Patents by Inventor Wai-Pan Chan

Wai-Pan Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated multimodal sensor device for intracranial neuromonitoring
    Patent number: 10463304
    Abstract: There is provided a monolithically integrated multimodal sensor device for intracranial neuromonitoring, the sensor device including: a single substrate; a temperature sensor formed on a first portion of the single substrate for detecting temperature; a pressure sensor formed on a second portion of the single substrate for detecting intracranial pressure; and an oxygen sensor formed on a third portion of the single substrate for detecting oxygen concentration. In particular, sensing portions of the temperature sensor, the oxygen sensor and the pressure sensor, respectively, are formed at different layers of the sensor device. There is also provided an integrated multimodal sensor system incorporating the sensor device and the associated methods of fabrication.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: November 5, 2019
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, SINGAPORE HEALTH SERVICES PTE. LTD.
    Inventors: Wai Pan Chan, Margarita Sofia Narducci, Yuan Gao, Julius Ming Lin Tsai, Ruiqi Lim, Ming-Yuan Cheng, Abdur Rub Abdur Rahman, Mi Kyoung Park, Minkyu Je, Jai Prashanth Rao
  • INTEGRATED MULTIMODAL SENSOR DEVICE FOR INTRACRANIAL NEUROMONITORING
    Publication number: 20160135749
    Abstract: There is provided a monolithically integrated multimodal sensor device for intracranial neuromonitoring, the sensor device including: a single substrate; a temperature sensor formed on a first portion of the single substrate for detecting temperature; a pressure sensor formed on a second portion of the single substrate for detecting intracranial pressure; and an oxygen sensor formed on a third portion of the single substrate for detecting oxygen concentration. In particular, sensing portions of the temperature sensor, the oxygen sensor and the pressure sensor, respectively, are formed at different layers of the sensor device. There is also provided an integrated multimodal sensor system incorporating the sensor device and the associated methods of fabrication.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 19, 2016
    Inventors: Wai Pan CHAN, Margarita Sofia MARDUCCI, Yuan GAO, Julius Ming Lin TSAI, Ruiqi LIM, Ming-Yuan CHENG, Abdur Rub Abdur RAHMAN, Mi Kyoung PARK, Minkyu JE, Jai Prashanth RAO
  • Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20080260715
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: May 18, 2007
    Publication date: October 23, 2008
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Swiedler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Methods for producing and purifying recombinant alpha-L-iduronidase
    Publication number: 20060040348
    Abstract: The present invention provides a recombinant human ?-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human ?-L-iduronidase enzyme thereof.
    Type: Application
    Filed: November 24, 2003
    Publication date: February 23, 2006
    Inventors: Minmin Qin, Wai-Pan Chan, Lin Chen, Paul Fitzpatrick, John Henstrand, Dan Wendt, Gary Zecherle, Christopher Starr, Emil Kakkis
  • Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20050287133
    Abstract: The present invention provides a highly purified recombinant, human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 29, 2005
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Minmin Qin, Gary Zecherle, Wai-Pan Chan, Paul Fitzpatrick, Stuart Swiedler, John Henstrand, Dan Wendt, Lin Chen, Christopher Starr
  • Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Patent number: 6972124
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: December 6, 2005
    Assignee: BioMarin Pharmaceuticals Inc.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Sweidler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Patent number: 6866844
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: March 15, 2005
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Minmin Qin, John M. Henstrand, Gary N. Zecherle, Dan J. Wendt, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, Christopher M. Starr
  • Precursor of N-acetylgalactosamine-4-sufatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20040131605
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: November 7, 2003
    Publication date: July 8, 2004
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Sweidler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20040101524
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: November 7, 2002
    Publication date: May 27, 2004
    Inventors: Minmin Qin, John M. Henstrand, Gary N. Zecherle, Dan J. Wendt, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, Christopher M. Starr
  • Recombinant &agr;-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
    Patent number: 6569661
    Abstract: The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme as well as methods to treat certain genetic disorders including &agr;-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 27, 2003
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Minmin Qin, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, John M. Hendstrand, Dan J. Wendt, Gary N. Zecherle, Christopher M. Starr, Emil D. Kakkis
  • Methods for producing and purifying recombinant alpha-L-iduronidase
    Publication number: 20020146802
    Abstract: The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme thereof.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 10, 2002
    Inventors: Minmin Qin, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, John M. Henstrand, Dan J. Wendt, Gary N. Zecherle, Christopher M. Starr, Emil D. Kakkis