Abstract: Disclosed herein are methods for delivering a drug to the brain of a subject and monitoring the distribution of the drug therein. The method includes steps of: (a) intranasally administering of a first and second liposomes respectively loaded with the drug and a computed tomography (CT) contrast agent therein to the subject; (b) subjecting the brain of the subject of step (a) to a magnetic resonance imaging (MRI) scan; and (c) measuring chemical exchange saturation transfer (CEST) signals during the MRI scan in both olfactory bulb (OB) and frontal lobe (FL) regions at 1.2 ppm, 4.3 ppm, and ?3.4 ppm, respectively.

Abstract: A tricuspid valve apparatus may include a frame and an associated neo-prosthetic valve. The frame acts as a stabilizing structure that extends cephalad into the morphologic or functional right atrium (upstream) and caudally into the morphologic or functional right ventricle (downstream). The frame comprises a strutted atrial dome that conforms to the atrium without obstruction of blood flow from the incoming great veins (i.e. superior vena cava and inferior vena cava) or other anomalous veins and/or tributaries. The frame further comprises ventricular struts to be placed within the right ventricle to secure the neo-prosthetic valve in a desired position. The assembly of the frame and valve is collapsible so that prior to deployment the assembly is placed in a vascular catheter, and then self-expands upon release in the heart.

Abstract: An encoding method, a decoding method, and an optical module are described relating to data transmission technologies. The method, carried out by an optical module includes obtaining an optical transmission mode used for signal transmission. The method further includes receiving a signal on which outer-code encoding has been performed. The optical module determines, based on the optical transmission mode, an inner-code encoding scheme to be used by the optical module to perform inner-code encoding on the signal on which outer-code encoding has been performed. The method further includes performing, by using the inner-code encoding scheme, inner-code encoding on the signal on which outer-code encoding has been performed. The optical module outputs a signal on which inner-code encoding has been performed. As a result, error correction performance of the Ethernet may be improved.

Abstract: Systems, methods, and apparatuses are provided for diagnosing auto-immune diseases such as systemic lupus erythematosus (SLE) based on the sizes, methylation levels, and/or genomic characteristics of circulating DNA molecules. Patients provide blood or other tissue samples containing cell-free nucleic molecules for analysis. Massively parallel and/or methylation-aware sequencing can be used to determine the sizes and methylation levels of individual DNA molecules and identify the number of molecules originating from different genomic regions.

Abstract: An antenna array with a layered structure having a base layer with a metamaterial structure, a printed circuit board (PCB) layers, a feed layer arranged on the opposite side of the PCB from the RF IC(s), and a radiating layer arranged on the feed layer. The radiating layer having a plurality of radiating elements. The metamaterial structure is arranged to attenuate electromagnetic radiation propagating between the at least two adjacent waveguides in the frequency band.

Abstract: Any primitive cells or blocks can be represented physically by a Barycenter compact model (or Barycenter model), and any black box model can also be physically represented by a Barycenter compact model physically. A boundary condition between blocks is formulated by the Barycenter compact model. Boundary condition problems between blocks can be limited within two levels only if using the Barycenter compact model.

Abstract: The disclosed technologies provide functionality for collecting quality of service (“QoS”) statistics for in-use child physical functions of multiple physical function (“PF”) non-volatile memory devices (“MFNDs”). A host computing device creates a child PF on a MFND and configures the child PF on the MFND to provide a specified QoS level to an associated VM executing on the host computing device. The MFND then collects child PF QoS statistics for the child PF that describe the utilization of resources provided by child PF to an assigned VM. The MFND provides the child PF QoS statistics from the MFND to the host computing device. The collected child PF QoS statistics can be utilized to inform decisions regarding reallocation of MFND-provided resources, provisioning of new MFND-provided resources, and for other purposes.

Abstract: A wheel brake is disclosed to communicate with at least one wheel of a wheeled article (e.g., a wagon) to prevent the wheel from rotating and the wheeled article from rolling away. A toothed locking gear is attached to a hub of the wheel so that the wheel and the locking gear rotate together. A brake pedal of the wheel brake is pivotally connected to the wagon at a wheel bracket thereof to be rotatable in response to a pushing force applied thereto towards and into locking engagement with the locking gear. A coupler (e.g., a locking pin) of the brake pedal is received between a successive pair of teeth of the toothed locking gear, such that the locking gear and the wheel to which the locking gear is attached are unable to rotate, whereby the wheeled article is held in place.

Abstract: A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.

Abstract: Any primitive cells or blocks can be represented physically by a Barycenter compact model (or Barycenter model), and any black box model can also be physically represented by a Barycenter compact model physically. A boundary condition between blocks is formulated by the Barycenter compact model. Boundary condition problems between blocks can be limited within two levels only if using the Barycenter compact model.

Abstract: A light filter (100) includes at least one layer of binder matrix (110) and a multitude of transparent crystals (120). The multitude of transparent crystals (120) are irregularly and laterally dispersed in the at least one layer of binder matrix (110), such that light passing through the light filter (100) is separated into different wavelengths and polarized into different orientations.

Abstract: Methods, apparatus, systems, and articles of manufacture to manage application access in networked environments are disclosed. An example method includes monitoring accesses made using a credential to a first set of one or more application programming interfaces (APIs) and with a second set of one or more APIs, the credential associated with a first permission for access to the first set of one or more APIs and a second permission for access to the second set of one or more APIs, determining, based on access to one or more APIs of the first set of one or more APIs using the credential, that the first permission is to be suspended, and in response to the determination that the first permission is to be suspended, suspending the first permission while maintaining the second permission.

Abstract: The present disclosure relates to tissue traction devices and systems. In one example, a tissue tensioning system may include a filament having a first end comprising an attachment member, a second end, and a length therebetween extendable externally along a catheter. A first tissue fastener may be engageable with the attachment member and with a target tissue. The second end of the filament may be translatable to adjust a tensional force along the filament.

Abstract: Disclosed is a wagon adapted to be folded between an expanded open configuration and a compact collapsed configuration. A basket of the wagon is carried by a collapsible frame having height adjustment legs at the corners thereof. Height adjustment guides that stand upwardly from wheel brackets are slidable up and down through respective height adjustment legs such that the elevation of the frame and the basket carried thereby can be selectively changed. Rotatable handles are pivotally attached to the wagon at the front and the rear of the wagon frame. Telescoping canopy support assemblies are removably received downwardly within and upwardly from respective ones of the height adjustment guides to hold a removable canopy over the wagon basket. A collapsible wagon frame support has a set of rotatable frame reinforcing rods pivotally and detachably connected by ball and socket couplings to the bottom of the wagon frame at the corners thereof.

Abstract: The subject invention pertains to a novel system capable of long-term monitoring the concentration of a typical analyte in body fluid. The invention includes an untethered battery-free concentration monitor and an external data recorder to continuously measure the concentration of certain analytes and send out signals corresponding to the measured analytes concentration in real-time.

Abstract: The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.

Abstract: An integrated robotic system and methods for delivery and on-demand tasks of magnetic devices in a body for different clinical applications are provided. The integrated robotic system includes a magnetic actuation device, a plurality of imaging devices, a delivery device, and at least one magnetic device. The magnetic actuation device includes a permanent magnet or an electromagnetic coil system, and a controller for controlling the magnetic device. The plurality of imaging devices include two or more imaging modalities for capturing images of the magnetic device and tracking locations of the magnetic device in the body. The magnetic device includes one or more selected from a millimeter-sized robot, a microrobot, a nanorobot, a microrobotic swarm, and particles or drugs that respond to a magnetic field and small enough to be delivered by the delivery device.

Abstract: The present invention provides a method for predicting a cancer patient's responsiveness to anti-EGFR cancer drugs such as erlotinib based on the presence of one or more mutations in the MAPK1 genomic sequence. Related kits and therapeutic methods are also provided.