Patent number: 6747154
Abstract: A process for preparing a compound of formula 1
from a compound of formula 2
the process comprising reacting in one step the compound of formula 2 with a compound of formula 3
wherein:
X− is chlorine, bromine, iodine, methanesulfonate, or trifluoromethanesulfonate;
R1 is hydroxy, C1-C4-alkyl, C1-C4-alkoxy, CF3, or fluorine;
Ar is phenyl, naphthyl, thienyl, and furyl, each optionally mono- or disubstituted with one or two groups selected from C1-C4-alkyl, C1-C4-alkoxy, hydroxy, fluorine, chlorine, bromine, or CF3;
Y− is chlorine, bromine, iodine, methanesulfonate, or trifluoromethanesulfonate; and
R is hydroxy, methoxy, ethoxy, O—N-succinimide, O—N-phthalimide, phenyloxy, nitrophenyloxy, fluorophenyloxy, pentafluorophenyloxy, vinyloxy, 2-allyloxy, —S-methyl, —S-ethyl, or —S-phenyl.
Type:
Grant
Filed:
January 9, 2003
Date of Patent:
June 8, 2004
Assignee:
Boehringer Ingelheim Pharma GmbH & Co. KG
Inventors:
Joerg Brandenburg, Waldemar Franz-Augustin Pfrengle, Werner Rall