Abstract: Disclosed herein are systems and methods for predicting risk of late age-related macular degeneration (AMD). The method may include receiving one or more color fundus photograph (CFP) images from both eyes of a patient, classifying each CFP image, and predicting the risk of late AMD by estimating a time to late AMD. Classifying each CFP image may include extract one or more deep features for macular drusen and pigmentary abnormalities in each CFP image, grading the drusen and pigmentary abnormalities and/or detecting the presence of RPD in each CFP image. Predicting the risk of late AMD may include estimating a time to late AMD using a Cox proportional hazard model using the presence of RPD, the one or more deep features, and/or the graded drusen and pigmentary abnormalities.

Abstract: Methods are disclosed for treating and/or preventing retinal degeneration is a subject. In some embodiments, the method includes administering to the subject a therapeutically effective amount of a selective estrogen receptor modulator (SERM) to treat the retinal degeneration in the subject. In other embodiments, the SERM is administered orally. In some examples, the SERM is tamoxifen, afimoxifene, raloxifene, bazedoxifene, arzoxifene, desmethylarzoxifene, or a salt or derivative thereof, or combinations thereof.

Abstract: Methods are disclosed for treating and/or preventing retinal degeneration is a subject. In some embodiments, the method includes administering to the subject a therapeutically effective amount of a selective estrogen receptor modulator (SERM) to treat the retinal degeneration in the subject. In other embodiments, the SERM is administered orally. In some examples, the SERM is tamoxifen, afimoxifene, raloxifene, bazedoxifene, arzoxifene, desmethylarzoxifene, or a salt or derivative thereof, or combinations thereof.

Abstract: A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is then propelled toward the cell resulting in the particle contacting the cell for a time sufficient for the dye or nucleic acid to leave the particle and enter the cell. The present method allows for the differential labeling of individual cells within dense populations of cells.

Abstract: A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is then propelled toward the cell resulting in the particle contacting the cell for a time sufficient for the dye or nucleic acid to leave the particle and enter the cell. The present method allows for the differential labeling of individual cells within dense populations of cells.

Abstract: A disposable diaper is provided with a pair of side flaps lying transversely outside the associated side edge of an absorbent core, and the side flaps is formed by a first side sheet connected to the associated side edge portion of a topsheet lying in the vicinity of the associated side edge of the core and extending longitudinally of the diaper and a second side sheet connected to the associated side edge portion of the topsheet and the associated side edge portion of a backsheet both lying in the vicinity of the associated side edge of the core wherein both the first and second side sheets have a water pressure resistance of 100˜1500 mm and a breathing resistance of 0.03˜0.8 Kpa·s/m.