Abstract: A circuit that protects against electrostatic discharge and electrical over stress is provided. The circuit includes a first transistor including a substrate. An internal predetermined voltage source biases the substrate of the first transistor. The internal predetermined voltage source is greater than or equal to a source voltage provided to a source of the first transistor and isolates a substrate voltage of the first transistor from a supply voltage of the circuit. A first resistor is coupled to a gate of the first transistor and ground. The circuit also includes a zener diode coupled between ground and the supply voltage of the circuit. The zener diode shorts to ground if the supply voltage of the circuit exceeds the breakdown voltage of the zener diode.