive integers, and n>m; and sending the n to-be-transmitted bits in the first codeword. The bit in the first codeword is protected by a plurality of codewords generated at different moments, and a coding gain effect is better. In addition, the bit in the codeword is protected by different quantities of codewords.

Abstract: The present invention provides a co-culture system of human alveolar epithelial and endothelial cells to study the interactions within the epithelial-endothelial barrier in the lungs. It demonstrates that infection with highly pathogenic influenza A virus A/HK/483/97 (H5N1) significantly decreases alveolar fluid clearance (AFC) and increases protein permeability (APP). The administration of therapeutic extracellular vesicles (EVs) after infection effectively restores AFC and APP, reduces viral replication, and enhances the expression of anti-viral genes. This invention highlights the therapeutic potential of EVs and offers a valuable tool for investigating acute lung injury and improving lung drug delivery techniques.

Abstract: The present disclosure relates to polymer resins, fibers, and yarns with permanent antimicrobial activity, and a method of producing the same. In one embodiment, the antimicrobial polymer resin comprises a polymer having less than 2500 ppm of zinc dispersed within the polymer, less than 1000 ppm of phosphorus, wherein the weight ratio of zinc to phosphorus is at least 1.3:1 or less than 0.64:1.

Abstract: A circuit for determining head gimbal assembly (HGA) height is provided. The circuit includes a first switch configured to be controlled by a first clock signal, an amplifier, and a first capacitor coupled to the first switch, wherein the first capacitor is formed by at least part of a head gimbal assembly and a storage media. The circuit further includes a second capacitor coupled to an input of the amplifier, and an output of the amplifier, wherein the second capacitor is configured to store a charge from the first capacitor over one or more cycles of the first clock signal. The amplifier is configured to generate an output voltage based, at least in part, on a change in the capacitance of the first capacitor over the one or more cycles of the first clock signal.

Abstract: Techniques are described to continuously calculate an inverter DC power of a synchronous machine, e.g., motor or generator, based on the individual phase currents, DC link voltage, and gate signals, which can be compared against the commanded mechanical power based of the estimated rotor speed and commanded torque. A controller can determine whether to shut down the inverter, such as the pulse width modulation (PWM), if the DC power is greater than a threshold value. Such a threshold can be defined to allow an acceptable position and speed estimation error margin.

Abstract: The present disclosure relates to pharmaceutical compounds of the Formula (I), (Ia), (Ib), or (Ic) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (Ia), (Ib), or (Ic). Such methods of use include treatment of ciliopathies.