Patents by Inventor Wai-Yee Leung

Wai-Yee Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080145526
    Abstract: Luminescent metal complexes, methods of producing and/or designing same, methods of using same, and associated technology, are disclosed herein. A luminescent metal complex may be useful for a variety of applications, such as staining, detection, and/or identification, for example, of substances, such as poly(amino acids), for example. Further by way of example, a luminescent metal complex may be useful for staining, detecting, and/or identifying poly(amino acids) that are associated with any of various environments, such as a gel or a gel matrix, such as any associated with SDS-PAGE, for example, a surface environment, such as any associated with western blot, for example, and/or the like. Compositions, solutions, and kits comprising a luminescent metal complex are also disclosed herein.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 19, 2008
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Jie Yang
  • Publication number: 20080113341
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: January 16, 2008
    Publication date: May 15, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG
  • Publication number: 20080032379
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Application
    Filed: October 12, 2007
    Publication date: February 7, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Richard Haugland, Wai-Yee Leung
  • Publication number: 20070232805
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: February 14, 2007
    Publication date: October 4, 2007
    Applicant: INVITROGEN CORPORATION
    Inventors: Wai-Yee LEUNG, Ching-Ying CHEUNG, Stephen YUE
  • Publication number: 20070178512
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: February 14, 2007
    Publication date: August 2, 2007
    Applicant: INVITROGEN CORPORATION
    Inventors: Wai-Yee LEUNG, Ching-Ying CHEUNG, Stephen YUE
  • Publication number: 20070178511
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: February 14, 2007
    Publication date: August 2, 2007
    Applicant: INVITROGEN CORPORATION
    Inventors: Wai-Yee LEUNG, Ching-Ying CHEUNG, Stephen YUE
  • Publication number: 20060211028
    Abstract: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.
    Type: Application
    Filed: March 16, 2006
    Publication date: September 21, 2006
    Inventors: Fei Mao, Wai-Yee Leung, Xing Xin
  • Publication number: 20060211029
    Abstract: Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.
    Type: Application
    Filed: March 16, 2006
    Publication date: September 21, 2006
    Inventors: Fei Mao, Wai-Yee Leung
  • Publication number: 20060099638
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: December 20, 2005
    Publication date: May 11, 2006
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Publication number: 20060057670
    Abstract: The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).
    Type: Application
    Filed: September 10, 2004
    Publication date: March 16, 2006
    Applicants: The Chinese University of Hong Kong, The Hospital Authority
    Inventors: Jao Yiu Sung, Lik Chan, Kwok Wing Tsui, Kwong Leung, Shu Kam Mok, Angeline Bartholomeusz, Wai Yee Leung, Kin Lee
  • Publication number: 20060057601
    Abstract: The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).
    Type: Application
    Filed: December 20, 2004
    Publication date: March 16, 2006
    Applicants: The Chinese University of Hong Kong, Hospital Authority
    Inventors: Jao Yiu Sung, Lik Chan, Kwok Wing Tsui, Kwong Leung, Shu Kam Mok, Angeline Bartholomeusz, Wai Yee Leung, Kin Lee
  • Publication number: 20060004188
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: June 10, 2005
    Publication date: January 5, 2006
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Patent number: 6977305
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: September 29, 2001
    Date of Patent: December 20, 2005
    Assignee: Molecular Probes, Inc.
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Patent number: 6974873
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: December 13, 2005
    Assignee: Molecular Probes, Inc.
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Publication number: 20050233307
    Abstract: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6.
    Type: Application
    Filed: September 12, 2003
    Publication date: October 20, 2005
    Inventors: Kyle Gee, Courtenay Hart, Wai-Yee Leung, Wayne Patton, Aleksey Rukavishnikov, Richard Haugland, Zhenjun Diwu
  • Publication number: 20050214807
    Abstract: The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
    Type: Application
    Filed: November 19, 2004
    Publication date: September 29, 2005
    Inventors: Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch
  • Publication number: 20050123935
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 9, 2005
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • Publication number: 20050096315
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: November 1, 2004
    Publication date: May 5, 2005
    Inventors: Robert Batchelor, Yue Ge, Kyle Gee, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg
  • Publication number: 20020077487
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: September 29, 2001
    Publication date: June 20, 2002
    Applicant: MOLECULAR PROBES, INC.
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Publication number: 20020064794
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: October 1, 2001
    Publication date: May 30, 2002
    Applicant: MOLECULAR PROBES, INC.
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue